RE: Post-Preeclampsia TMA Pattern vs. INF2 Podocytopathy: A Diagnostic Dilemma 42 minutes ago

Dear Dr. Moreno, Could you provide more details about the pregnancy episode? Did the patient have a miscarriage or lost , preeclampsia or HELL...

View Discussion

RE: GN in post transplant 45 minutes ago

This report is about TCMR (not ABMR). Will await what additional (I have already queried Dr. Solez who founded BANF) experienced renal pathologists...

View Discussion

RE: GN in post transplant 1 hour ago

Never. See the BANF ABMR agreed upon diagnostic criteria. Let's call a friend for further details:@Kim Solez ------------------------------ Mario...

View Discussion

RE: GN in post transplant 1 hour ago

Dr. Glassock: There is nothing new under the sun! Very rare, but crescents have been reported in rejection. Never seen one myself. https://kidney...

View Discussion

RE: GN in post transplant 1 hour ago

Cellular crescents in ABMR - how often does that happen? ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen Schoo...

View Discussion

Post-Preeclampsia TMA Pattern vs. INF2 Podocytopathy: A Diagnostic Dilemma 1 hour ago

Hello, I would like to share a clinical case with the community: A 36-year-old female, first pregnancy (May 2025) complicated by severe preec...

View Discussion

RE: GN in post transplant 3 hours ago

Now I have read biopsy report - unless I missed it was C4d in peritubular capillaries.? Would consider MMDX ( molecular biopsy ) if available at yo...

View Discussion

RE: GN in post transplant 3 hours ago

Can I assume that BKPCR was done and negative and biopsy contained enough tissue for SV40 stains for BK were negative. If so, would get DD-cfDNA an...

View Discussion

RE: Transplant 4 hours ago

Thanks Roger, I completely understand, but was just trying to see if I could get people to post their transplant cases in both the open form and th...

View Discussion

RE: GN in post transplant 17 hours ago

That's a good point. I will discuss with my pathologist more on that Thank you

View Discussion

RE: Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 18 hours ago

I agree that the treatments he has received would have been used for IT Glomerulopathy as well. I suppose that the next therapy would be a stem cel...

View Discussion

RE: Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 21 hours ago

Haha, I feel the same way about C-P! But just trying to provide intelligent feedback to the patient (a colleague) and the heme-onc colleague. But I...

View Discussion

RE: Transplant 23 hours ago

Mark, We have tried for years to get people to post in one of the various specific forums, AKI, Transplantion, Fellowship training, Oncology nep...

View Discussion

RE: Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 23 hours ago

I hope this does not come across as flippant, but you have on your side one of the strongest renal pathology departments in the world at Columbia. ...

View Discussion

RE: GN in post transplant 23 hours ago

My initial reaction was to make sure he did not have an infection (RF echo) and treat with Pexivas vasculitis protocol,. but then I read Dr Venkat'...

View Discussion

RE: GN in post transplant 1 day ago

In the setting of chronic/intermittent CMV viremia, and heavy proteinuria despite advanced renal dysfunction, need to consider collapsing glomerulo...

View Discussion

Subnephrotic Proteinuria Unmasked by Preeclampsia: A Dual Genetic Hit of INF2 and CFHR1/CFHR3 Deletion 1 day ago

Deleted. ------------------------------ Santiago Moreno Tobon MD Fundación Santa Fe de Bogota Bogotá (313) 421-0693 --------------------------...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

Obviously I didn't think that through. I agree that X linked seems unlikely with a paternal inheritance. Also the actual relationship of the uncles...

View Discussion

GN in post transplant 1 day ago

hello everyone Would appreciate input on this challenging case 58 year old male with hx of ESKD 2/2 anti-GBM disease, B/L native nephrect...

View Discussion

GN in post transplant 1 day ago

Hello everyone Would appreciate the input on this challenging case 58 year old male with hx of ESKD 2/2 anti-GBM disease, B/L native nephrec...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

The one unresolved issue is father to son inheritance, that should not occur in pure X-linked disease, ------------------------------ Richard Gla...

View Discussion

RE: Transplantation case 1 day ago

Thanks for posting this Very interesting case on the kidney transplantation community. It certainly appears that your patient recurrent episodes of...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

I would also put my money on Dents disease. The other X linked condition leading to possible nephrocalcinosis is X linked hypophosphatemia. Obvious...

View Discussion

RE: Transplantation case 1 day ago

Can you give us serial serum creatinine levels over the last year? Would be instructive ------------------------------ Satish Balan MD DM DNB Se...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

Thanks a lot prof glassock and dr shahzad. Much appreciated. ------------------------------ Hassan Abdullah MBBS Resident Nephrology Shaikh Zayed...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

I do appreciate expert reply of Prof .Glascock, Thanks a lot ------------------------------ Ahmed Yasin, MD,FASN Saudi German Hospitals Group Mad...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

X-linked inheritance and absence of a history of hypokalemia makes distal (Type 1) RTA less likely, but genetic studies should be very revealing. ...

