RE: resistant c3gn 2 hours ago

Dr. Dastoor - Pegacetocoplan is approved for therapy of C3G or Primary IC-MPGN. How convinced are you that this patient has either of these disorde...

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RE: Alport -FSGS 2 hours ago

In a female with a heterozygous pathogenic or likely pathogenic mutation of the COLIV alpha 5 gene and a clinical picture consistent with genetic F...

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RE: Alport -FSGS 3 hours ago

In the post hoc analysis ( Yee et al CJASN, 2025) of the DUPLEX study of Sparsentan vs Irbesartan in Alport related FSGS - an antiproteinuric effec...

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RE: Alport -FSGS 3 hours ago

Due to random inactivation of the X chromosome, Females with a pathogenic mutation have a mosaic pattern of tissue injury - thus the lack of GBM pa...

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RE: Leukopenia on Hemodialysis 3 hours ago

I thought ( as you mentioned) that that was a thing of the past seems in the older less biocompatible membranes: "The goal of these prospective s...

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RE: Alport -FSGS 3 hours ago

She has X linked Alports, her brother mist certainly have ESRD from it too. In the absence of biopsy findings of Alport disease , can we attribut...

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RE: resistant c3gn 3 hours ago

Pegcetacoplan may be a good idea. there is clearly activation of both classical and Regarding the c5 variant of unknown significance. obviously ...

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RE: resistant c3gn 4 hours ago

I am not sure if i would label this as C3G , but rather with a full house pattern i would classify this as IC - MPGN - though both are considered a...

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Alport -FSGS 4 hours ago

i have a 45 year old female with hx of mild HTN , since her 4th and final pregnancy in 2010 Since then she has had a slow decline in her renal fu...

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RE: resistant c3gn 5 hours ago

Dr. Gharib - you bring up an excellent and important event. The lack of LC monotypism in the frozen IF makes classical PGNMID unlihely. The issue...

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RE: resistant c3gn 6 hours ago

Hello David It's a very interesting case. What catches my attention the most and what I would focus on in this case is the reported genetic alte...

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Leukopenia on Hemodialysis 7 hours ago

Hello, I had a question regarding Leukopenia and HD patients. Looking at older articles from the late 1970s and 1980s, I found many refe...

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RE: resistant c3gn 7 hours ago

Dr. Glassoc - We can not lump all histological and serological data in one diagnosis, so i tried to make the most probable diagnosis Cryoglobuli...

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RE: Pd Question. 10 hours ago

For sure recommence the PD (assuming nothing too sinister on the ECG) and assuming volume status isn't an issue, maybe 1.5% / 1.36% q 2 hours and m...

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RE: resistant c3gn 11 hours ago

Dr. Charytan Thanks .. The new infirmation heightens my suspicion of anunderlying PGNMID or a "concealed " monotypic IC- MPGN or MN. I do not think...

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RE: resistant c3gn 12 hours ago

Nothing in post . ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA Laguna Woods CA (...

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RE: resistant c3gn 12 hours ago

Nothing in post. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Medicine at UCLA Laguna Woods CA (...

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RE: resistant c3gn 14 hours ago

------------------------------ Mohamed Gharib MBBS Ain shams university Cairo 01000322177 ------------------------------

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RE: resistant c3gn 14 hours ago

------------------------------ Mohamed Gharib MBBS Ain shams university Cairo 01000322177 ------------------------------

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RE: Pd Question. 21 hours ago

When I was young,many a moon ago we had 7% dextrose PD fluids they really removed volume as long as blood sugar did not shoot up. Anyone still uses...

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RE: Pd Question. 1 day ago

Thanks prof bargman I written name of paper you published( highly educational ) The scenario described above was encountered by myself and despite...

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RE: resistant c3gn 1 day ago

Dr. Gharib - With respect to a "diagnosis" of C3GN, what do make of the reported Fibrillary nature of the deposits (and negative DNAJB9 testing )...

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RE: resistant c3gn 1 day ago

no kappa restriction Frozen tissues consists of up to 4 glomeruli, 1 of which is globally sclerotic. FITC antisera for IgG, IgA, IgM, C3, C1q, ka...

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RE: resistant c3gn 1 day ago

Tough case. You did not give data about light chain staining in the most recent biopsy. Is there kappa restriction. Is there possibility to orde...

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RE: resistant c3gn 1 day ago

IgG subclass and SAP staining, in addition to Pronase digestion and LC staining are definitely indicated . I favor a diagnosis of "concealed " mono...

