Basic/Clinical Science Session
Breakthroughs in Polycystic Kidney Disease Research
October 24, 2024 | 02:00 PM - 04:00 PM
Location: Ballroom 20D, Convention Center
Session Description
PKD research has come a long way in the 30 years since the discovery of polycystins. This session presents exciting breakthroughs in the field, including a newly defined role for the autosomal recessive PKD protein fibrocystin, an approach for modeling PKD variants by assessing functional expression of the polycystin channel complex, learning about polycystin-1 auto-activation and potential ways to achieve this therapeutically with synthetic peptides, and the discovery of a novel downstream effector of polycystin signaling that could be a therapeutic target.
Learning Objective(s)
- Summarize research advances in understanding the role of the autosomal recessive PKD protein encoded by the PKHD1 gene
- Outline research assessing polycystin channel function and assessment of variants in the PKHD1 gene
- Describe polycystin-1 as an atypical G protein-coupled receptor and its potential for therapeutic activation
- Discuss the novel implication of a downstream effector of polycystin function
Learning Pathway(s)
- Genetic Diseases and Development
Moderators
Presentations
- Fibrocystin and the PKHD1 Gene: Fragments and Functions
02:00 PM - 02:30 PM
- Visual Models to Characterize Mutations and Functions of the Polycystin Complex
02:30 PM - 03:00 PM
- Activation of Polycystin 1 as a G Protein-Coupled Receptor: Tethered Agonist and Synthetic Peptides
03:00 PM - 03:30 PM
- Downstream of Polycystin Loss in ADPKD: A Newly Defined Effector
03:30 PM - 04:00 PM