Kidney Week

Abstract: TH-PO1171

Can Exogenous Ketones Prevent the Effects of High Salt on Renal Vascular Resistance during Sympathoexcitation?

Session Information

• Late-Breaking Science Posters
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1601 Hypertension and CVD: Basic

Authors

• Jeong, Soolim, Indiana University Bloomington, Bloomington, Indiana, United States

Soolim Jeong, MS

• Stute, Nina Lawrene, Auburn University, Auburn, Alabama, United States

Nina Lawrene Stute, MS

• Sanchez, Sofia O, Indiana University Bloomington, Bloomington, Indiana, United States

Sofia O Sanchez, PhD, RD, MBA

• Gutierrez, Orlando M., The University of Alabama at Birmingham, Birmingham, Alabama, United States

Orlando M. Gutierrez, MD

• Schlader, Zachary, Indiana University Bloomington, Bloomington, Indiana, United States

Zachary Schlader, MS, PhD

• Robinson, Austin, Indiana University Bloomington, Bloomington, Indiana, United States

Austin Robinson, PhD

Background

Renal vascular resistance (RVR) is the opposition to blood flow by renal arteries. At the population level, dietary salt increases RVR and subsequently blood pressure (BP), which is associated with cardiovascular disease risk. However, recent data indicate exogenous ketones may offset adverse cardiorenal effects of salt. Therefore, we investigated whether dietary ketone and salt supplementation influences RVR and BP during sympathoexcitation (cold pressor test).

Methods

Thirteen participants were included in this analysis (10 M/3 F, age 30 ± 9 years. BMI: 26 ± 3 kg/m²; mean ± SD). In this registered clinical trial (NCT05545501) participants were randomized to three 10-day conditions: A) control; B) high salt; C) high salt and ketone supplementation. Renal blood velocity (RBV) in the renal artery was measured in the decubitus position using Doppler ultrasound during a 3-minute baseline, 3-minute cold pressor test, and 2-minute recovery. We measured brachial BP with a validated oscillometric BP monitor. We calculated RVR as mean BP divided by RBV. We also calculated renal vascular conductance (RVC), the ease of blood flow through the renal arteries, as RBV divided by mean BP. Statistical analyses included ANOVA with α set at ≤ 0.05.

Results

Baseline BP did not differ between conditions for systolic (control: 107 ± 10, salt: 109 ± 14, ketone and salt: 107 ± 8 mmHg, p=0.91) or diastolic BP (control: 64 ± 6, salt: 63 ± 7, ketone and salt: 64 ± 5, p=0.90). Further, there were no differences for baseline RVR (control: 1.9 ± 0.6, salt: 2.1 ± 1.0, ketone and salt: 2.0 ± 0.8 mmHg/cm/s, p=0.86) or RVC (control: 0.6 ± 0.2, salt: 0.6 ± 0.2, ketone and salt: 0.6 ± 0.2 cm/s/mmHg, p=0.99). There were no effects of diet during CPT and REC for delta MAP (p=0.99), RVR (p=0.89), or RVC (p=0.58).

Conclusion

We observed no changes in blood pressure, renal vascular resistance, or renal vascular conductance between the three diets in our preliminary dataset; however, additional data is needed.

Funding

• Other NIH Support