Kidney Week

Abstract: PUB540

Anti-human Leukocyte Antigen (HLA) Antibodies in Patients with ESKD on Kidney Transplantation Protocol

Session Information

• Publication Only

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Xulú Díaz, Victor Manuel, Hospital General San Juan de Dios, Guatemala, Guatemala, Guatemala

Victor Manuel Xulú Díaz, MD

• Perez, Elio, Hospital General San Juan de Dios, Guatemala, Guatemala, Guatemala

Elio Perez, MD

• Escobar Castro, Karla, Hospital General San Juan de Dios, Guatemala, Guatemala, Guatemala

Karla Escobar Castro, MSc, DrPH

• Chavez, Ada Noemi, Hospital General San Juan de Dios, Guatemala, Guatemala, Guatemala

Ada Noemi Chavez, MD

Background

Renal transplant is the chosen treatment for the ESRD (End-Stage Renal Disease), so identifying factors possibly associated with complications such as rejection helps to improve renal graft survival.

Methods

Retrospective cross-sectional observational study, 150 files were selected; sex, age, medical records, type of renal transplant protocol, record of infectious processes, as well as records of exposure to sensitization factors were reviewed.

Results

The average age of the parties was 30 years old, the youngest was 13 years old and the oldest was 75 years old; 46.7% were female and 53.3% were male. 71.3% of patients had transfusion exposure, 30% of patients had previous pregnancy exposure and 8% of the parties had a previous transplant record; 5.3% had diabetes mellitus, and 31.3% of the patients had infections. The 64% of patients were on cadaveric transplant protocols, 36% were on living-donor transplant protocols.

Conclusion

The prevalence of anti-HLA antibodies in patients with chronic renal disease undergoing renal transplant protocol at the Hospital General San Juand de Dios was found to be 33.3%. Previous transplant record was associates with anti-HLA antibodies generation in renal transplant protocol patients.