Abstract: TH-PO1083
Examining the Association between Quality of Life and Functional Status in African American Adults with CKD in Southeast Wisconsin: A Cross-Sectional Study
Session Information
- CKD: Therapeutic Advances
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Ozieh, Mukoso N., Medical College of Wisconsin Department of Medicine, Milwaukee, Wisconsin, United States
- Dawson, Aprill, Medical College of Wisconsin Department of Medicine, Milwaukee, Wisconsin, United States
- Egede, Leonard E., Medical College of Wisconsin Department of Medicine, Milwaukee, Wisconsin, United States
Background
CKD is a burdensome disease and quality of life (QOL) independently predicts morbidity and mortality in patients with CKD. The aim of this study was to examine the association between quality of life and functional status in African American adults with chronic kidney disease in southeast Wisconsin.
Methods
Three hundred African American adults were recruited from southeast Wisconsin, United States in 2020. Individuals aged 21 and older with a diagnosis of chronic kidney disease were eligible to participate. CKD diagnosis was based on self-report and laboratory diagnosis based on estimated glomerular filtration rate (eGFR) in ml/min/1.73m2 using CKD-EPI 2021. Quality of life was based on the physical component score (PCS) and mental component score (MCS) and functional status was based on the EQ-5D-3L which comprises 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression and the EQ visual analog scale (VAS) scores which range from 0 to 100, where 100 is the best possible health state. Unadjusted and adjusted models were performed using the QOL components and the five dimensions of functional status as the dependent variables adjusting for relevant covariates.
Results
In this cross-sectional study of 300 African American adults, the mean age was 51.9 ± 12.5 for CKD on dialysis (CKD-D) and 60.3 ± 11.4 non-dialysis dependent CKD (CKD-ND). Mean eGFR for CKD-D was 7.8 ± 6.7 and 50.8 ± 22.6 for CKD-ND. We found significant associations for CKD-ND status and EQ pain/discomfort (β = 0.52, p < 0.01). BMI was an independent correlate for PCS (β = 0.25, p <0.01), EQ VAS (β = -7.5, p <0.01), EQ mobility (β = 0.41, p <0.01), EQ self-care (β = 0.37, p <0.01), EQ usual activities (β = 0.35, p <0.01), and EQ anxiety/depression (β = 0.41, p <0.01). Employment was an independent correlate for EQ VAS (β = 9.69, p <0.01), EQ self-care (β = -0.48, p <0.01), EQ usual activities (β = -0.67, p <0.01), and EQ anxiety/depression (β = -0.49, p <0.01). We did not significant associations for CKD-ND status and mcs (β = -0.61, p 0.07).
Conclusion
Future studies exploring the direct and indirect pathways to understand the relationship between functional status and CKD-ND are needed in order to develop novel interventions to address and improve QOL and functional status in adults with CKD.
Funding
- NIDDK Support