Basic/Clinical Science Session
Metabolic Communication and the Kidney Proximal Tubule
October 26, 2024 | 10:30 AM - 12:30 PM
Location: Room 6D/E, Convention Center
Session Description
The proximal tubule controls kidney metabolism and affects cardiovascular and kidney health. Stress-induced metabolic rewiring of the proximal tubule is connected to its physiology, but establishing mechanistic connections demands novel approaches. This session explores how the proximal tubule senses, integrates, and acts on metabolic cues; presents examples of metabolic communication; discusses how kidney proximal tubule metabolic rewiring affects function; and explores how measuring proximal tubule metabolite secretion can be applied in clinical practice.
Learning Objective(s)
- Explain the role of metabolite reabsorption, secretion, and intermediate metabolism in propagating kidney diseases
- Describe how remote sensing can influence proximal tubule function and metabolism
- Compare rodent and human approaches to measure proximal tubule function
- Articulate how ketone bodies are produced and used by the kidneys
Learning Pathway(s)
- Kidney Biology and Physiology
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
Moderators
Presentations
- Ketones and the Kidneys: Fuel for Tubular Metabolic Cross-Talk
10:30 AM - 11:00 AM
- Metabolic Communication by SGLT2 Inhibition
11:00 AM - 11:30 AM
- Role of Tryptophan Metabolism in Kidney Diseases
11:30 AM - 12:00 PM
- Metabolite Secretion by the Proximal Tubule: Importance and Clinical Applications
12:00 PM - 12:30 PM