Abstract: FR-PO989
30 Years of Kidney Biopsy Data in Western Mexico
Session Information
- Pathology and Lab Medicine - 1
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pathology and Lab Medicine
- 1800 Pathology and Lab Medicine
Authors
- Alcantar Vallin, Maria de la Luz, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Lopez, Marisol, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Padilla Armas, Jorge Luis, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Sainz Del Real, Susana Maria De Los Angeles, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Chavez, Jonathan, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Villalvazo Maciel, Estefania, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Aranda, Andres, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Franco Garcia, Martha Karina, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Orozco, Carlos Emiliano, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Cruz Aragon, Fernando, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Navarro Blackaller, Guillermo, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
- Medina, Ramon, Hospital Civil de Guadalajara Unidad Hospitalaria Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
Background
A kidney biopsy provides the best opportunity to establish the etiology of the Chronic Kidney Disease (CKD), thereby improving management and predicting prognosis.
Methods
A retrospective study was conducted that included adult patients who underwent renal biopsy between 1990 and 2019, performed by nephrologists in 4 centers in western Mexico and analyzed by 2 nephropathologists.
Results
In the 30 years of study, 1933 kidney biopsies were studied, FSGS was the most frequent finding in 28%, followed by Lupus Nephritis. Table 1. We found predominance of lupus nephritis in women and IgAN in men.
Conclusion
In Western Mexico, FSGS is the most frequent histological findings. In the last two decades, we observed a increase in lupus nephritis, pauci-immune glomerulonephritis and tubulopathies, which could be related to changes in causal factors.
In the last decade we also observed a greater number of kidney graft biopsies, compatible with the increase in the number of kidney transplants performed. We consider that the proportion of the chronic kidney disease burden constituted by glomerulonephritis would be illuminated by dissecting it through a comprehensive epidemiological approach.
Histopathologic Diagnoses
| 1990-2000 | 2001-2010 | 2011-2019 | |
| MCD | 1 (0.9) | 6 (1.9) | 49 (4.1) |
| FSGS | 28 (25.5) | 139 (44.8) | 406 (34) |
| MN | 9 (8.2) | 42 (13.5) | 84 (7) |
| IgA/HSP | 1 (0.9) | 16 (5.2) | 104 (8.7) |
| MPGN/C3GP | 13 (11.8) | 25 (8.1) | 35 (2.9) |
| Amyloid | 3 (2.7) | 4 (1.3) | 34 (2.8) |
| Diabetic GS | 9 (8.2) | 42 (13.5) | 84 (7) |
| LN | 6 (5.5) | 38 (12.3) | 181 (15.2) |
| Pauci-immune GN | 2(1.8) | 3 (1) | 68 (5.7) |
| TMA | 0 | 1 (0.3) | 9 (0.8) |
| DDD | 0 | 0 | 1 (0.1) |
| C1q N | 0 | 1 (0.3) | 6 (0.5) |
| Nodular GS | 0 | 2 (0.6) | 6 (0.5) |
| Proliferative Mesangial GN (NOS) | 42 (38.2) | 18 (5.8) | 2 (0.2) |
| Post infectious GN | 1 (0.9) | 2 (0.6) | 7 (0.6) |
| Tubulointerstitial | 2 (1.8) | 4 (1.3) | 71 (5.9) |
| ATN | 0 | 2 (0.6) | 66 (5.5) |
| Deposition | 0 | 0 | 6 (0.5) |
| Inespecific | 0 | 0 | 5 (0.5) |