Abstract: SA-PO333
Trend Analysis of Kidney Failure and Diabetes Mellitus-Related Mortality, 1999-2020
Session Information
- Diabetic Kidney Disease: Clinical Pathology, Diagnostic and Treatment Advances
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 702 Diabetic Kidney Disease: Clinical
Authors
- Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan
- Chaudhary, Ahmed Jamal, Detroit Medical Center, Detroit, Michigan, United States
- Sarfraz, Laiba, King Edward Medical University, Lahore, Pakistan
- Munir, Luqman, King Edward Medical University, Lahore, Pakistan
- Khalid, Amna, King Edward Medical University, Lahore, Pakistan
- Azeem, Saleha, King Edward Medical University, Lahore, Pakistan
- Fatima, Mahnoor, King Edward Medical University, Lahore, Pakistan
Group or Team Name
- NEURALKEy.
Background
The interrelation between renal failure and diabetes mellitus lies in insulin resistance . Diabetes mellitus type 2 is a metabolic syndrome resulting in hyperglycemia.High blood glucose causes nonenzymatic glycation of tissue proteins resulting in mesangial expansion. This increases the permeability of blood vessels by weakening the wall. This condition ultimately leads to renal failure as renal blood vessels are damaged. These negatively downgrade the quality of life of the survivors.
The mortality due to kidney failure in diabetes mellitus patients is on the decline in the United States. In this study we explored these trends from 1999-2020, using age adjusted mortality rates (AAMR) to pinpoint incongruities between epidemiological groups.
Methods
Our study conducted an in-depth search of the CDC Wonder database, based on the incidence of sequalae of stroke-related Age-Adjusted Mortality Rate (AAMR) per 100,000 individuals. Employing Join point Regression Analysis, we assessed Parallelism and computed Annual Percent Changes (APC) with a 95% Confidence Interval. For a p<0.05, the test of parallelism was considered significant for unparallel.
Results
From 1999 to 2020, a total of 726654 deaths were reported due to the kidney failure due to diabetes mllitus. The overall AAMR showed a decline from 1999 to 2012, with an APC of -0.81. However, following this the AAMR had a rapid decline started to rise from 2012 to 2015, with an APC of -48.20. Following this a rise was seen from 2015 to 2020, with an APC of 13.88. The populations with the highest mortality rates were in males and African Americans. The geographical hotspots for mortality were urban and Black or African American. Tests for parallelism revealed disparate trends across gender (p=0.00022), Black and White races (p=0.06), urban versus rural demographics (p=0.12), and Large Central Metropolitan versus Large fringe Metropolitan (p=0.12).
Conclusion
The mortality due to the kidney failute and diabetes mellitus was on a decline in the US until 2013. However, the recent rise in the mortality is concerning. Furthermore, the disparity among the demographic variables warrant more investigation, and the planning of targeted interventions.