Basic/Clinical Science Session
Beyond Antibody-Mediated Rejection: The Innate Immune System in Clinical Transplant Rejection, Including the Barbara T. Murphy, MB BAO BCh, Endowed Lectureship
October 26, 2024 | 10:30 AM - 12:30 PM
Location: Ballroom 20B/C, Convention Center
Session Description
Emerging data provide compelling evidence that innate immune cells (monocytes, macrophages, and NK cells) have an important role in transplant rejection and may be the defining feature of certain forms of rejection in humans. This session reviews innate immune mechanisms of rejection and summarizes new human data suggesting that kidney allograft pathologies assumed to be antibody-mediated rejection could have resulted from an innate immune cell attack. Opportunities for selective targeting of the innate immune cells to prevent or treat rejection are discussed.
ASN gratefully acknowledges Verici Dx, Renalytix, and the American Society of Transplantation for supporting the Murphy Endowed Lectureship.
Learning Objective(s)
- Identify which innate immune cells contribute to acute and chronic kidney transplant rejection
- Describe new pathological features in human kidney transplant biopsies that fall outside antibody-mediated rejection and T cell-mediated rejection
- Discuss novel targets that can be selectively targeted to dampen the innate response to allografts
Learning Pathway(s)
- Kidney Transplantation
Moderators
Presentations
- Innate Immune Cells in Transplant Rejection: What We Know
10:30 AM - 11:00 AM
- Molecular Profiling of Kidney Allograft Biopsy: The Long Shadow of Innate Immune Receptors and Cells
11:00 AM - 11:30 AM
- Microvascular Inflammation without Donor-Specific Antibodies: Is It Antibody-Mediated Rejection or Something Else?
11:30 AM - 12:00 PM
- Selective Targeting of the Innate Immune System in Transplantation: The Time Is Now: The Barbara T. Murphy, MB BAO BCh, Endowed Lectureship
12:00 PM - 12:30 PM