Kidney Week

Abstract: PUB406

Clinical Characteristics and Laboratory Findings in Primary vs. Secondary Membranous Nephropathy in Western Mexico

Session Information

• Publication Only

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics

Authors

• Flores Fonseca, Milagros Melissa, Instituto Mexicano del Seguro Social Delegacion Jalisco, Guadalajara, Jalisco, Mexico

Milagros Melissa Flores Fonseca, MD, MSc

• Garcia-Rivera, Alejandro, Instituto Mexicano del Seguro Social Delegacion Jalisco, Guadalajara, Jalisco, Mexico

Alejandro Garcia-Rivera, MD

• Sanchez-Vazquez, Omar Humberto, Instituto Mexicano del Seguro Social Delegacion Jalisco, Guadalajara, Jalisco, Mexico

Omar Humberto Sanchez-Vazquez, MD

• Velasco, Sandra Fabiola, Universidad de Guadalajara Centro Universitario de Ciencias Exactas e Ingenieria, Guadalajara, Jalisco, Mexico

Sandra Fabiola Velasco, PhD

• Verdugo, Samantha Isabel, Instituto Mexicano del Seguro Social Delegacion Jalisco, Guadalajara, Jalisco, Mexico

Samantha Isabel Verdugo, MD

Background

Membranous nephropathy (MN), a major cause of nephrotic syndrome in adults, occurs in primary and secondary forms. Accurate differentiation between these forms is essential for effective treatment and prognosis.

Methods

Retrospective observational, single-center study, in a third-level hospital in Western Mexico. We collected demographic, laboratory and kidney pathology data from patients biopsied and diagnosed with MN from January 2022-January 2023, and registered in the center’s Glomerular Disease Registry.

Results

Overall, 81 participants were included in the study. The mean age was 35.4 y (SD ±16.3), 41 were female (50.6%), 61 patients (75.3%) presented with nephrotic syndrome and 30 patients (37%) had AKI at presentation. Table 1 shows primary and secondary MN's clinical, laboratory, and pathology characteristics. The most common cause of secondary MN was lupus nephritis.

Conclusion

Primary MN is associated with higher degree of proteinuria and a higher prevalence of nephrotic syndrome at presentation compared to secondary MN. AKI at presentation was more common in primary MN, and serum albumin levels were lower. Only 30.3% of those classified as primary MN had positivity for PLA2r antigen on biopsy, a lower prevalence compared to other cohorts.