RE: ICI induced IgAV 3 hours ago

The evidence that CYC is effective in IgAV is weak and no data on use in ICI induced IgAV. I would avoid. ------------------------------ Richard ...

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RE: ICI induced IgAV 5 hours ago

Thanks prof glassock Would cancer history also make you stay away from cyclo ? --------------------------------- Muhammad Soobadar MBChB UK --...

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RE: resistant c3gn 5 hours ago

Remember, Pegcetacoplan only treats the C activation, not the underlying cause-in this case possibly a monoclonal disorder. ---------------------...

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RE: cause of AKI 5 hours ago

This seems mist likely due to ashgawandha induced TIN. Prognosis rather poor. ------------------------------ Richard Glassock MD, FASN Emeritus ...

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RE: ICI induced IgAV 5 hours ago

No gross ( macroscopic ) hematuria so a anti-coagulant induced nephropathy is quite unlikely. Crescentic IgAV is very likely the cause of AKI in th...

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RE: ICI induced IgAV 5 hours ago

This is not IgAN, it is IgAV and RTX works very well in IgAV. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen ...

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RE: SGLT2 inhibitors in MCD 5 hours ago

Short and sweet- like Dr. Rodby - NO! ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UC...

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RE: cause of AKI 6 hours ago

this patient is still dialysis dependent and the treating physician felt to do repeat kidney biopsy to see if patient would benefit from MMF as on ...

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RE: SGLT2 inhibitors in MCD 6 hours ago

I would like to paraphrase Dr Hirsch's above. as: no ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush Unive...

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RE: ICI induced IgAV 6 hours ago

"I am hesitant on giving rituximab as I'm a bit worried if he develops a reaction he has limited lung reserve (post partial lobectomy) and that thi...

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RE: ICI induced IgAV 6 hours ago

Dr. Ssa -does oncology believe durvalumab can be permanently discontinued? ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST...

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RE: ICI induced IgAV 7 hours ago

Is the patient on blood thinner ? --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: ICI induced IgAV 7 hours ago

Does ritux work in ig a n? I thought it did not ( La Fayette et al) Not sure about ritux in crescentic ig a What about mmf and steroid ? ----...

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RE: SGLT2 inhibitors in MCD 10 hours ago

As far as I understand this, RAASI and SGLT2Is generally have no significant role at presentation/early in the course of diseases where immunologic...

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RE: resistant c3gn 10 hours ago

some updates repeat complement testing shows some interesting additional findings. + C3 nef (1+) +C5 nef (2+), + C4 nef (1+) . c3 and c4 low, c5 ...

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RE: Alport -FSGS 10 hours ago

Interesting concept - no data. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA Lagu...

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RE: resistant c3gn 11 hours ago

@Richard Glassock i fully understand your reservations , given the lack or organized deposits on the EM . The 15 nm sized deposits suggest fibrils ...

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RE: SGLT2 inhibitors in MCD 11 hours ago

I am not sure if i understood the jist of the question . Is the author suggesting if there is benefit of SGLT2i in patients with complete remissi...

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RE: Alport -FSGS 11 hours ago

If the asymptomatic ( absence of protienuria / hematuria ) - were to test positive for the mutation - would you still treat with with RASi and SGLT...

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Nephrology Quiz and Questionnaire 12 hours ago

Calling all nephrology fellows and program directors-we need your help with the Nephrology Quiz and Questionnaire. Take the quiz today! Each year...

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Nephrology Quiz and Questionnaire 12 hours ago

Calling all nephrology fellows and program directors-we need your help with the Nephrology Quiz and Questionnaire. Fellows, try to outsmart the Nep...

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RE: Alport -FSGS 14 hours ago

Let me say that while a biopsy is NOT needed, if you get positive genetic testing first, these patients usually come to us for proteinuria and get ...

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RE: Alport -FSGS 16 hours ago

Completely agree. Per Kashtan et al. 2018 Kidney International (doi 10.1016/j.kint.2017.12.018) consensus classification Alport syndrome is defin...

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RE: A Young Patient with IgA Nephropathy, Portal Hypertension, and Refractory Anemia: One Disease or Many? 19 hours ago

Distinguished Colleagues, Update on the pending questions. - Alpha globin genotyping (Dr. Glassock): heterozygous −α3.7 deletion, α+ thalassemi...

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RE: Alport -FSGS 23 hours ago

Treatment of FSGS due to X-linked Alport's in a female with RAS-inhibition and SGLT2i inhibitor seems very reasonable especially to reduce proteinu...

