RE: Hyponatremia 1 hour ago

I think the VBG rules out pseudohypoNatremia this is not Hyperosmolar hyponatremia (glucose and mannitol) i doubt this is possible but dod you ...

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RE: C3G- pre and post Pegcetacoplan 2 hours ago

Dr. Dastoor- thanks for this post. A careful reading of the NEJM paper of Pegcetacoplan in C3GN (Fakhouri F, et al 2025) discloses that this kind o...

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C3G- pre and post Pegcetacoplan 6 hours ago

This is a case of a 19 year old boy from India . He was found to have sudden onset of proteinuria around 18 months ago His serologocal workup , i...

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Hyponatremia 6 hours ago

57 year old lady admitted with Right sided heart failure , Pul Htn, hx of CAD , ascites and CKD with baseline creatinine of around 2 mg /dl She w...

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RE: case of IG A Nephropathy 8 hours ago

In my opinion , the IgA deposits seen in many healthy living donors (typically without IgG or C3 deposits) should not be regarded as "igANephropath...

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RE: case of IG A Nephropathy 8 hours ago

Maybe- but if IgG and C3 are absent it looks more like the pattern seen in healthy living transplant donors . Could be just aggregated gdIgA withou...

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RE: NBLU 2026 9 hours ago

Thanks Dr. Aliano. The ASN is supporting NBLU again this year with travel support for attendees. Fellows receive $350 in travel support, though ...

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RE: case of IG A Nephropathy 9 hours ago

Immunofluorescence: kappa 1+. lamdba 2+; EM: sparse mesangial electron dense deposit Dr. Glassock: I realize that the lambda > kappa IgA and mesa...

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RE: case of IG A Nephropathy 13 hours ago

Addendum- as Dr. Venkat suggests it would be very important to know the biopsy findings of the earlier episode of Vasculitis- did it show an IgA va...

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RE: Collapsing Glomerulopathy in a Kidney Transplant Recipient 13 hours ago

dr. Venkat. Thanks for the follow up on your very informative case of Collapsing Nephropathy in a kidney transplant., --------------------------...

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RE: case of IG A Nephropathy 13 hours ago

I fundamentally agree with Dr.Venkat that yhis pstidnt is manifesting the adverse effects of maladaptive glomerular capillary hypertension stemming...

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RE: case of IG A Nephropathy 16 hours ago

Glomeruomegaly, normal SAlb level and mild podocyte effacement: suggest secondary FSGS caused by scarring/nephron loss/hyperfiltration from healing...

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NBLU 2026 17 hours ago

Hi everyone, Wanted to share an informational flyer about the NBLU (Nephrology Business Leadership University) conference which is happening late...

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RE: case of IG A Nephropathy 18 hours ago

Was C3 and IgG negative on IF. If so this might be incidental lanthanic IgA deposition and the proteinuria is the resukt of maladaption from the pr...

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RE: case of IG A Nephropathy 18 hours ago

additional record hx of depression hx of goitre meds lisinopril 40 mg daily spironolactone 25 mg bid amlodipine 10 mg daily for htn most tecen...

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case of IG A Nephropathy 20 hours ago

Dear faculty I would appreciate your input regarding my patient with iG a nephropathy 29 year old white woman had ANCA GN , GPA diagnosed at age...

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RE: FSGS conundrum 20 hours ago

Good Points Dr Raducu.- Pateints as you describe are exceptional but they exist and are not detected by therapeutic trials of potentially effecti...

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RE: Collapsing Glomerulopathy in a Kidney Transplant Recipient 21 hours ago

Further update on this patient: In my last update (posted 1.10.26), I had reported that this patient (recipient of a DCD deceased donor kidney tran...

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RE: FSGS conundrum 23 hours ago

how long to wait until we can call that Rituximab does not work and we need to try something different ? I personally had 2 cases with primary FS...

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RE: Cystatin eGFR/Cr. eGFR =0.39 1 day ago

As a biomarker of risk for CVD and other adverse events "eGFR -Cystatin C " may be superior to "eGFR-creatinine" but this advantage more likely tha...

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RE: Cystatin eGFR/Cr. eGFR =0.39 1 day ago

Thank you, got it ------------------------------ Prem Chandran MD Adj Clinical Professor, Univ of Iowa Associates In Kidney Care, PLC Des Moines ...

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RE: Cystatin eGFR/Cr. eGFR =0.39 1 day ago

Let me try again.. ------------------------------ Bhupinder Singh MD, FASN Chief Medical Officer Paradise Valley AZ -----------------------------...

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RE: Cystatin eGFR/Cr. eGFR =0.39 1 day ago

Dr Singh: I am missing the attached reference you alluded to from Leslie Inker. Thanks.... ------------------------------ Prem Chandran MD Adj Cl...

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RE: Membranous Nephropathy with Rapid Progression 1 day ago

How long has he been dialysis-dependent with stable urine output of ~ 1.0 L/day and pre-dialysis SCr levels now? Obviously, longer this period: ...

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RE: Membranous Nephropathy with Rapid Progression 1 day ago

Not much clinical suggestion of that. Patient has improved with anti biotics and diuresis. Albeit renal recovery has not yet occurred, and remains ...

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RE: renal limited microangiopathy 1 day ago

The normal serum C3 levels make anti-Factor H antibody Disease less likely but does not rule out this diagnosis, but the normal serum AP activity m...

