RE: is it SIADH 10 minutes ago

Not to confuse either , using a primary assessment of volume status in " Euvolemic " hyponatremia , is tricky . A distinction between " euvolemic...

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RE: is it SIADH 27 minutes ago

not trying to confuse things Pt is euvolaemic however anti-diuretic hormone is inappropriately secreted. Euvolemia vs mild hypovolemia and be v...

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RE: MPGN pattern in a 43-year-old woman with a JAK2-positive hematologic disorder, portal hypertension, and a serum IgA-λ monoclonal protein 1 hour ago

@Patricia D' Almeida Bianco: Was there any glomerular capillary wall duplication? Did this patient show thrombocytosis at anytime in the setting of...

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RE: Full House/Non Lupus nephropathy 3 hours ago

Thank you Dr Rodby and Glassock Thank you for the articles, have read them. ------------------------------ Sandeep Magoon MD Nephrology Associ...

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RE: C3 or MGRS 9 hours ago

The IgM paraprotein suggests a lymphocytic rather than a plasma cell clone. ------------------------------ Richard Glassock MD, FASN Emeritus Pro...

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RE: is it SIADH 11 hours ago

@Muhammad Soobadar If you have 90 minutes free time , I suggest you review this lecture , which should answer all ( majority) your questions on hy...

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RE: C3 or MGRS 11 hours ago

Dr. Glassock, can you elaborate on why you would consider anti CD20 therapy over antiCD38 for a diagnosis of PGNMID. --------------------------...

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RE: MPGN pattern in a 43-year-old woman with a JAK2-positive hematologic disorder, portal hypertension, and a serum IgA-λ monoclonal protein 12 hours ago

The absence of EM in this case is a significant deficiency that might be remedied by out-sourcing the kidney biopsy material. This is also a classi...

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RE: Refractory membranous Nephropathy 12 hours ago

OBI does not treat immunologically inactive disease with GBM remodeling. No surprise. This is not immunologically refractory MN. Just an opinion. ...

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RE: Refractory membranous Nephropathy 13 hours ago

We did try obi x 2 doses in April. No response at all. --------------------------------- Dr. Hormaz Dastoor. MD, MSc, FASN Divisional Head of Nep...

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MPGN pattern in a 43-year-old woman with a JAK2-positive hematologic disorder, portal hypertension, and a serum IgA-λ monoclonal protein 17 hours ago

MPGN pattern in a 43-year-old woman with a JAK2-positive hematologic disorder, portal hypertension, and a serum IgA-λ monoclonal protein I would a...

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RE: is it SIADH 17 hours ago

Alcohol excess can cause hyponatremia through several mechanisms, the most characteristic is beer potomania (solute-limited water excretion) and va...

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RE: pr3 +ve is it endocarditis ? 17 hours ago

Urine dipstick positive for blood and protein --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: pr3 +ve is it endocarditis ? 17 hours ago

Crp mid 20 --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: pr3 +ve is it endocarditis ? 17 hours ago

Creatine 1.10 Urine acr 0.5 g --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: is it SIADH 19 hours ago

Why would urine (na +k ) 133 be in keeping with SIADH ? interested to learn According to prior research published by Edelman a simplified equati...

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RE: C3 or MGRS 19 hours ago

I am coming to believe that Sanjeev Sethi is correct- Idiopathic (Primary ) IC -MPGN and C3GN are very uncommon "diseases"- best regarded as "patte...

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RE: is it SIADH 19 hours ago

Does nephrostomy trigger ADH? --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: is it SIADH 19 hours ago

@ dr dastoor he is undernourished hit nail on head How does alcohol excess cause hyponatremia? Due to weight loss I have requested whole body CT...

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RE: is it SIADH 19 hours ago

- Why would urine (na +k ) 133 be in keeping with SIADH ? interested to learn . Please correct me if am wrong If hypovloaemic hyponatremia then ...

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RE: C3 or MGRS 20 hours ago

I think this is a case of PGNMID - IgM kappa. . . I would treat with RTX or OBI first. Later maybe with Bendamustine , with Hematology approval. Ju...

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RE: Refractory membranous Nephropathy 21 hours ago

I do not think this is likely to be refractory MN, but is due to chronic remodeling offpermselectivit barrier. You could try OBI but I doubt it wil...

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RE: Suspected COL4 related disease 21 hours ago

Alport syndrom withou hematuria is uncommon but can occur. With Obesity, would definitely consider SGLT2i and GLP1RA. ---------------------------...

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RE: Full House/Non Lupus nephropathy 21 hours ago

Idiopathic IC-MPGN is very rare, if it exists a at all. Over age 50 it is usually a missed diagnosis of PGNMID ------------------------------ Ri...

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RE: C3G Or FSGS 21 hours ago

Great case and good clinical results. Congrats, C3 is just a passive bystander here. Give OBI when he relapses. ------------------------------ R...

