Kidney Week

Abstract: SA-PO598

Patients with Polycystic Kidney Diseases with Normal Kidney Function Report Poor Sleep Quality

Session Information

• Cystic Kidney Diseases: Genetic Causes, Modifiers, and Extrarenal Manifestations
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1201 Genetic Diseases of the Kidneys: Cystic

Authors

• Hanlon, Erin C., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States

Erin C. Hanlon, PhD

• Sintetas, Stephanie N., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States

Stephanie N. Sintetas

• Salvo, Elizabeth, University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States

Elizabeth Salvo, PhD

• Ding, Qiyi, University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States

Qiyi Ding

• Chapman, Arlene B., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States

Arlene B. Chapman, MD

Background

In general, kidney disease has been reported to be associated with poor sleep quality, sleep disturbances, and sleep disorders including obstructive sleep apnea (OSA). While these abnormalities have been reported in CKD population, little is known about sleep characteristics in patients with autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic kidney disorder worldwide. It is possible that aspects unique to ADPKD (increased kidney and liver volumes) may contribute to altered respiratory mechanics that can contribute to sleep abnormalities. These increases in organ volume occur in the setting of normal kidney function. Thus, in this pilot, we examined self-reported sleep characteristics in ADPKD patients with normal kidney function (eGFR > 90 mL/min) compared to a group of BMI, age, and sex matched healthy controls.

Methods

ADPKD and matched controls were asked to fill out gold-standard questionnaires that assess aspects of sleep quality (Pittsburgh Sleep Quality Index - PSQI) and risk for the sleep disorder OSA (Stop-Bang). Chronotype was also assessed with the Owl/Lark Questionnaire in all individuals.

Results

Seven individuals with PKD (4 women, 3 men) with a mean age of 34 years (± 9.5) and body mass index (BMI) of 30.9 kg/m² (± 9) were compared to seven matched controls (4 women, 3 men) with a mean age of 32 years (± 8) and a BMI of 34 kg/m² (± 10). Both groups reported to be morning types with similar scores on the Owl/Lark Questionnaire (PKD: 55.3 ± 11.3 vs Control: 57.5 ± 13.9) and were both at low to intermediate risk for OSA according to the STOP-Bang questionnaire (ADPKD: 1.9 ± 1.1 vs Control: 1.5 ± 0.8). Six ADPKD individuals completed the PSQI, and interestingly, when compared to their six matched controls, ADPKD subjects had significantly higher PSQI ratings than controls (ADPKD: 5.3 ± 1.8 vs Control: 3.7 ± 0.8, p = 0.019) indicating that they had poorer sleep quality.

Conclusion

These data suggest that ADPKD individuals may experience poor sleep quality when compared to healthy matched controls, that is not a product of diminished kidney function. The contributions to reduction in sleep quality in ADPKD may be multifactorial including increased abdominal girth due to liver and kidney cyst burden, chronic pain and/or the psychological impact of having a hereditary kidney disorder.