Kidney Week

Abstract: FR-OR92

Risk of Congenital Malformation in Newborns of Mothers with Kidney Diseases: A Retrospective Cohort Study Using National Health Insurance Service Data

Session Information

• Women's Health and Kidney Diseases: From Bench to Bedside
  October 25, 2024 | Location: Room 24, Convention Center
  Abstract Time: 04:40 PM - 04:50 PM

Category: Women's Health and Kidney Diseases

• 2200 Women's Health and Kidney Diseases

Authors

• Han, Seung hyun, Seoul National University Borame Medical Center, Seoul, Korea (the Republic of)

Seung hyun Han, MD

• Song, Jeongin, Dongguk University Ilsan Hospital, Ilsan, Korea (the Republic of)

Jeongin Song, MD

• Park, Sehoon, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Sehoon Park, MD, PhD

• Lee, Hajeong, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Hajeong Lee, MD, PhD

Background

The risk of congenital malformations in pregnancies of mothers with kidney disease, including chronic kidney disease (CKD), end-stage kidney disease (ESKD) and kidney transplant (KT) remains unclear.

Methods

A retrospective cohort study using National Health Insurance Service (NHIS) data from 2008 to 2017 was conducted in Korea, including women who delivered during this period and their newborns. The risk of congenital malformations in women with CKD, ESKD, and KT was compared with healthy controls without diabetes or hypertension. Multivariate logistic regression models were used to assess the risk of congenital malformations.

Results

A total of 2,605,422 pregnant women and their 3,637,903 children were included in the present study. Among them, 47,166 women had kidney diseases, including CKD (n = 46,930), ESKD (n = 49), and KT (n = 187). After adjusting for age, parity, hypertension, diabetes, fetal sex, smoking, BMI, preterm birth, and preeclampsia, the KT and CKD group showed a significantly increased risk of any congenital malformations (hazard ratio [HR], 1.81; 95% confidential interval [CI], 1.31-2.45; HR, 1.20; 95% CI, 1.17-1.22, respectively). The ESKD group also tended to show an increased risk of congenital malformation (HR, 1.71; p = 0.080).

Conclusion

This large-scale, population-based study indicated that neonates born to mothers with kidney diseases, especially KT and CKD, have an increased risk of congenital malformations compared to those born to healthy mothers. This highlights the need for specialized prenatal care and monitoring to improve potential fetal malformations.