RE: Pd Question. 3 hours ago

When I was young,many a moon ago we had 7% dextrose PD fluids they really removed volume as long as blood sugar did not shoot up. Anyone still uses...

View Discussion

RE: Pd Question. 6 hours ago

Thanks prof bargman I written name of paper you published( highly educational ) The scenario described above was encountered by myself and despite...

View Discussion

RE: resistant c3gn 6 hours ago

Dr. Gharib - With respect to a "diagnosis" of C3GN, what do make of the reported Fibrillary nature of the deposits (and negative DNAJB9 testing )...

View Discussion

RE: resistant c3gn 6 hours ago

no kappa restriction Frozen tissues consists of up to 4 glomeruli, 1 of which is globally sclerotic. FITC antisera for IgG, IgA, IgM, C3, C1q, ka...

View Discussion

RE: resistant c3gn 7 hours ago

Tough case. You did not give data about light chain staining in the most recent biopsy. Is there kappa restriction. Is there possibility to orde...

View Discussion

RE: resistant c3gn 9 hours ago

IgG subclass and SAP staining, in addition to Pronase digestion and LC staining are definitely indicated . I favor a diagnosis of "concealed " mono...

View Discussion

RE: resistant c3gn 10 hours ago

IgG subclass staining by IF might help. ------------------------------ Emilio Venturelli MD Scuola di specializzazione in Nefrologia, Università...

View Discussion

RE: resistant c3gn 11 hours ago

the igg-kappa is only detectable on IFE-spep varies from normal to slight restriction. KL ratio was 1.05 with normal levels of K and L in 2024. JB9...

View Discussion

RE: resistant c3gn 11 hours ago

Very puzzling case. At this age a PGNMID would be unusual but this is not typical C3GN especially with organized deposits. I am not surprised by th...

View Discussion

Deadline Extension: ASN Loan Mitigation Program 11 hours ago

Greetings everyone, The application deadline for the ASN Loan Mitigation Program has been extended to Wednesday, August 26. This program wi...

View Discussion

Deadline Extension: ASN Loan Mitigation Program 11 hours ago

Greetings everyone, The application deadline for the ASN Loan Mitigation Program has been extended to Wednesday, August 26. This program wi...

View Discussion

resistant c3gn 11 hours ago

Wondering what folks would do with this atypical probable c3GN patient with resistant disease 23 yo female with long history of hematuria and pro...

View Discussion

Last Week to Apply to Participate in the ASN FIT Bowl at Kidney Week 2026 12 hours ago

Hi All, The deadline to apply for the 2026 FIT Bowl is Friday, August 28, 2026, details below. Join the American Society of Nephrology (ASN) Fel...

View Discussion

RE: Pd Question. 14 hours ago

Care of the hospitalised patient receiving peritoneal dialysis: Your questions answered Rehab B Albakr https://orcid.org/0000-0002-8760-5728 and Jo...

View Discussion

RE: ICI induced IgAV 18 hours ago

I would not use CYC in this case. I prefer RTX based on observational studies. No RCT ------------------------------ Richard Glassock MD, FASN Em...

View Discussion

RE: ICI induced IgAV 21 hours ago

Thanks Dr Rodby, I've waited a week his creatinine now slighty up to 290 from 258 umol/l. Would you consider adding anything now or would you wait ...

View Discussion

RE: ICI induced IgAV 21 hours ago

Thank you Dr Glassock. I am hesitant on giving rituximab as I'm a bit worried if he develops a reaction he has limited lung reserve (post partial l...

View Discussion

RE: Pd Question. 1 day ago

Dear Colleagues I totally agree with Dr Bargman and I think to continue with high concentrate solutions for short time mostly get good results e...

View Discussion

RE: Pd Question. 1 day ago

I can't open the attachment that you sent, but I suspect it is by Chan et al about PD in the ICU "Can PD Take the Pressure?". Many (I'm being diplo...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers 1 day ago

Thanks . Dr Saja --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

View Discussion

RE: Pd Question 2 days ago

Removing the external cuff is, in general, of some help i. Curing the exit-site infection; however Pseudomonas infection are very difficult to be c...

View Discussion

RE: Pd Question 2 days ago

No did not remove it. Is it something that needs to be done ? --------------------------------- Muhammad Soobadar MBChB UK ---------------------...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers 2 days ago

I want to share this update on the management of Anti-GBM; still, we are limited by evidence, and all depends on how early the diagnosis and interv...

View Discussion

RE: Pd Question 2 days ago

Did you remove the external catheter cuff? ------------------------------ Giovanni Cancarini Nephrologist Brescia, Italy gcancarini@alice.it ----...

View Discussion

RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 2 days ago

Professor Richard, I agree that we should repeat the biopsy and then decide on the further plan accordingly, especially given the absence of c...

