Kidney Week

Abstract: FR-PO1058

Dietary Fiber Intake and Mental Health in a Multicenter Prospective Hemodialysis Cohort

Session Information

• Kidney Nutrition and Metabolism
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Narasaki, Yoko, University of California Los Angeles, Los Angeles, California, United States

Yoko Narasaki, MS, PhD

• You, Amy Seungsook, University of California Los Angeles, Los Angeles, California, United States

Amy Seungsook You, MS

• Torres Rivera, Silvina, University of California Los Angeles, Los Angeles, California, United States

Silvina Torres Rivera

• Nguyen, Danh V., University of California Irvine, Irvine, California, United States

Danh V. Nguyen, PhD

• Kalantar-Zadeh, Kamyar, Harbor-UCLA Medical Center, Torrance, California, United States

Kamyar Kalantar-Zadeh, MD, DrMed, PhD, MPH, FASN

• Rhee, Connie, University of California Los Angeles, Los Angeles, California, United States

Connie Rhee, MD, MS

Background

While studies in CKD patients show dietary fiber intake is associated with better health outcomes including lower incidence of CKD, risk of CV events, generation of uremic toxins and inflammatory markers, and less symptom burden (i.e., constipation), little is known about the impact of dietary fiber intake on mental health. We thus sought to examine the relationship of dietary fiber intake with depression in a prospective HD cohort.

Methods

Among 584 HD patients from the multicenter NIH MADRAD cohort recruited across 16 outpatient dialysis clinics, information regarding dietary fiber intake obtained via protocolized Food Frequency Questionnaires (FFQs) and depression severity ascertained by the Beck Depression Inventory-II (BDI-II) administered over 10/2011-9/2022. We examined associations of dietary fiber intake categorized as quartiles with likelihood of having a low (more favorable) BDI-II score (i.e., lowest quartile [Q1]) using multivariable logistic regression models.

Results

The mean±SD of age of the cohort was 54±15 years, among whom 55% were male, 33% were of Black race, and 48% were of Hispanic ethnicity. In unadjusted, case-mix, expanded case-mix, and expanded case-mix+laboratory adjusted analyses, the highest quartile (Q4) of residual dietary fiber intake was associated with higher likelihood of a lower (more favorable) BDI-II score (Ref: Q1, Table 1). In the expanded case-mix+laboratory models, compared to patients with the lowest quartile (Q1) of fiber intake, those with the highest quartile (Q4) of fiber intake had a 2.3 higher likelihood of having a more favorable BDI-II score.

Conclusion

In a well-characterized prospective HD cohort, higher dietary fiber intake was associated with lower likelihood of depression. Further studies are needed to determine the causal mechanisms underlying dietary fiber intake and mental health in this population.

Funding

• NIDDK Support