Abstract: FR-PO1079
Magnesium Deficiency in a Multiethnic Asian Patient Population with CKD
Session Information
- Kidney Nutrition and Metabolism
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Teo, Boon Wee, National University of Singapore Yong Loo Lin School of Medicine, Singapore, Singapore
- Chan, Gek Cher, National University Hospital, Singapore, Singapore, Singapore
Background
Magnesium homeostasis is primarily regulated by the kidneys. Due to the poor correlation between serum magnesium (mmol/L) and total body magnesium, magnesium deficiency is difficult to diagnose in the chronic kidney disease (CKD) population. We analyzed serum magnesium concentrations, 24-hour urinary magnesium excretion (24UMg, mol), and fractional excretion of magnesium (FEMg) in a multi-ethnic Asian cohort of CKD and healthy participants to determine magnesium deficiency.
Methods
We retrieved data from 232 patients with stable CKD from the Asian Kidney Disease Study, and 103 healthy participants without diabetes, hypertension or urinary abnormalities from the Singapore Kidney Function Study. Participants had 24-hour urine collection followed by blood and spot urine sampling, and measurement of the glomerular filtration rate using Tc99m-DTPA. We analyzed using JMP14 and SPSS with standard statistical tests. Magnesium deficiency is defined as 24UMg <1.9444 and serum magnesium ≦0.75.
Results
There are 19/335 (5.67%) participants with (16/19, 84.21% have diabetes). There are 23/335 (6.87%; 17/23 had CKD) participants with serum magnesium ≦0.75. There is no difference by age (p = 0.244), gender (p =0.162), and ethnicity (p = 0.520). However, participants with serum magnesium ≦0.75 have higher body weight on average 74.74±16.5 kg versus 63.86±11.5 kg, p = 0.009. Serum magnesium is lower in CKD patients (0.86 ± 0.11 vs 0.90 ± 0.68, p <0.001), and positively correlated with declining GFR (p <0.001, r = -0.569). More CKD (89/232, 38.36%) patients compared to healthy individuals (26/103, 25.24%) have 24UMg <1.9444 (p = 0.0196). Older patients are more likely to have 24UMg <1.9444 (p = 0.0253).
Conclusion
A combination of 24-hour urine collection for magnesium and serum magnesium concentrations may identify patients at risk of magnesium deficiency, especially in diabetic and CKD patients.
Funding
- Government Support – Non-U.S.