RE: Interpretation Of Mainritsan 2 8 minutes ago

I 100% agree with Dr. Rodby that the MAINRITSAN -II trial was underpowered to examine AE occurring with the the regimens . The trial was powered fo...

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RE: diagnosis? 14 minutes ago

Thanks- Dr. Rodby- Do you have an opinion as to whether this case is an acquired form or a congenital form of Bartter Syndrome. Hopefully, the gene...

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RE: diagnosis? 36 minutes ago

"To all- does a normal serum Magnesium favor a diagnisis of Dent Disease or acquired non-genetic Bartter syndrome. ?" I say no, hypoMg is much mo...

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RE: Interpretation Of Mainritsan 2 42 minutes ago

"There is a difference between relapse in fixed regime dosing vs tailored infusion regime . Could colleague explain why they say" The only way th...

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RE: Interpretation Of Mainritsan 2 3 hours ago

The Adverse events were numerically higher in the fixed dose arm combated to the tailored dose arm but tgus difference was not stistically signific...

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RE: diagnosis? 3 hours ago

CT chest is due on Monday Yahoo Mail: Search, organise, conquer

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RE: IgA Nephropathy 3 hours ago

Possible, but not glomerular hypertrophy not seen in kidney biopsy. Hard to prove without knowing nephron #..I don't disagree with early therapy, b...

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RE: Newly Diagnosed Anca Vascultis 3 hours ago

Yes. RF = Rheumatoid Factor. ANA= antinuclear antibody ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 -...

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RE: diagnosis? 3 hours ago

These findings indicate an inappropriate increase in 1-hydroxlase Vitamin D activity- seen in Bartter syndrome and in Sarcoidosis. Have you done a ...

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RE: diagnosis? 3 hours ago

The serum calcium is normal because of secondary hyperparathyroidism!!! ------------------------------ Richard Glassock MD, FASN Laguna Woods CA...

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RE: diagnosis? 3 hours ago

If this is Bartter syndrome, then NSAID are indicated with careful monitoring. ------------------------------ Richard Glassock MD, FASN Laguna W...

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RE: diagnosis? 3 hours ago

To all- does a normal serum Magnesium favor a diagnisis of Dent Disease or acquired non-genetic Bartter syndrome. ? ---------------------------...

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RE: diagnosis? 3 hours ago

Is this a spot or 24 hour. He is polyuria so spot values will be liw- I assume that this is in mmol. ------------------------------ Richard Glass...

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RE: diagnosis? 4 hours ago

His repeat labs today showed low 25oh VIT d only 8.9 and 1-25oh VIT d was high 1 week back,,, Why? Yahoo Mail: Search, organise, conquer

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RE: diagnosis? 4 hours ago

The thread mention that elevated PTH is due to Hypercalicuria . However the patients serum calcium is normal .... Would that still cause Hyper- PTH...

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RE: Newly Diagnosed Anca Vascultis 5 hours ago

Thanks prof glassock You mean Ana + ve with RF Positivity and low complement ? --------------------------------- Muhammad Soobadar MBChB UK ---...

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RE: IgA Nephropathy 5 hours ago

Hi thanks . EGFR being preserved in my humble opinion could be due to normal glomeruli hypertrophy. I would rather act earlier than wait for drop i...

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RE: Newly Diagnosed Anca Vascultis 6 hours ago

In newly diagnosed ANCA vasculitis a high resolution Chest CT strongly recommended even in asymptomatic patients as findings can influence prognosi...

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RE: diagnosis? 6 hours ago

He is on amiloride , and thiazide . Can body share experience of using prostaglandins? Dosing ? Name ? Yahoo Mail: Search, organise, conquer

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RE: diagnosis? 6 hours ago

Serum magnesium is normal Yahoo Mail: Search, organise, conquer

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RE: diagnosis? 6 hours ago

Thanks- since adult height is an 80% inherited characteristic, the comparator should be mean adult height of parents or male siblings .just an opin...

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RE: diagnosis? 7 hours ago

For the medical historians, here are the original Dent and Bartter articles from the early 1960s. ------------------------------ John Schwartz MD...

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RE: IgA Nephropathy 8 hours ago

The 4 criteria to immediately start IS therapy 1. Low for age eGFR 2. Hematuria or hemoglobinuria 3. uPCR > 1gram with maximally tolerated ARB 4. ...

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RE: IgA Nephropathy 9 hours ago

Thanks dr hormaz What are the 4 criteria for Is? And how many you need to IS? I will read up todate as per Prof glassock when I get back home. I ...

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RE: IgA Nephropathy 9 hours ago

I have to agree with Dr. Glassock, with M1 lesion only , no hematuria , normal for age and stable eGFR , and proteinuria of > 1 gram/g , this patie...

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RE: diagnosis? 11 hours ago

What is serum magnesium level https://pubmed.ncbi.nlm.nih.gov/24321194/ --------------------------------- Dr. Hormaz Dastoor. MD, MSc, FASN Divis...

