RE: PLA2R negative Membranous Nephropathy- Management Q 5 minutes ago

Thank you, have put in for Obi prior Auth. Have a great weekend. ------------------------------ T. Kaur, MD FACP Nephrologist/HTN/Kidney Stones ...

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RE: PLA2R negative Membranous Nephropathy- Management Q 45 minutes ago

Will Felzartamab gain approval for MN from FDA by comparison to a CNI ?. If so . the approval will be meaningless. The comparator will have to be O...

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RE: PLA2R negative Membranous Nephropathy- Management Q 1 hour ago

Regardless of PLA2Ra positive or other. This is an antibody driven disease and therapy is targeting the antibody producing cells. I agree with abov...

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RE: PLA2R negative Membranous Nephropathy- Management Q 1 hour ago

I fully agree with Dr. Rodby- a CR with RTX makes Cancer less likely but either way with NELL1 disease you have to look hard for triggers. Mercury ...

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RE: PLA2R negative Membranous Nephropathy- Management Q 3 hours ago

As you know, Nell1 MGN is Cancer, medications, herbals, Hg containing skin creams, lipoic acid, ask about everything... It is often segmental and...

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RE: PLA2R negative Membranous Nephropathy- Management Q 3 hours ago

Biopsy is NELL 1 positive. THSD7A negative. Does that change the management? Cancer screen was negative. still Ola to watch he proteinuria a...

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RE: Latent TB and Membranous Nephropathy 18 hours ago

Yes Quantiferon is part of screening in our hospital. I do it because , it avoids conflict with the infusion and ID teams who have created the prot...

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RE: Latent TB and Membranous Nephropathy 20 hours ago

Thanks Quantiferon is not part of pre rituxan screen in my centre --------------------------------- Muhammad Soobadar MBChB UK ----------------...

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RE: Latent TB and Membranous Nephropathy 20 hours ago

YES, especially when steroids are used n conjunction with a CNI. I would definitely avoid any CNI or steroid use in this patient ---------------...

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RE: pr3 +ve is it endocarditis ? 22 hours ago

well PTH was not suppressed and urine calcium was borderline high so could be primary HPTX especially since serum phos low. eGFR 65 with creatinine...

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RE: Latent TB and Membranous Nephropathy 23 hours ago

Is Cni risk higher than rituxan for latent tb reactivation prof glassock --------------------------------- Muhammad Soobadar MBChB UK ---------...

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RE: Latent TB and Membranous Nephropathy 1 day ago

I would not advise use of a CNI,especially with steroids, for MN in a patient with latent TB. Just an opinion. ------------------------------ Ri...

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RE: pr3 +ve is it endocarditis ? 1 day ago

Prior to cinecalcet --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: Latent TB and Membranous Nephropathy 1 day ago

Respiratory MDT Reviewed case Agree TB highly unlikely given reassuring CT, stability of bronchiectasis and only Sx weight loss Given product...

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RE: Latent TB and Membranous Nephropathy 1 day ago

Thanks Dr. Dastoor fir your commentary on this case.. It is not uncommon to see combinations of CNI and RTX used to "speed up" the trajectory towar...

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ASN Loan Mitigation Program 1 day ago

ASN is now accepting applications for the ASN Loan Mitigation Program as a part of its continued efforts to decrease the loan burden of those enter...

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RE: Latent TB and Membranous Nephropathy 1 day ago

Couple of questions 1. Was the Quantiferon checked , because you planned to give Rituximab or because of his symptoms of chronic cough and weight...

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RE: pr3 +ve is it endocarditis ? 1 day ago

Was serum calcium and urine calcium prior to or after cinecalcet? ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST KPCOP E...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 1 day ago

I am grateful for your input to help me with this case. The platelets are normal @ Dr.Soobadar. ------------------------------ Safa Now...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 1 day ago

If I am not mistaken the malignancy seems to have predated the onset of suspected Membranous Nephroapthy by a relatively long duration. I would con...

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RE: Latent TB and Membranous Nephropathy 1 day ago

Thanks prof glassock He is on treatment dose enoxparin So you would not do PET or bronchoscopy ? CTTAP - -ve Psa negative No breast lump Us...

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RE: Latent TB and Membranous Nephropathy 1 day ago

I would treat with RTX in the absence of any positive screenings for occult cancer .. ------------------------------ Richard Glassock MD, FASN Em...

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RE: Latent TB and Membranous Nephropathy 1 day ago

With a negative tissue PLA2R I see no point in repeating the serum Anti-PLA2R . With the severe NS I would not wait too long before treating with R...

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RE: Latent TB and Membranous Nephropathy 1 day ago

Cannot do thrombospondin --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: Latent TB and Membranous Nephropathy 1 day ago

“Ibwoiul repeat tgecdeerumbPLA2R one by ELISA” What do you mean prof glassock --------------------------------- Muhammad Soobadar MBChB UK ----...

