Abstract: FR-PO378
Trend Analysis of Hypertensive Heart and Kidney Disease-Related Mortality, 1999-2020
Session Information
- Hypertension, CVD, and the Kidneys: Epidemiology
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan
- Chaudhary, Ahmed Jamal, Detroit Medical Center, Detroit, Michigan, United States
- Munir, Luqman, King Edward Medical University, Lahore, Pakistan
- Khalid, Amna, King Edward Medical University, Lahore, Pakistan
- Buhadur Ali, Muhammad Khan, King Edward Medical University, Lahore, Pakistan
- Azeem, Saleha, King Edward Medical University, Lahore, Pakistan
Group or Team Name
- NEURALKEy.
Background
Hypertensive heart and renal disease is a significant complication of chronic hypertension. Hypertensive heart disease manifests as left ventricular hypertrophy, heart failure, and coronary artery disease, while hypertensive renal disease involves renal parenchymal damage and glomerular injury, leading to progressive kidney dysfunction.
In this study, we investigated the increasing mortality rates associated with hypertensive heart and renal disease in the United States from 1999 to 2020. We utilized age-adjusted mortality rates (AAMR) to identify disparities across various epidemiological groups.
Methods
Death certificates from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research) database were examined spanning the years 1999 to 2020. Analyses included determining age-adjusted mortality rates (AAMR) per 100,000 individuals and calculating the annual percent change (APC) with 95% confidence intervals. Trends among demographic groups, including race, gender, age, and urban/rural classification, were assessed using the Joinpoint Regression Program.
Results
142,363 mortalities due to Spinal Injuries were reported between 1999 and 2020. Overall AAMR showed an upward trend although inconsistently with an AAPC score of 5.225. From 1999 to 2007, the AAMR showed a decline from 1999 to 2001, with an APC of -19.16 then it showed a steady rise from 2001 to 2014, with an APC of 3.71 and finally it showed a rapid rise from 2014 to 2020 with an APC of 18.56. The AAMR itself rose from 16.405 in 1999 to 48.521 in 2020. The populations with the highest mortality rates were in African Americans and males. The geographical hotspots for mortality were urban and Southern region. Tests for parallelism revealed disparate trends across African Americans and Whites (p=0.00022), Northeastern and Southern regions (p=0.00022) and Large fringe metro and Medium Metro (p=0.00022).
Conclusion
The mortality due to the hypertensive heart and renal disease has been rising since 1999 which is very concerning. Furthermore, the disparity among the demographic variables requires more investigation, and the planning of targeted interventions.