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RE: IgA Nephropathy 12 hours ago

I would think so too dr wael Would have to stop MRA too if we are starting Sparsentan I think Many thanks --------------------------------- ...

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RE: IgA Nephropathy 12 hours ago

but our target is to have proteinuria below 1 gm per day which is not achievable with max. tolerated antiproteinuric therapy . ------------------...

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RE: IgA Nephropathy 12 hours ago

Thanks prof glassock I was not aware that we used MEST C scoring for treatment ( as in the scoring able us to predict what treatment regime we giv...

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RE: diagnosis? 12 hours ago

Spot urine chloride is 23 Height is very normal as per Pakistani population. Yahoo Mail: Search, organise, conquer

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RE: Serum Ig A Level In Ig A Nephropathy / Vasculitis 13 hours ago

Gd-IgA and Gd-IgA-IgG immunocomplexes might be more reliable in reflecting disease activity (hematuria and proteinuria) and prognosis of the diseas...

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RE: Serum Ig A Level In Ig A Nephropathy / Vasculitis 13 hours ago

Maybe yes, but no FDA approved commercial test available- also questions exist on Sensitivity and Specificity . ------------------------------ Ri...

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RE: IgA Nephropathy 13 hours ago

Steroids are not indicated with an M1 lesion only. No hematuria and stable eGFR despite proteinuria above 1Gm/D- see UpToDate Chapter on treatment ...

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RE: Interpretation Of Mainritsan 2 14 hours ago

Thanks prof glassock Statistically similar but higher adverse rates in fixed dose ? Can you explain please? Do you think this Covid infection w...

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RE: IgA Nephropathy 14 hours ago

Hi my humble opinion I would stop arb and start Sparsentan I would also start tarpeyo for a start Check meds compliance I would also ask About...

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RE: Serum Ig A Level In Ig A Nephropathy / Vasculitis 17 hours ago

Perhaps in the future measuring abnormal Gd- IgA will help in diagnosis and response to therapy --------------------------------- Dr. Hormaz Dasto...

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RE: Interpretation Of Mainritsan 2 17 hours ago

The SAE rate was statistically similar but numerically higher in the Fixed dose group in thecMAINRITSAN-II trial But RTX maintenance therapy in ANC...

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RE: Interpretation Of Mainritsan 2 17 hours ago

I think practice patterns vary worldwide . Some 1. Give Rituximab 6 monthly like clockwork 2. Rituximab , dictated by CD 19 counts and use it when...

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RE: Serum Ig A Level In Ig A Nephropathy / Vasculitis 18 hours ago

Some studies from Japan have shown that an in increase in the serum IgA/C3 levels compared to normal healthy subjects has diagnostic utikity for Ig...

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Serum Ig A Level In Ig A Nephropathy / Vasculitis 18 hours ago

Dear colleagues, Do colleagues use serum ig a level as possibility for ig a neuropathy or ig a Vascultis prior to biopsy result Many thanks

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RE: Interpretation Of Mainritsan 2 18 hours ago

Thanks prof glassock always helpful as usual . Appreciate it . What about serious adverse effects ? ( question 2 ) would appreciate your input ? ...

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Newly Diagnosed Anca Vascultis 19 hours ago

If patient has new diagnosis of Anca and lethargy ans no other extra renal symptoms would colleagues routinely request CT scan ? I guess if has E...

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RE: Conventional treatment resistant Anti GBM disease 20 hours ago

Just an after thought . It is often overlooked that, unlike most forms of GN, anti-GBM disease is a "one -shot " affair in which the majority of gl...

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RE: Conventional treatment resistant Anti GBM disease 21 hours ago

Dr. Venkat. Thanks very much for your cogent responses and for the reference citations . Only case #2 in the report from the MGH has "pure" anti-GB...

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RE: IgA Nephropathy 22 hours ago

IgAN is a relapsing and remitting, life-long disease for which there is no cure (at present ). ET-1 antagonism has some anti-inflammatory , anti-fi...

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RE: anti gbm/mpo +ve in young female 22 hours ago

It is ki reports published on feb12 not in kiB Sent from my iPhoneSpelling mistakes are regretted which are not intentional

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RE: anti gbm/mpo +ve in young female 22 hours ago

I found the article in glomerular diseases but not in KI. I think that I need exact reference or author's name. ------------------------------ ...

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RE: anti gbm/mpo +ve in young female 23 hours ago

Also see paper in ki report published on line feb 12,2026 Out come in children and adults in anti gbm disease --------------------------------- Ba...

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RE: anti gbm/mpo +ve in young female 23 hours ago

Glomeular Disease (journal)Dec2025. 5(1)doi .org/10.1159/000543339Bajinder Reen Sent from my iPhoneSpelling mistakes are regretted which are not in...

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RE: Conventional treatment resistant Anti GBM disease 23 hours ago

Please see following references: https://pubmed.ncbi.nlm.nih.gov/40469278/ https://www.sciencedirect.com/science/article/pii/S246802492101295X ...

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