RE: de-novo MGRS with LCDD 11 minutes ago

I'm a bit lost in all of these abbreviations but I dont see how this is not recurrent disease. Isnt this the classic presentation? This is th...

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RE: Dapagliflozin In Hd Patient With Diastolic Dysfunction 2 hours ago

Dr. Soobadar. What did you do with the SGLT2i suggestion for therapy of HFpEF in your oliguric patient with ESKD treated by HD ? Just curious. ...

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RE: secondary IgA Nephropathy 3 hours ago

But the issue here is the unexplained disparity between Scr and the very benign kidney biopsy findings , the latter perfectly compatible with very ...

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RE: de-novo MGRS with LCDD 3 hours ago

In this case it is difficult to determine whether this is de novo or recurrent LCDD - an underlying low grade lymphoma prior to transplant cannot b...

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RE: Colleague Managing Home Hd Cohort 3 hours ago

Jorge: I recognize & value you decade's of experience with home HD & agree with almost everything you stated. Except with regard to button-hole tec...

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RE: IgA-Nephropathy: to complement or not to complement? 3 hours ago

Dr. Dastoor- thank you very much for your comments and opinions. I tend to agree with you that a re-biopsy in this patient might be useful, but I w...

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RE: IgA-Nephropathy: to complement or not to complement? 3 hours ago

Thanks Dr. Kuhn- both my good, now departed, friend Barry Benner and I appreciate these comments . ------------------------------ Richard Glassoc...

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RE: de-novo MGRS with LCDD 4 hours ago

@Richard Glassock, @Nelson Leung @RogerRodby @KKVenkat @MarioRubin ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] ...

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de-novo MGRS with LCDD 4 hours ago

eetings colleagues I would like to share the following interesting patient 59 y/o ESRD presumed DN s/p DDTx 9/2024 cb DGF and Bx r/o reject...

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RE: Colleague Managing Home Hd Cohort 4 hours ago

Dr Chadran and group : My experience in Home hemo is very old , over 35 years ago! We preferentaly trained Patient to do self sticks, seldom had pa...

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RE: de-novo MGRS with LCDD 4 hours ago

i would have loved to see BMBX when IGK spike and hypercalcemia. would get BMbx now . what is SLC ,SPEP now ? sorry what is current IS? what does m...

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RE: secondary IgA Nephropathy 5 hours ago

Immune complex GN can recover spontaneously after the offending antibody is stopped, not sure if all affected gloms will recover, some will be fibr...

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RE: IgA-Nephropathy: to complement or not to complement? 5 hours ago

Thank you all for sharing your expertise. I will therefore refrain from starting iptacopan and instead apply for reimbursement for sparsentan (I am...

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RE: IgA-Nephropathy: to complement or not to complement? 5 hours ago

True , but the uPCR and eGFR data did show benefit for patients with S1 and T1 lesions . Though this patientbhaf an inadequate biopsy, I think if w...

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RE: IgA-Nephropathy: to complement or not to complement? 7 hours ago

Is it easier to obatin approval for Iptacopan than for Tirzepatide? ------------------------------ Awais Nauman HMC Doha ------------------------...

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RE: de-novo MGRS with LCDD 7 hours ago

Correction UPCR has been low grade 150 to 250 mg/ gm ------------------------------ Jonathan Slater MD Renal & Transplant Associates of New...

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de-novo MGRS with LCDD 8 hours ago

Greetings colleagues I would like to share the following interesting patient 59 y/o ESRD presumed DN s/p DDTx 9/2024 cb DGF and Bx r/o reje...

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RE: IgA-Nephropathy: to complement or not to complement? 11 hours ago

Here is my specific question- in the published 24 month eGFR slope data from the NEJM APPLAUSE report can you infer a benefit (attenuation of the s...

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RE: IgA-Nephropathy: to complement or not to complement? 11 hours ago

Show me some data that Iptacopan has benefits in patients without inflammation and low grade but fluctuating proteinuria with stable eGFR and I wou...

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RE: IgA-Nephropathy: to complement or not to complement? 13 hours ago

@Richard Glassock I agree with you in that the patient will benefit from addition of ET1 - either Sparsentan or Atrasentan and perhaps a ns- MRA as...

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RE: IgA-Nephropathy: to complement or not to complement? 13 hours ago

I would not use Iptacopan in this case, because of the absence of inflammatory signs ( no hematuria , no crescents, ) , the predominance of glomeru...

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IgA-Nephropathy: to complement or not to complement? 14 hours ago

I would appreciate your input regarding a 33-year-old patient with biopsy-proven IgA nephropathy. His first symptoms occurred in 2014, at the age ...

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RE: secondary IgA Nephropathy 18 hours ago

Thanks. Eagerly awaiting results. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA L...

