RE: IgA Nephropathy 23 minutes ago

Thanks. I have doubts that SGLT2i or NS- MRA are doing anything and might even be stopped. If his 24 hour urine Na is elevated, I would start with ...

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RE: IgA Nephropathy 2 hours ago

His BMI is 28, previously 1 year ago was 30. Since then he has lost 6 kg.. There is no hematuria or hemoglobinuria on more than 2 occasions Hi...

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RE: Conventional treatment resistant Anti GBM disease 3 hours ago

Very interesting developments!! Thanks for sharing . Of course, , one cannot be sure that the Eculizumab is causally related to the apparent improv...

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RE: Conventional treatment resistant Anti GBM disease 4 hours ago

As a follow up on this patient who was started on Eculizumab - I have some encouraging developments. I used 600 mg Eculizumab 16 days ago and there...

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RE: IgA Nephropathy 4 hours ago

What is his BMI? What us his dipstick hemoglobinuria on at least two specimens? Has his eGFR changed iver 1 year of therapy? Does he use excessive ...

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RE: Interpretation Of Mainritsan 2 4 hours ago

The trial was powered to detect a 20% or gesrer difference in the relapse rate (BVAS based) between the two groups (CD19 B cell tailored vs fixed d...

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RE: diagnosis? 5 hours ago

Both Bartter syndrome and Dent's disease are quite rare and therefore there can't be any RCT. Here is an article on Dent's disease. Asha Moudgil Fi...

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RE: diagnosis? 5 hours ago

Most kids with Bartter syndrome have marked hypokalemia, and it is very difficult to control their K levels. We have to put G-Tubes in infancy to g...

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RE: diagnosis? 5 hours ago

These kids are polyuric if I recall correctly and that can lead to subtle dehydration and may cause increase in renin levels. Will do a literature ...

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RE: diagnosis? 6 hours ago

65 inches height would me short in The Netherlands but not so uncommon in Pakistan. I suspect spot urine electrolytes would suffice. ----------...

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RE: diagnosis? 6 hours ago

This is an amazing case, thanks so much for posting it. slightly high ACE level doesnt excite me, life threatening hypokalemia with metabolic ...

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RE: anti gbm/mpo +ve in young female 6 hours ago

Can you provide reference for the article since I can't see your paper. Thanks ------------------------------ Asha Moudgil MD, FASN Children nat...

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RE: diagnosis? 6 hours ago

Urine for beta-2 microglobulin is elevated in Dent's disease. Therefore checking for that might be helpful while you are waiting for genetic test r...

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IgA Nephropathy 6 hours ago

I have a 42 year old male patient . His eGFR is 78 ml/min . No hematuria Kidney biopsy done in Jan 2026 showing IgA Nephropathy . No sclerosed...

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IgA Nephropathy 6 hours ago

I have a 42 year old male patient . His eGFR is 78 ml/min . No hematuria Kidney biopsy done in Jan 2026 showing IgA Nephropathy . No sclero...

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​​​ASN Publications Training Programs: Call for Applications Opens March 2 7 hours ago

The ASN Publications Portfolio (JASN, CJASN, Kidney360, and ASN Kidney News) will open their "Call for Applications" on March 2 for their 2-year ed...

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​​​ASN Publications Training Programs: Call for Applications Opens March 2 7 hours ago

The ASN Publications Portfolio (JASN, CJASN, Kidney360, and ASN Kidney News) will open their "Call for Applications" on March 2 for their 2-year ed...

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​​​ASN Publications Training Programs: Call for Applications Opens March 2 8 hours ago

The ASN Publications Portfolio (JASN, CJASN, Kidney360, and ASN Kidney News) will open their "Call for Applications" on March 2 for their 2-year ed...

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RE: Fibrillary glomerulonephritis recurrence in a kidney transplant 9 hours ago

I would proceed with OBI therapy. Just an opinion ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 -------...

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RE: Fibrillary glomerulonephritis recurrence in a kidney transplant 9 hours ago

Thank you Dr. Glossock. Our pathologist repeated the IF for light chains (without pronase digestion). This time, there is deposition of LC kappa (...

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RE: Interpretation Of Mainritsan 2 11 hours ago

Is serious adverse reaction rate being higher in fixed dose statistically significant ? Is it clinically significant ? Many thanks --------...

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RE: Interpretation Of Mainritsan 2 11 hours ago

Sorry relapse rate 17.3 % in tailored and 9.9 % in fixed regime group --------------------------------- Muhammad Soobadar MBChB UK ------------...

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Interpretation Of Mainritsan 2 12 hours ago

Abstract Objective To compare individually tailored, based on trimestrial biological parameter monitoring, to fixed-schedule rituximab reinfusion...

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RE: diagnosis? 12 hours ago

Five feet five inches tall seems low. Does he have any unaffected siblings? If so, how tall are they? The genetic tests will be crucial. I am prett...