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RE: SGLT2 inhibitors in MCD 23 hours ago

I suppose an exception might be made for an ann obese patient with T2DM and MCD, but this is not evidence based. ------------------------------ ...

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RE: SGLT2 inhibitors in MCD 1 day ago

I doubt it . - and the severe proteinuria that exists in MCD would have made patients ineligible for inclusion in the Dapagliflozin and Empaglifloz...

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RE: resistant c3gn 1 day ago

Great discussion of a very complex and nuanced case. C3GN is an enigma inside of a riddle. It seems to be more of a "pattern of injury" rather than...

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SGLT2 inhibitors in MCD 1 day ago

Hello everyone, I would like to know if there is any role for SGLT2 inhibitors in the management of MCD, in addition to the steroids and ACE-I/AR...

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RE: resistant c3gn 1 day ago

Dr. Dastoor - Pegacetocoplan is approved for therapy of C3G or Primary IC-MPGN. How convinced are you that this patient has either of these disorde...

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RE: Alport -FSGS 1 day ago

In a female with a heterozygous pathogenic or likely pathogenic mutation of the COLIV alpha 5 gene and a clinical picture consistent with genetic F...

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RE: Alport -FSGS 1 day ago

In the post hoc analysis ( Yee et al CJASN, 2025) of the DUPLEX study of Sparsentan vs Irbesartan in Alport related FSGS - an antiproteinuric effec...

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RE: Alport -FSGS 1 day ago

Due to random inactivation of the X chromosome, Females with a pathogenic mutation have a mosaic pattern of tissue injury - thus the lack of GBM pa...

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RE: Leukopenia on Hemodialysis 1 day ago

I thought ( as you mentioned) that that was a thing of the past seems in the older less biocompatible membranes: "The goal of these prospective s...

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RE: Alport -FSGS 1 day ago

She has X linked Alports, her brother mist certainly have ESRD from it too. In the absence of biopsy findings of Alport disease , can we attribut...

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RE: resistant c3gn 1 day ago

Pegcetacoplan may be a good idea. there is clearly activation of both classical and Regarding the c5 variant of unknown significance. obviously ...

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RE: resistant c3gn 1 day ago

I am not sure if i would label this as C3G , but rather with a full house pattern i would classify this as IC - MPGN - though both are considered a...

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Alport -FSGS 1 day ago

i have a 45 year old female with hx of mild HTN , since her 4th and final pregnancy in 2010 Since then she has had a slow decline in her renal fu...

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RE: resistant c3gn 1 day ago

Dr. Gharib - you bring up an excellent and important event. The lack of LC monotypism in the frozen IF makes classical PGNMID unlihely. The issue...

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RE: resistant c3gn 1 day ago

Hello David It's a very interesting case. What catches my attention the most and what I would focus on in this case is the reported genetic alte...

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Leukopenia on Hemodialysis 1 day ago

Hello, I had a question regarding Leukopenia and HD patients. Looking at older articles from the late 1970s and 1980s, I found many refe...

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RE: resistant c3gn 1 day ago

Dr. Glassoc - We can not lump all histological and serological data in one diagnosis, so i tried to make the most probable diagnosis Cryoglobuli...

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RE: Pd Question. 1 day ago

For sure recommence the PD (assuming nothing too sinister on the ECG) and assuming volume status isn't an issue, maybe 1.5% / 1.36% q 2 hours and m...

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RE: resistant c3gn 1 day ago

Dr. Charytan Thanks .. The new infirmation heightens my suspicion of anunderlying PGNMID or a "concealed " monotypic IC- MPGN or MN. I do not think...

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RE: resistant c3gn 1 day ago

Nothing in post . ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA Laguna Woods CA (...

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RE: resistant c3gn 1 day ago

Nothing in post. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA Laguna Woods CA (...

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RE: resistant c3gn 1 day ago

------------------------------ Mohamed Gharib MBBS Ain shams university Cairo 01000322177 ------------------------------

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RE: resistant c3gn 1 day ago

------------------------------ Mohamed Gharib MBBS Ain shams university Cairo 01000322177 ------------------------------

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RE: Pd Question. 2 days ago

When I was young,many a moon ago we had 7% dextrose PD fluids they really removed volume as long as blood sugar did not shoot up. Anyone still uses...

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RE: Pd Question. 2 days ago

Thanks prof bargman I written name of paper you published( highly educational ) The scenario described above was encountered by myself and despite...

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