Abstract: PUB433
Impact of Systemic Lupus Erythematosus on Cardiovascular Morphologic and Functional Phenotypes
Session Information
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Lin, Zishan, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
- Wang, Wenfeng, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
- Jiang, Bingjing, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
- He, Jian, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
- Xu, Yanfang, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
Background
Previous studies have established a correlation between systemic lupus erythematosus (SLE) and the cardiovascular system, but the potential causal implications of SLE on the cardiac and aortic morphology remain unclear. Cardiovascular magnetic resonance (CMR) imaging, a novel and non-invasive modality, uniquely assesses cardiovascular structure and function, serving as risk biomarkers. In this study, we conducted a Mendelian randomization (MR) analysis to ascertain the causal connection between SLE and CMR traits.
Methods
Genetic variants independently linked to SLE were selected from a genome-wide association study (GWAS) containing 5,201 cases and 9,066 controls as instrumental variables. A set of 82 CMR traits was obtained from a recent GWAS, serving as preclinical indicators to provide preliminary insights into the morphology and function of the four cardiac chambers and two aortic segments. Primary analysis employed a two-sample MR study using the inverse-variance weighted method. Heterogeneity testing, sensitivity analyses, and instrumental variable strength assessments confirmed the robustness of the findings.
Results
SLE exhibited a correlation with increased stroke volume (β=0.007, P=0.045), regional peak circumferential strain (β=0.013, 0.009, 0.013; P=0.002, 0.043, 0.006), and global peak circumferential strain of the left ventricle (β=0.010, P=0.022), as well as decreased left ventricular regional radial strain (β=-0.010, P=0.017) (Figure.).
Conclusion
This research presents evidence of a potentially causal association between traits of SLE and alterations in the structure and function of the cardiac and aortic systems, offering guidance for cardiac examinations and disease prevention in lupus patients.
Figure. Significant associations of genetically predicted SLE traits with cardiovascular magnetic resonance traits
Funding
- Government Support – Non-U.S.