View Discussion

RE: Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 1 day ago

PS: And yes, he is on lisinopril 40 and Farxiga 10. ------------------------------ Jeffrey Reynolds, MD, MBA Partner/Nephrologist PACT Kidney Cen...

View Discussion

RE: Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 1 day ago

Thank you so much, Dr. Glassock for the thoughtful response. Good point about the larger microtubules suggesting possible immunotactoid. The seru...

View Discussion

Transplantation case 1 day ago

31-year-old male kidney transplant recipientwith end-stage kidney disease secondary to reflux nephropathy, previously on hemodialysis since 2009, w...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

Any 24 hour urine stone profile Urine PH or ammonia With distal RTA one would expect medullary calcinosis more than cortical Distal (type 1) ren...

View Discussion

RE: Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 1 day ago

What happened to the serum levels of the Kappa IgG paraprotein with the Dara/ velcade/ steroid therapy. I assume that the patient does not have CLL...

View Discussion

Type 1 Cryo proliferative GN without identifiable clone on treatment without improvement in proteinuria 1 day ago

I would greatly appreciate your help on this case. 72 year old male (physician) in excellent health referred 2 years ago for mild proteinuria whi...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

Cortical nephrocalcinosis can occur late in conditions like Dent disease and Primary hyperoxaluria . The normal urine oxalate excretion makes Prima...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

Is cortical nephrocalcinosis classic for this? Things like cortical necrosis usually lead to cortical nephrocalcinosis. Any relevance of the locati...

View Discussion

RE: NEPHROCALCINOSIS 1 day ago

Definitely do genetic testing. This looks like X-linked disease so he may have Dent Disease, which commonly results in Nephrocalcinosis . The hypoc...

View Discussion

NEPHROCALCINOSIS 2 days ago

I have 30 year old patient with cortical nephrocalcinosis, bilateral renal stones ,creatinine 1.5 mg on potassium citrate and hydrochlorothiazide. ...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 2 days ago

Thank you Dr Pierce. Appreciate your pointing out your experience & the similarity in histopath appearance. I do recall from a good number of years...

View Discussion

Transplantation case 2 days ago

31-year-old male kidney transplant recipient with end-stage kidney disease secondary to reflux nephropathy, previously on hemodialysis since 2009, ...

View Discussion

Transplant 2 days ago

The Open Forum is a great place to post cases, but I would ask in the future please post transplant related cases on the Kidney Transplantation com...

View Discussion

RE: Transplant Case- can recurrent Ig A in transplant patient present without proteinuria and midly low C3 and more significant lower C4. 2 days ago

Please try to post transplant related cases on our Kidney Transplatation community - thanks ------------------------------ [Mark] [Lerman] [MD,...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 2 days ago

I had a case many years ago, before a lot was known about treatment, except steroids. The biopsy reminded me of T cell mediated rejection of a tran...

View Discussion

RE: treatment of C3GN after developing meningococcal infection with iptacopan 2 days ago

Thank you so much Dr. Glassock. The problem is that her meningococcal serotyping was non-typable, which indicates that it is a strain beyond the on...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 2 days ago

@Mario Rubin: No personal experience. Blocking IL-5 axis has been used only for eosinophil-rich AIN. ------------------------------ K.K. Venkat M...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 2 days ago

The group at MD Anderson in Houston has pioneered the use of infliximab (as stated in several posts) and it's benefits in the management of steroid...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 3 days ago

Another recent approach to steroid-refractory, eosinophil-rich AIN caused by ICIs is blocking the IL-5 axis. Eosinophil activation depends on the I...

View Discussion

RE: Case of intermittent Hyokalaemia with preserved kidney function 3 days ago

Serum sodium 143-145 and serum K less than 3 suggest primary hyperaldosteronism Before calling this white-coat hypertension, I would like to kno...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 3 days ago

Hi, I am current Onco-Nephrology fellow at MD Anderson we see a lot of similar cases. We give them infliximab. I also attached the recent stu...

View Discussion

RE: Refractory ICI-Associated Nephritis with Progressive AKI, Eosinophilia, and Rash After Nephrectomy – Looking for Management Suggestions 3 days ago

Murad: I attach another article on use of Infliximab, as well ------------------------------ Prem Chandran MD Adj Clinical Professor, Univ o...

View Discussion

RE: Case of intermittent Hyokalaemia with preserved kidney function 3 days ago

She does have high U K/Cr and FE K suggesting renal K loss. No evidence of primary aldosteronism or Barters or Gittelman. With this BMI could she...

View Discussion