Abstract: TH-PO987
Trend Analysis of Kidney Failure and Metabolic Syndrome-Related Mortality, 1999-2020
Session Information
- Physical Activity and Lifestyle in Kidney Diseases
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan
- Chaudhary, Ahmed Jamal, Detroit Medical Center, Detroit, Michigan, United States
- Ahmad, Jawad, Detroit Medical Center, Detroit, Michigan, United States
- Azeem, Saleha, King Edward Medical University, Lahore, Pakistan
- Munir, Luqman, King Edward Medical University, Lahore, Pakistan
- Khalid, Amna, King Edward Medical University, Lahore, Pakistan
Background
End-stage renal disease which manifests as renal failure is one of the leading causes of death in America and when combined with a comorbidity like metabolic syndromes, has reasonable prevalence. Minor metabolic syndromes including lipomatosis, lipodystrophy, and tumor lysis syndrome increase the complications of renal failure by interfering with the function of the already diseased kidney to a greater extent which is often the underlying pathology.
The goal of this study is to explore the trends of mortality due to renal failure when combined with various minor metabolic syndromes like lipomatosis, lipodystrophy, and tumor lysis syndrome from 1999 to 2020 using the age-adjusted mortality rates to target inconsistencies in various epidemiological groups. These metabolic syndromes affect the overall survival outcome of patients with end-stage renal disease leading to worse outcomes.
Methods
We analyzed Death Certificates from the Centers for Disease Control and Prevention (CDC) Wide Ranging Online Data for Epidemiological Research (WONDER) database from 1999-2020. AAMR per 1,000,000 people and annual percent change (APC) with a 95% confidence interval were determined. We then used the Joinpoint Regression Program to obtain trends amongst demographic (race, ethnicity, gender, age) groups.
Results
There has been a steady rise in mortality from 1999 to 2015 with an annual percent change (APC) of 4.47 but from 2015 onward, a steep rise in mortality with an APC of 17.67 has been observed. Overall mortality for males has been higher and steady but APC for females followed an interesting trend as it declined from 2003 to 2007 but has risen since. African Americans have consistently had worse outcomes as APC since 1999 has been in the high 20s with it dropping down in the early to mid-2000s. South census region has crept up to be the region most affected which until 2012 was the Midwest.
Conclusion
Renal failure and metabolic syndromes-related mortality have experienced an uprise in the United States in recent years. Persistent demographic and geographic disparities in renal failure and associated metabolic syndromes’ mortality underscore the need for further investigation and intervention.