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Kidney Week

Abstract: SA-PO209

Global Burden of Kidney Cancer Attributable to High Body Mass Index in 204 Countries and Territories, 1990-2021: Insights from the GBD 2021 Study

Session Information

Category: Onconephrology

  • 1700 Onconephrology

Authors

  • Shandilya, Ashwinikumar, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, India
  • Katam, Shruthi, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh, India
  • Waqas, Muhammad, Jinnah Sindh Medical University, Karachi, Sindh, Pakistan
  • Bhavanam, Sravani, Sri Devaraj Urs Medical College, Karnataka, India
  • Goel, Shrey, Government Medical College and Hospital Chandigarh, Chandigarh, Chandigarh, India
  • Syed, Saif, Royal College of Surgeons in Ireland, Dublin, Ireland
  • Lakkimsetti, Mohit, Mamata Medical College, Khammam, Telangana, India
  • Amin, Vishrant, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, Gujarat, India
  • Patel, Juhi, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, Gujarat, India
  • Desai, Hardik, Gujarat Adani Institute of Medical Science, Bhuj, Gujarat, India
Background

The burden of kidney cancer (KC) has escalated over the past three decades, alongside modifiable risk factors such as high body mass index (H-BMI). This pioneering study evaluates the burden of KC due to H-BMI over the last three decades, including the initial two years of the pandemic where non-COVID related excess mortality surged, and cancer patients faced challenges in accessing care.

Methods

Utilizing the GBD 2021 framework, we estimated the deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) due to KC attributable to H-BMI by age, sex, year, across 204 countries and territories from 1990-2021.

Results

The annual percentage change (APC) in age-standardized mortality rate (ASMR) increased by 20% (95% UI: 13-27%), with DALYs rate rising by 15% (9-22%) from 1990-2021. Regionally, the highest ASMR was observed in Southern Latin America at 1.18 per 100,000 population. High-income countries recorded the highest ASMR at 0.71 deaths per 100,000 in 2021. Czechia had the highest unadjusted mortality rate at 3.27 cases per 100,000. Among age groups, the highest number of deaths was observed in the 70-74 age group with 4,857 deaths, followed by the highest DALYs in the 65-69 age group with 119,593 in 2021. Males experienced a greater increase in deaths and DALY rates compared to females (96% vs 59% for deaths, 79% vs 46% for DALYs) from 1990-2021.

Conclusion

KC attributable to H-BMI accounted for 20.01% of all KC-related deaths in 2021. There is a pressing need to implement public health policies focused on managing BMI and to enhance awareness and education about the risks through health news media and public influencers.