View Discussion

Pd Question. 2 days ago

https://journals.sagepub.com/doi/10.1177/08968608221125714?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#core-bibr44-...

View Discussion

RE: Pd Question 2 days ago

https://pmc.ncbi.nlm.nih.gov/articles/PMC4655795/ --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

View Discussion

Pd Question 2 days ago

Dear colleagues , How long to treat pseudomonas exit site infection in pd patient on APD ? I have a patient who pseudomonas ESI resistant to Cipr...

View Discussion

RE: Pd Question. 2 days ago

Very helpful Paper prof bargman Any colleagues have info/ resource on mesh repair and pd dialysis whether needs holding or not ? Thanks --------...

View Discussion

RE: Pd Question. 2 days ago

Many thanks prof bargman and prof rodby Case 1 Patient was given 48 hr break post pancreatic biopsy . Drain was bloody but settled down day aft...

View Discussion

RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

I have a few questions. This patient has had only one kidney biopsy 8 +years ago showing Class III LN. The Anti-DNA has been negative for oast 8 mo...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

I agree with the hypothetical scenario, except I would use CYC for another 4-week, plus steroids. Not much evidence for RTX in antiGBM with DAH . ...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

Thanks prof glassock the mdt met this afternoon and decided to stop ( personally I would have tried with Atleast 4 weeks of cyclo before calling ...

View Discussion

RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

Thank you for sharing this challenging case. From my perspective, I would consider this SLE-associated secondary TMA with complement amplificatio...

View Discussion

RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

With the strong evidence of serological activity of LN , I am not very confident that a repeat biopsy will contribute much to treatment decision ma...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

Almost 4 weeks dialysis dependent and still not anti-GBM negative. The prognosis for recovery of renal function is very poor, but only the treating...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

22nd July dialysis dependent Post plex ( 3rd or 4th anti gbm level >8) --------------------------------- Muhammad Soobadar MBChB UK -----------...

View Discussion

RE: PR-3 ANCA with lung involvement 3 days ago

The reason i brought up the Rituxvas trial was that they used in the Rituximab arm, IV Cyc day 1 and day 15 .. i thought this was the only rct evid...

View Discussion

RE: PR-3 ANCA with lung involvement 3 days ago

the CYCLOPS trial compared IV to oral CYC in vasculitis in a RCT. The only differences were a lower cumulative dosage in IV and an increae in relap...

View Discussion

RE: PR-3 ANCA with lung involvement 3 days ago

Daily oral CYC was the standard for lupus until the NIH started IV CYC monthly infusions for SLE which gained popularity bc of adherence and ease. ...

View Discussion

RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

Dear Dr. Mohammed, Thank you for your helpful advice. I have also been considering a repeat kidney biopsy and will likely proceed. We will also i...

View Discussion

RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

Dear Professor Glassock, Thank you so much for your feedback on my case. The patient has not received standard triple therapy because treatment...

View Discussion

RE: Obstructing Urinary Stone 3 days ago

Glad she has done well! Would have loved to know what creatinine was prior to stone removal. Just regarding our discussion 😁 -------------------...

View Discussion

RE: PR-3 ANCA with lung involvement 3 days ago

Thank you Prof. Glassock! --------------------------------- Mark Nader MD Germantown TN (201) 805-2000 ---------------------------------

View Discussion

RE: Obstructing Urinary Stone 3 days ago

Both the patient and myself were concerned about the ill effects of untreated presumed complete unilateral urinary tract obstruction by a stone at ...

View Discussion

RE: PR-3 ANCA with lung involvement 3 days ago

Oral was the way CYC was delivered in the trial. There pr is no proven advantages of IV over oral CYC in outcome studies of Vasculitis. In a compli...

View Discussion

RE: Obstructing Urinary Stone Thursday, August 20 @ 9:33 PM

Exactly why an elevated creatinine above baseline in your patient with stone producing unilateral hydronephrosis ( mild to moderate ) on US was con...

View Discussion

RE: PR-3 ANCA with lung involvement Thursday, August 20 @ 9:23 PM

@Richard Glassock , is there a reason you prefer oral cyclophosphamide in this case as opposed to IV cyc x 2 doses such as in the rituxvas trial? A...

View Discussion

RE: anti gbm serology postive with fever and raised inflammatory markers Thursday, August 20 @ 8:15 PM

How long has he been oliguric and requiring dialysis?. Is his antiGBM antibody negative pre-PLEX? ------------------------------ Richard Glassock...

View Discussion

RE: is it lead poisoning? Thursday, August 20 @ 7:58 PM

This is glomerular proteinuria and a near normal plasmal lead. I do not think that further testing is needed. ------------------------------ Ric...

View Discussion