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RE: Intersting case-Need your opinion 20 hours ago

Thank you for everyones opinion. I agree Eculizumab dose may be inadequate based on the blood test results. CH50 level was done as per instruct...

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RE: secondary IgA Nephropathy 20 hours ago

Dr Glossock, I called and asked him to do labs which he agreed to do on Friday. Thank you ------------------------------ Radhika Thalla MD Phy...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 21 hours ago

Yes, she's on MMF, prednisone 5 mg,, her last dose of Belatacept was June 20 ------------------------------ Vijayakumar Paramasivam MD Nephrologi...

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RE: secondary IgA Nephropathy 21 hours ago

Dr. Thalla- Do you have any additional follow up information to post- like serum Cystatin C, fasting serum creatinine, or 24 hour endogenous crea...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 23 hours ago

Thanks-does she remain on MMF and low dose steroids ? is eGFR stable? is neurologic condition still improving? ------------------------------ ...

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RE: Intersting case-Need your opinion 23 hours ago

thanks Dr. Grimm, the exact concern in my post above "The high C5b-9 levels suggest the Eculizumab is not very effective which could be due to prot...

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RE: Intersting case-Need your opinion 23 hours ago

In addition to the CH 50 level, which should be low, you can actually send Eculizumab trough levels to Cincinnati Children's Hospital. 99 µg/...

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RE: Intersting case-Need your opinion 1 day ago

Thank you Dr Glassock. Your clarification much appreciated in this area of secondary aHUS as you precisely stated... ----------------------------...

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RE: IgAN case 1 day ago

In small short term studies from China HCQ lowers proteinuria but its long term effects on GFR are unknown. Combination therapy with modern approve...

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RE: Intersting case-Need your opinion 1 day ago

Dr. Chandran- my apologies for not having responded to your excellent question in May, within this thread . I must have mussed it. My comment was m...

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RE: IgAN case 1 day ago

Would you please share with us more details about the repeat biopsy results, persistent or worsening heavy proteinuria in the nephrotic range, whic...

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RE: IgAN case 1 day ago

I don't believe she is in the resolving phase, especially considering she had nephrotic-range proteinuria. Persistent hematuria, along with stable ...

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RE: IgAN case 1 day ago

would use low dose steroids and MMF 1.5 gms daily. Dr. Glassock what do you think about adding HCQ ? doi: 10.3389/fimmu.2026.1783946 ------...

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RE: IgAN case 1 day ago

I would start MMF right now. Just an opinion. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medici...

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RE: IgAN case 1 day ago

If the patient is not obese, then SGLT2i therapy may not needed. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geff...

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RE: IgAN case 1 day ago

Yes, I'm very concerned of her current condition. My goal is to subside this acute flare (seems to be in the resolving phase) and eventually preser...

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RE: IgAN case 1 day ago

Thank you professor Glassock. You prefer a moderate dose of steroid. When would you start MMF? ------------------------------ Tuan Nguyen DO AN M...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 1 day ago

Avoiding an mTOR inhibitor as first choice given her nephrotic-range proteinuria and advanced IFTA, where it is likely to worsen proteinuria and be...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 1 day ago

2019 txp biopsy showed - cni toxicity Renal Allograft, core biopsy (diagnosis based on light microscopy only): - Negative for acute rejection. -...

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RE: Colleague Managing Home Hd Cohort 1 day ago

"Is there a preferred needling technique" : depends on your nursing personnel who trained the patient. There are several differences between center...

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RE: Intersting case-Need your opinion 1 day ago

Jagdeesh: The reason I asked about which lab did the assay is that C5b-9 is notoriously difficult an assay to do & standardize. The serum collectio...

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RE: Dapagliflozin In Hd Patient With Diastolic Dysfunction 1 day ago

@ dr Dastoor Thanks I used dapa in kidney clinic ( practice of unit ) Cardiology also mentioned dapa and finenorone but not great evidence based ...

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RE: Intersting case-Need your opinion 1 day ago

Has the genetic study reported any C5 variants that cause unresponsiveness to eculizumab? That could be a factor here too. There is persistent hemo...

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RE: CAKUT, pediatric neph input 1 day ago

@Guido Filler - what about hepatomegaly ? ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST KPCOP EC [Past Medical Director ...

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RE: CAKUT, pediatric neph input 1 day ago

Dear Varsha, This is an interesting presentation. I suspect that the small right kidney explains his reduced GFR and perhaps some of the proteinuri...

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RE: IgAN case 1 day ago

Seems to be a very high risk patient . I would seriously consider pulse steroids , followed by Testing dose dose steroids and MMF. If no response...

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RE: Dapagliflozin In Hd Patient With Diastolic Dysfunction 1 day ago

@Muhammad SoobadarI mentioned dapa , as there is some data on its safety in ESRD patients . In the case of Empa such data seems to be lacking . Hen...

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