Kidney Week

Abstract: PUB186

5-Year Mortality Outcomes of High-Volume Hemodiafiltration in Mexico: Insights from Real-World Data

Session Information

• Publication Only

Category: Dialysis

• 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Gil, Salvador Lopez, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, México City, Mexico

Salvador Lopez Gil, MD

• Fuentes Mercado, Alfredo, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, México City, Mexico

Alfredo Fuentes Mercado, MD

• Jaime Borja, Erika Elizabet, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, México City, Mexico

Erika Elizabet Jaime Borja, MS

• Gomez Johnson, Victor Hugo, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, México City, Mexico

Victor Hugo Gomez Johnson, MD

• Madero, Magdalena, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, México City, Mexico

Magdalena Madero, MD

Background

High volume hemodiafiltration (HDF) offers significant benefits for patients undergoing renal replacement therapy. The objective of this study is to evaluate real world data and assess mortality between pre and post dilutional HDF modalities.

Methods

In this observational, cross-sectional, retrospective study we analyzed all prescribed sessions over a 5-year period in our HDF clinic to evaluate overall mortality rates and assess mortality differences between pre- and post-dilutional HDF modalities. The statistical analysis was made using mortality rates and Mantel-Cox test.

Results

89 patients of whom 66.3% were female were included with a total of 26,047 HDF sessions over the past five years. During the study period, outcomes included 16 deaths, 23 kidney transplants, 5 peritoneal dialysis transition, 1 loss to follow-up, and 2 cases of kidney function recovery. . The distribution of vascular access types revealed 59 tunneled catheters, 10 non-tunneled catheters, and 20 arteriovenous fistulas. Patients were further categorized based on HDF modality (table 1.) Mortality rates demonstrated no significant differences between the two HDF modalities, yielding an overall mortality rate of 0.8 per 1,000 population—0.7 for pre-dilution HDF and 0.8 for post-dilution HDF (logrank: 0.9785).

Conclusion

No mortality differences were found between pre and post dilutional OL- HDF. Larger studies are warranted to confirm our findings.