Abstract: PUB398
Burden of Acute Glomerulonephritis in 204 Countries and Territories, 1990-2021: A Global Benchmarking Analysis
Session Information
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Waqas, Muhammad, Jinnah Sindh Medical University, Karachi, Sindh, Pakistan
- Irfan, Adan, Shalimar Medical and Dental College, Lahore, Pakistan
- Singh, Kushagrita, Government Medical College and Hospital,Chandigarh, Chandigarh, India
- Katam, Shruthi, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh, India
- Shandilya, Ashwinikumar, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, India
- Lakkimsetti, Mohit, Mamata Medical College, Khammam, Telangana, India
- Amin, Vishrant, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, Gujarat, India
- Patel, Juhi, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, Gujarat, India
- Desai, Hardik, Gujarat Adani Institute of Medical Science, Bhuj, Gujarat, India
Background
Acute Glomerulonephritis (AGN) poses an escalating threat to global health, significantly influencing morbidity and mortality rates. This study is the first of its kind to estimate the worldwide burden of AGN over three decades, inclusive of the initial two years of the COVID-19 pandemic, which significantly complicated the management of non-COVID cases.
Methods
Utilizing the GBD 2021 framework, we assessed the incidence, prevalence, mortality, disability-adjusted life years (DALYs), and years lived with disability (YLDs) of AGN globally, stratified by age, sex, year, and location.
Results
The total percentage change (TPC) in prevalence of AGN increased by 2% (95% UI: 2-3%) from 2019-2021. The highest unadjusted incidence rate (IR)was observed in Eastern Europe at 18.21 per 100,000 (95% UI: 15.39-21.43) in 2021, followed by the highest mortality rate (MR) in Central Latin America at 0.44 per 100,000 (95% UI: 0.38-0.51). Nationally, the highest IR was observed in North Korea at 33.51 per 100,000, while the highest MR was recorded in Mexico at 0.74 cases per 100,000 in 2021. The highest incidence count occurred in individuals aged 10-14 years with 52,933 cases, while the highest number of deaths was in those aged 75-79 years at 1,201 in 2021. Males continued to experience a higher burden of AGN over the last three decades.
Conclusion
In 2021, AGN led to 10,760 global deaths, underscoring the need for targeted strategies. Collaboration among public stakeholders, policymakers, and clinicians is essential to enhance detection, management, and reduce its global impact.