Kidney Week

Abstract: FR-PO310

Photobiomodulation in Kidney Function in Rats with Diabetic Kidney Disease

Session Information

• Diabetic Kidney Disease: Basic - 1
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Diabetic Kidney Disease

• 701 Diabetic Kidney Disease: Basic

Authors

• García, Jessica Paola, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Jessica Paola García, RN

• Silva, Eloiza Oliveira, Universidade de Sao Paulo, Sao Paulo, Brazil

Eloiza Oliveira Silva, MS, MSc

• Ferreira Vieira, Guilherme Henrique, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Guilherme Henrique Ferreira Vieira

• Victoria, Carla Djamila de Pina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Carla Djamila de Pina Victoria

• Gonçalves, Maikol L C, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Maikol L C Gonçalves, RN

• Oliveira Maia, Alessandra, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Alessandra Oliveira Maia, RN

• Silva, Juliana Veloso Gusmão, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Juliana Veloso Gusmão Silva

• Alves, Mykelly Gomes, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Mykelly Gomes Alves, MSc

• Lima, Camila, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Camila Lima, PhD, RN

• Santos, Luciana Soares Costa, Universidade de Sao Paulo, Sao Paulo, Brazil

Luciana Soares Costa Santos, RN

• Watanabe, Mirian, United Metropolitan Colleges University Center, Sao Paulo, SP, Brazil

Mirian Watanabe, PhD, RN

• Vattimo, Maria De Fatima, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Maria De Fatima Vattimo, MS, MSc, PhD, RN

Group or Team Name

• Group of Studies on Acute Kidney Injury.

Background

Diabetic kidney disease (DKD) is a serious microangiopathic complication of diabetes mellitus (DM). Photobiomodulation therapy (Pbm) is a non-pharmacological therapy based on the red spectral range. Studies with a CKD model in rats showed positive results in CKD after the application of Pbm, such as reduced blood pressure, increased glomerular filtration rate and decreased tubulointerstitial fibrosis. The aim of this study is to evaluate the impact of Pbm on the function of rats with DRD.

Methods

Wistar rats weighing 280-300 g randomized as follows: Citrate (CT): animals that received streptozotocin vehicle (citrate; iv, caudal, single dose); Diabetes Mellitus (DM): animals that received streptozotocin (STZ, 60mg/kg; iv; single dose); Diabetes Mellitus + Low-intensity laser (DM+Pbm): DM animals, in the third, were irradiated with a low-intensity infrared laser (wavelength 808nm, power 100mW, energy 3 Joule, a point on the right flank on the left, 3 times a week, 6 weeks). Renal function (serum creatinine-CrS; creatinine clearance; inulin clearance-Clin) and oxidative profile (urinary peroxides, lipid peroxidation) were evaluated.

Results

The DM group reduced renal function when evaluating serum creatinine, creatinine clearance and inulin, while the DM+Pbm group increased these parameters, attenuating the deterioration of renal function and improving the oxidative profile. The group subjected to photobiomodulation showed a reduction in oxidative stress compared to the DM group.

Conclusion

The results confirmed that photobiomodulation attenuates the reduction in renal function induced by diabetic kidney disease.