Kidney Week

Abstract: SA-PO447

Peritoneal Equilibration Test: Comparison of Different Cutoff Values

Session Information

• Home Dialysis - 2
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

• Del Toro-Cisneros, Noemi, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico

Noemi Del Toro-Cisneros, MD

• Ortega, Rosario Guadalupe Hernandez, Department of Nephrology, ISSEMyM Ecatepec, State of Mexico, State of Mexico, Mexico

Rosario Guadalupe Hernandez Ortega, PhD

• Zuñiga Gonzalez, Erick Yasar, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico

Erick Yasar Zuñiga Gonzalez, MD

• Quinonez-Flores, Alejandro, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico

Alejandro Quinonez-Flores, MD

• Fueyo, Omar, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico

Omar Fueyo, MD

• Rincon-Pedrero, Rodolfo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico

Rodolfo Rincon-Pedrero, MD

Background

The aim of this study was to compare the type of peritoneal transport using the Peritoneal Equilibration Test (PET) performed at 2 and 4 hours with the cut-off values described by Twardowski (1) and Cueto-Manzano (2) and to propose neu cut-off values for the test at 2 and 4 hours.

Methods

This was a retrospective study, we included patients on peritoneal dialysis with PET in two tertiary care centers in Mexico between 2016-2023. The type of peritoneal transport obtained from Creatinine D/P was compared at 2 hours vs. 4 hours, depending on the result it was classified as high (H), high average (HA), low average (LA) and low (L). In addition, new cut-off values are proposed using the method initially described by Twardowski (1) based on the mean and +/- standard deviation.

Results

Two hundred and two PET studies were included. Eighty-three patients (41%) were men, median age was 43 years (interquartile range 27-58 years). The main causes of chronic kidney disease (CKD) were diabetes 39% (79 patiens) and unknown cause 35% (71 patients). The median time in dialysis was 18 months. The indications for performing PET were initiation of dialysis 48% (97), failure of ultrafiltration 8% (16), after peritonitis 7% (15), and the rest for therapy adequacy. Table 1 presents the type of peritoneal transport according to the cut-off values described in the literature as well as the values proposed from this study. As can be seen, the cut-off values at 2 hours described bye Cueto-Manzano and Twardowski compared to 4 hours incorrectly classify 13 and 6% respectively as high transporters, while in the low transportes they classified 13 and 8% less patients in the category.

Conclusion

In this study we found that the cut-off values established for the PET study at 2 hours overestimate patients with high transport and underestimate those with low transport. The new proposed value appropriately classifies patients with high and low solute transport.