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RE: diagnosis? 15 hours ago

He does not have growth retardation , his height is 5 feet 5 inches , weight is around 70 Urinary chloride was not run in 24 hours sample, kits out...

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RE: Mesangioproliferative immune complex GN with full house on IF but with negative serologies including ANA. 21 hours ago

Will check with pathologist regarding doing pronase digested work up. Thank you Dr Glassock. ------------------------------ Vikram Beemidi MD MD ...

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RE: FSGS in partial remission . what next 22 hours ago

I agree that this patient fulfills the criteria for categorizing her disease as Primary (permeability factor related) FSGS. A genetic cause is very...

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FSGS in partial remission . what next 23 hours ago

In May 2023 I was referred 30 year old white female with sudden onset of nephrotic syndrome with profound proteinuria (11.5gm with 8.1gm albumen/da...

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RE: Mesangioproliferative immune complex GN with full house on IF but with negative serologies including ANA. 1 day ago

In a patient of this age and kidney pathology I always wonder about Concealed PGNMID. I would do a Pronase digested Paraffin IHC for monotypic LC a...

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RE: diagnosis? 1 day ago

If no growth retardation is present and genetic studies are negative, then a rare form of Adult acquired Bartter -like syndrome needs to be conside...

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RE: diagnosis? 1 day ago

Almost certainly congenital with such prominent nephrocalcinosis. Metabolic alkalosis with hypokalemia and hypercalciuria suspicious for Bartter....

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Mesangioproliferative immune complex GN with full house on IF but with negative serologies including ANA. 1 day ago

Appreciate input from ASN Community regarding management of this patient. 71-year-old female patient with past medical history significant for hy...

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RE: anti gbm/mpo +ve in young female 1 day ago

Thanks. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 ------------------------------

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RE: Full house with negative serolgy 1 day ago

I need to clarify my response- RF levels are usually normal in APSGN and in infection related IgA dominant GN. So the " RF rule" is not valid in al...

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RE: anti gbm/mpo +ve in young female 1 day ago

Just send the paper in gmail accountBajinder Sent from my iPhoneSpelling mistakes are regretted which are not intentional

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RE: anti gbm/mpo +ve in young female 1 day ago

Thanks. Who is the first author so I can find the paper on PubMed?. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949...

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RE: Full house with negative serolgy 1 day ago

Thanks really helpful --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: anti gbm/mpo +ve in young female 1 day ago

See this paper Glomerular disease journal 2025) 5(1) 68-73 Mitigated clinical course of crescentic GN with antigbm positive ----------------------...

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RE: diagnosis? 1 day ago

Both secondary hyperaparathyroidism and elevated levels of 1,25 dihydroxy Vitamin D can be found in Bartter syndrome and are linked to hypercalciur...

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RE: Full house with negative serolgy 1 day ago

I agree fully with Dr. Rodby's concerns. If the RF is normal an underlying IRGN is very unlikely,n especially if C3/4 levels are also normal.. just...

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RE: Full house with negative serolgy 1 day ago

I think you have to be VERY careful to not miss an IRGN, especially the culture negative endocarditis related infections. We have diagnosed more th...

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RE: Full house with negative serolgy 1 day ago

@ dr Sara / colleagues thanks for case Concerning your question about infection if patient has sign of infection ( symptoms , or fever or clinical ...

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RE: diagnosis? 1 day ago

And where will we fit high pth and high 1,25 hydroxy VIT d3 with diagnosis of barrter? Yahoo Mail: Search, organise, conquer On Thu, 19 Feb 20...

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RE: diagnosis? 1 day ago

I will check urine chloride , Can we use nsaids for prolong period with this creatinine and marked nephrocalcinosis? Yahoo Mail: Search, organise,...

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RE: diagnosis? 1 day ago

Another diagnosis would be Dent Disease, as this genetic disorder can also present with Bartter -syndrome like features. Generic treating shoukd he...

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RE: diagnosis? 1 day ago

I would give serious consideration to a diagnosis of Bartter Syndrome, Type 1 or 2. Can you obtain genetic studies?. What is the urinary chloride e...

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diagnosis? 1 day ago

33 years old male with no prior co morbidities was admitted twice in outside facility with hypokalemic periodic paralysis twice requiring intubatio...

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RE: Management of persistent amyloidosis and nephrotic range proteinuria despite Very good partial response to BMT and prior chemo 1 day ago

Hi Dr Mohiuddin thanks for reply What was her proteinuria level before bone marrow transplant and albumin ? Then one year after and 18 month after...

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RE: Management of persistent amyloidosis and nephrotic range proteinuria despite Very good partial response to BMT and prior chemo 1 day ago

Auto BMT was in March 2023. Sent from my iPhone

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RE: Salmonella Sepsis and C3 GN???? 1 day ago

Should gear to biopsy ( not hear) Thanks --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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