Kidney Week

Abstract: INFO09-TH

Harnessing Basic, Clinical, and Translational Research to Advance Kidney Health Equity: The Johns Hopkins O'Brien Center

Session Information

• Informational Posters - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• No subcategory defined

Authors

• Crews, Deidra C., Johns Hopkins University, Baltimore, Maryland, United States

Deidra C. Crews, MD, ScM, FASN

• Welling, Paul A., Johns Hopkins University, Baltimore, Maryland, United States

Paul A. Welling, MD

• Pluznick, Jennifer L., Johns Hopkins University, Baltimore, Maryland, United States

Jennifer L. Pluznick, PhD

• Appel, Lawrence J., Johns Hopkins University, Baltimore, Maryland, United States

Lawrence J. Appel, MD, MPH

• Rebholz, Casey, Johns Hopkins University, Baltimore, Maryland, United States

Casey Rebholz, MS, PhD, MPH

• Coresh, Josef, New York University, New York, New York, United States

Josef Coresh, MD, PhD, FASN

• Parikh, Chirag R., Johns Hopkins University, Baltimore, Maryland, United States

Chirag R. Parikh, MD, PhD, FASN

Group or Team Name

• Johns Hopkins O'Brien Center to Advance Kidney Health Equity.

Description

The Johns Hopkins (JH) O’Brien Center to Advance Kidney Health Equity is harnessing collective expertise of basic, clinical and translational researchers at JH to serve as a national resource for investigators addressing the fundamental question of: what are underlying mechanisms responsible for profound disparities in kidney health and how can they be mitigated?

The resources and services available from the JH O’Brien Center support this overarching goal and include:

Clinical Science Dietary and Social Stressor Laboratory (C-DSSL) Services
The C-DSSL provides: 1) clinical study design; 2) dietary assessment; 3) access to numerous large cohort studies, with racially and socioeconomically diverse populations, deep phenotyping and collection of dietary data, stored biospecimens, and long follow-up periods; 4) feeding studies modeled on the Dietary Approaches to Stop Hypertension trials; 5) behavioral intervention studies; 6) translational studies in the community; 7) use of publicly available datasets; and 8) biostatistical support.

Basic Science Dietary and Social Stressor Laboratory (B-DSSL)
The B-DSSL provides comprehensive services and resources for preclinical research to determine the mechanistic underpinnings of human health disparity stressors. Services include: 1) study design; 2) humanized mouse diet protocols; 3) comprehensive mouse kidney phenotyping for exploring stress mechanisms from whole animal physiology to molecular mechanisms; 4) lipid and carbohydrate metabolism phenotyping core; 5) a core for studying immunological manifestations of dietary and social stressors in the kidney; 6) microbiome core with germ-free facility; and 7) mouse biobank of dietary and social stress models.

A joint consultation service, and deliberate team approach melds the two laboratories, and creates an innovative bidirectional pipeline (Figure) maximizing translation.

Funding

• NIDDK