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RE: Latent TB and Membranous Nephropathy 1 day ago

Plar 2 negative biopsy Request for nel . They can do either serum or tissue thrombospondin --------------------------------- Muhammad Soobadar M...

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RE: Latent TB and Membranous Nephropathy 1 day ago

I think the TB findings are co-incidental and not causal. This is pretty advanced Dusease. Let's see what the PLA2R is in glomeruli first. I would ...

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RE: pr3 +ve is it endocarditis ? 1 day ago

Calcium 2.91( 2.20-2.60) --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: pr3 +ve is it endocarditis ? 1 day ago

Bilirubin 12(5-21) Ferritin 238 (30-337) Yes have access to measured gfr but not sure how fast it will be done Are you thinking if mgfr low then k...

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RE: pr3 +ve is it endocarditis ? 1 day ago

What was the serum calcium when the PTH was 8? ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medic...

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RE: pr3 +ve is it endocarditis ? 1 day ago

Improving calcium with cinecalcet not fluids 24hr urine for calcium 6.11(2.5-7.5) 24 hr volume 2.74 L Urine calcium 2.23 mmol/L ----------------...

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RE: pr3 +ve is it endocarditis ? 1 day ago

Chloride normal Pth 8 ( 1.5-7.6) Vitamin D 111 mmol/L 1-25 OH pending --------------------------------- Muhammad Soobadar MBChB UK ----------...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 1 day ago

Isn't this most likely PLA2R+ MN in a Patient with MDS? The choice of RTX for initial therapy seems quite reasonable, especially in the face of a d...

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RE: Latent TB and Membranous Nephropathy 1 day ago

------------------------------ Muhammad Soobadar MBChB UK ------------------------------ Files Attached DocumentRE: Latent TB and Membranous Nephro...

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Latent TB and Membranous Nephropathy 1 day ago

87M. CKD 4 , TCC bladder, BPH, HTN, AF, Diverticular disease. Bronchiectasis Been under review since April with nephrotic syndrome (oedema starte...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 1 day ago

If I were to use ritux I would consult with haematology as alluded by prof rodby first --------------------------------- Muhammad Soobadar MBChB ...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 1 day ago

I am not sure I would treat fsgs with normal albumin with IS Same vein here not sure if patient is not nephrotic with MN and has RVT , drug use , ...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 1 day ago

Dr. Soobadar. Can you expend more on the origin of your concern about use of RTX in a patient with Myelodysplsstic Syndrome? Also , bilateral RCT w...

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RE: pr3 +ve is it endocarditis ? 1 day ago

Thanks for the nice compliment!! I a not sure that Claude want my advice, but ai do try to keep him/her/it UpToDate. See you in Maui soon. ...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 2 days ago

Thanks for case Humble thoughts. Would you proceed with rituximab despite his underlying MPN and possible malignancy? I would not as albumin No...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 2 days ago

------------------------------ Safa Nowrooz MD Sanad 0097339873113 ------------------------------

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 2 days ago

Yes, the albumin level has been normal throughout the follow up period, I just discovered that the full table was not displayed ----------------...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 2 days ago

Dr. Nowrooz's initial post mentions "normal" liver function tests and serum protein electrophoresis. I assume this also means normal serum albumin ...

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RE: C3G Or FSGS 2 days ago

I think there is a consensus that this is primary FSGS, explosive presentation with heavy proteinuria and hypoalbuminemia. The C3 in the kidney at ...

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RE: pr3 +ve is it endocarditis ? 2 days ago

@Richard Glassock, with all due respect, Claude should be consulting you. ------------------------------ Roger Rodby MD, FASN Professor of Medic...

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RE: Anti-PLA2R antibody +ve MN on a background of malignancy 2 days ago

There is a increased prevalence of cancer in PLA2R patients but I am not convinced it is pathogenic (See attached) I dont trust PLA2R titer of (...

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RE: C3G Or FSGS 2 days ago

The degree of C3 staining (occasional, 1-2+ segmental) with some mesangial hypercellularity and the absence of electron dense deposits to me is not...

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RE: C3G Or FSGS 2 days ago

Please see attached biopsy reports .. Am actually on vacation without a laptop and can't post the biopsy into the body of this message . Thanks ...

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Anti-PLA2R antibody +ve MN on a background of malignancy 2 days ago

Mr. G.N. is a 74-year-old gentleman with the following past medical history: Peripheral vascular disease (right-sided claudication that did not r...

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RE: C3G Or FSGS 2 days ago

A difficult case to classify, but in my opinion this is most compatible with a presentation of Primary FSGS, not C3GN. Isolated deposits of C3 have...

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