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RE: renal limited microangiopathy 1 day ago

Did they report factor H antibody --------------------------------- Shahzad Safdar MD Mt. Auburn Nephrology, Inc. Cincinnati OH (513) 841-0222...

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RE: Cystatin eGFR/Cr. eGFR =0.39 1 day ago

Interesting novel data. This kind of eGFR approach may eventually find a niche in clinical trials or practice. For the time being , I prefer a meas...

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RE: Cystatin eGFR/Cr. eGFR =0.39 2 days ago

Thank you all for an interesting discussion and I hope that the referenced patient is doing well. We recently initiated a clinical trial in CKD/met...

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RE: renal limited microangiopathy 2 days ago

No they do not-in my opinion. The C-activation may be occurring only at tissue sites or only intermittently The laboratory features asses C activat...

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RE: Cystatin eGFR/Cr. eGFR =0.39 2 days ago

Just curious, from what is known about this patient , other than weight loss, would anyone start RASi , with or without SGLT2i, a MRA, hypouricemic...

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RE: Cystatin eGFR/Cr. eGFR =0.39 2 days ago

Cystatin-C has more problems than creatinine. It is inducible gene and the bulk of the tissue producing it vary. Drugs and disease process can affe...

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RE: renal limited microangiopathy 3 days ago

yes, I have ordered the genetic panel but does the complement panel rule out complement mediated aHUS ------------------------------ Swathi Pulle...

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RE: Membranous Nephropathy with Rapid Progression 3 days ago

Is there alveolar hemorrhage? ------------------------------ Ashraf El-Meanawy , MD, MS, PHD, FASN Professor of Medicine Director of Dialysis Med...

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RE: Membranous Nephropathy with Rapid Progression 3 days ago

More than half of the patients with ANCA negative crescentic GN superimposed on MN (PLA2R positive or negative ) fail to respond to immunosuppressi...

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RE: Membranous Nephropathy with Rapid Progression 3 days ago

Creatinine seems to be between 7 and 8 and he continues to have UOP Of around 1L still. Renal Doppler is normal and PLA2R is awaited. -----------...

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RE: renal limited microangiopathy 3 days ago

Thank you for sharing . Do you have the results of the complement genetic panel ? What you are sharing is complement and complement split product l...

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RE: Membranous Nephropathy with Rapid Progression 3 days ago

Dr. Abdullah: Is the daily urine volume increasing progressively from the last posted 1.0 L /day? Are pre-dialysis SCr level's trending down? ---...

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RE: Membranous Nephropathy with Rapid Progression 3 days ago

Unfortunately, that was not done. No stigmata of hemolysis with normal LDH and Bilirubin as well. Current update of the patient is that he ha...

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RE: renal limited microangiopathy 3 days ago

Update on Renal limited microangiopathy. It took quite some time for the VA to approve Ultomiris, but the patient has now received the first dos...

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RE: Cystatin eGFR/Cr. eGFR =0.39 Thursday, March 5 @ 4:49 PM

I am not sure that this patient has CKD. In the presence of thyroid disease, serum Cystatin C is a an unreliable biomarker for eGFR. Also , with ma...

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RE: Membranous Nephropathy with Rapid Progression Thursday, March 5 @ 2:49 PM

The complement deposits are interesting. Was the IgG typing done? Any stigmata of hemolysis? I think complement inhibitors might be a last-dit...

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RE: Cystatin eGFR/Cr. eGFR =0.39 Thursday, March 5 @ 2:13 PM

ESR 32 mm/Hr (elevated) CRP 0.9 mg/dl (mild elevation) Albumin 4.0 g/dl Hemoglobin 15 g/dl ferriten 134 ng/ml ( last year check) ---...

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RE: Cystatin eGFR/Cr. eGFR =0.39 Thursday, March 5 @ 1:59 PM

ESR (sed. rate)? CRP level? Serum albumin? Hemoglobin and ferritin levels? Inflammation can increase custstin C level. ---------------------...

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Cystatin eGFR/Cr. eGFR =0.39 Thursday, March 5 @ 1:44 PM

60 year old male here with PMHx as below significant for hypothyroidism (TSH 2.7 Normal on L thyroxine) , HTN, undeffrintiated connective tissue di...

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RE: Management of persistent amyloidosis and nephrotic range proteinuria despite Very good partial response to BMT and prior chemo Wednesday, March 4 @ 11:24 PM

Thanks a lot Dr Leung. Really educational and grateful your time and effort in educating us in this area not very familiar to me and I would suspec...

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RE: Management of persistent amyloidosis and nephrotic range proteinuria despite Very good partial response to BMT and prior chemo Wednesday, March 4 @ 8:19 PM

-if you use SAP baseline and monitoring of disease and how often? I don't because it is not available to me in the U.S. None of the AL response cri...

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RE: Membranous Nephropathy with Rapid Progression Wednesday, March 4 @ 9:31 AM

Dr. Soodabar, a positive circulating anti PLA2R antibody is not an absolute contraindication to kidney transplantation Although this patients are a...

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RE: Membranous Nephropathy with Rapid Progression Tuesday, March 3 @ 3:01 PM

Dr. Soobadar- thanks for your comments on the Vargas-Brochero et al paper in KI Reports A few points of clarification concerning this seminal an...

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RE: Membranous Nephropathy with Rapid Progression Tuesday, March 3 @ 7:54 AM

ANA and Antidsdna is negative with C3 and C4 normal as well. ------------------------------ Hassan Abdullah MBBS Resident Nephrology Shaikh Zayed...

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