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RE: Full House/Non Lupus nephropathy 21 hours ago

From CJASN 19: 743–754, 2024 (also attached) "Nonlupus full house nephropathy is addressed by many different names in the literature." I ha...

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Full House/Non Lupus nephropathy 22 hours ago

Hello Colleagues Question for the group. I have 2 patients 1. Hispanic male 56, saw a couple of years back with nephrotic range proteinuria a...

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RE: is it SIADH 22 hours ago

The question here is how we define SIADH Is it Uosm> 100 mosm/kg , in presence of euvolemic hyponatremia or , is it Uosm > Posm , as per Eu...

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RE: Suspected COL4 related disease 23 hours ago

I don't have the dipstick result but there was no red cell on any specimen..her BMI is 32 kg/m2 ------------------------------ Safa Nowrooz MD Dr...

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RE: C3 or MGRS 23 hours ago

Just to give a follow up on the case . The patient was first diagnosed with a MPGN pattern of injury , and Kappa restriction on IF . EM showed si...

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RE: Refractory membranous Nephropathy 23 hours ago

Just as a follow up and seeking further advice on this case , This patient with MN has turned antiPLA2r negative since 2023 , has also been TH...

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RE: treatment of PLA2R positive Membranous in Hepatitis B carrier 23 hours ago

the membranous is biopsy proven Details of Hepatitis B infection: Initial evaluation (about 6 months ago): Hep B surface antigen and HBV PCR po...

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RE: C3G Or FSGS 1 day ago

Just as a follow up , the patient was admiited to the hospital 2 weeks ago , as AKI and 10 grams of protienuria He was treated with pulse steroi...

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RE: treatment of PLA2R positive Membranous in Hepatitis B carrier 1 day ago

If PLA2R and urine protein are decreasing, with well preserved renal function and only mild hypoalbuminemia, do not see need for immediate rituxima...

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RE: treatment of PLA2R positive Membranous in Hepatitis B carrier 1 day ago

@Roger Rodby Thanks for the appreciation. But please note that tatooing itself has been associated with the spread of HBV. ----------------------...

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RE: Tablo HD machine 1 day ago

thank you so muchchris frankel

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RE: is it SIADH 1 day ago

Agree fits SIADH clinically and meds the only question here is out whether treat or not. ------------------------------ Roger Rodby MD, FASN P...

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RE: maintenance for PR3 ab AAV? 1 day ago

14 years with no PR3 AAV relapse on prednisone alone, only 5 mg. considerations to stop prednisone altogether and watch or stop prednisone and us...

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RE: Tablo HD machine 1 day ago

Thank you Dr Balan..helps very much....Prem Chandran

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RE: treatment of PLA2R positive Membranous in Hepatitis B carrier 1 day ago

@Satish Balan thanks for the info sheet. I wil distributie it to our faculty and fellows And wil have it tattooed on my arm ----------...

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RE: Tablo HD machine 1 day ago

The older discussion is here https://community.asn-online.org/discussion/tablo-dialysis-machine?hlmlt=VT ------------------------------ Sati...

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maintenance for PR3 ab AAV? 1 day ago

I have a 79 yo patient who has PR3 ab AAV with pulm/renal involvement during initial presentation back in 2009 which was treated with cytoxan/stero...

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RE: is it SIADH 1 day ago

"question is this SIADH" current data meets requirements, serum uric acid and or FEurate would be helpful. sertraline is common cause and if patien...

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RE: is it SIADH 1 day ago

With hyponatremia of this duration and a U [Na + K] of 133, while serum Na is < 130 and an elevated U osm this is likely SIADH. -----------------...

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RE: treatment of PLA2R positive Membranous in Hepatitis B carrier 1 day ago

Thank you Dr Rodby. Unfortunately here we are not sure what exactly is the situation here. Help B carrier status means HbSAg positivity with or wit...

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RE: pr3 +ve is it endocarditis ? 1 day ago

What is serum creatinine , urine sediment, UPC and UAC ? CRP? ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST KPCOP EC [P...

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is it SIADH 1 day ago

Right PUJ obstruction presenting with ruptured pelvic system June 2024 - managed with nephrostomy - waiting list for robotic pyeloplasty and admitt...

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RE: pr3 +ve is it endocarditis ? 1 day ago

any thoughts about kidney biopsy? ------------------------------ Muhammad Soobadar MBChB UK ------------------------------

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RE: pr3 +ve is it endocarditis ? 1 day ago

PET Scan Persistent FDG activity posterior to the pacemaker/ICD box in the chest wall which has mildly increased since 2023. This can indicate a ch...

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RE: treatment of PLA2R positive Membranous in Hepatitis B carrier 1 day ago

HBsAg + and HBV-DNA PCR negative usually occurs on anti-viral therapy and may be due to persistence of HBV in liver cells, without viremia but with...

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