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RE: resistant c3gn 1 day ago

IgG subclass staining by IF might help. ------------------------------ Emilio Venturelli MD Scuola di specializzazione in Nefrologia, Università...

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RE: resistant c3gn 1 day ago

the igg-kappa is only detectable on IFE-spep varies from normal to slight restriction. KL ratio was 1.05 with normal levels of K and L in 2024. JB9...

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RE: resistant c3gn 1 day ago

Very puzzling case. At this age a PGNMID would be unusual but this is not typical C3GN especially with organized deposits. I am not surprised by th...

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Deadline Extension: ASN Loan Mitigation Program 1 day ago

Greetings everyone, The application deadline for the ASN Loan Mitigation Program has been extended to Wednesday, August 26. This program wi...

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Deadline Extension: ASN Loan Mitigation Program 1 day ago

Greetings everyone, The application deadline for the ASN Loan Mitigation Program has been extended to Wednesday, August 26. This program wi...

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resistant c3gn 1 day ago

Wondering what folks would do with this atypical probable c3GN patient with resistant disease 23 yo female with long history of hematuria and pro...

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Last Week to Apply to Participate in the ASN FIT Bowl at Kidney Week 2026 1 day ago

Hi All, The deadline to apply for the 2026 FIT Bowl is Friday, August 28, 2026, details below. Join the American Society of Nephrology (ASN) Fel...

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RE: Pd Question. 1 day ago

Care of the hospitalised patient receiving peritoneal dialysis: Your questions answered Rehab B Albakr https://orcid.org/0000-0002-8760-5728 and Jo...

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RE: ICI induced IgAV 1 day ago

I would not use CYC in this case. I prefer RTX based on observational studies. No RCT ------------------------------ Richard Glassock MD, FASN Em...

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RE: ICI induced IgAV 1 day ago

Thanks Dr Rodby, I've waited a week his creatinine now slighty up to 290 from 258 umol/l. Would you consider adding anything now or would you wait ...

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RE: ICI induced IgAV 1 day ago

Thank you Dr Glassock. I am hesitant on giving rituximab as I'm a bit worried if he develops a reaction he has limited lung reserve (post partial l...

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RE: Pd Question. 2 days ago

Dear Colleagues I totally agree with Dr Bargman and I think to continue with high concentrate solutions for short time mostly get good results e...

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RE: Pd Question. 2 days ago

I can't open the attachment that you sent, but I suspect it is by Chan et al about PD in the ICU "Can PD Take the Pressure?". Many (I'm being diplo...

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RE: anti gbm serology postive with fever and raised inflammatory markers 2 days ago

Thanks . Dr Saja --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: Pd Question 3 days ago

Removing the external cuff is, in general, of some help i. Curing the exit-site infection; however Pseudomonas infection are very difficult to be c...

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RE: Pd Question 3 days ago

No did not remove it. Is it something that needs to be done ? --------------------------------- Muhammad Soobadar MBChB UK ---------------------...

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RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

I want to share this update on the management of Anti-GBM; still, we are limited by evidence, and all depends on how early the diagnosis and interv...

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RE: Pd Question 3 days ago

Did you remove the external catheter cuff? ------------------------------ Giovanni Cancarini Nephrologist Brescia, Italy gcancarini@alice.it ----...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

Professor Richard, I agree that we should repeat the biopsy and then decide on the further plan accordingly, especially given the absence of c...

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Pd Question. 3 days ago

https://journals.sagepub.com/doi/10.1177/08968608221125714?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#core-bibr44-...

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RE: Pd Question 3 days ago

https://pmc.ncbi.nlm.nih.gov/articles/PMC4655795/ --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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Pd Question 3 days ago

Dear colleagues , How long to treat pseudomonas exit site infection in pd patient on APD ? I have a patient who pseudomonas ESI resistant to Cipr...

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RE: Pd Question. 3 days ago

Very helpful Paper prof bargman Any colleagues have info/ resource on mesh repair and pd dialysis whether needs holding or not ? Thanks --------...

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RE: Pd Question. 3 days ago

Many thanks prof bargman and prof rodby Case 1 Patient was given 48 hr break post pancreatic biopsy . Drain was bloody but settled down day aft...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

I have a few questions. This patient has had only one kidney biopsy 8 +years ago showing Class III LN. The Anti-DNA has been negative for oast 8 mo...

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