Abstract: SA-PO037
Trace Element Intake and Major Adverse Kidney Outcomes in Critically Ill Patients with Severe Sepsis
Session Information
- AKI: Clinical, Outcomes, and Trials - Management
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Wang, Tsai-Jung, Taichung Veterans General Hospital, Taichung, Taiwan
- Chen, Cheng-Hsu, Taichung Veterans General Hospital, Taichung, Taiwan
Background
Acute Kidney Injury (AKI) is common in ICU and can lead to poor renal outcomes. The balance of trace elements (e.g., selenium, zinc, and copper) in AKI patients is often disrupted. This study aims to investigate the relationship between trace element intake and renal outcomes in critically ill patients with severe sepsis.
Methods
In this prospective cross-sectional and follow-up study, ICU patients with severe sepsis, older than 20 years, and who stayed in the ICU for >48 hours, excluding those with end-stage renal disease, were included. Major adverse kidney events (MAKE-28) were determined by one or more criteria (e.g., dialysis, sustained Cr doubling from baseline, or death) on the 28th day after ICU admission. The patients’ data were collected on the 1st day of ICU admission, and the mean 7-day nutrient intake from both enteral and parenteral nutrition was recorded.
Results
Of 80 patients, the mean age was 69.5 ± 14.2 years and 53 (66.25%) patients developed AKI on ICU admission. During follow-up, 28 (35%) patients experienced MAKE-28. After adjusting for age, gender, and APACHE II score, we found significant associations between nutritional intake and MAKE-28. Specifically, among patients who were admitted with AKI, there were significant correlations between various nutritional intake parameters and MAKE-28, including mean energy intake, mean carbohydrate intake, mean protein intake, and mean selenium/zinc/copper intake. However, for non-AKI patients, nutritional intake was not significantly associated with renal outcomes.
Conclusion
Our findings suggest that nutritional intake, including not only macronutrients but also trace elements plays a critical role in renal outcomes in critically ill patients, particularly those admitted with AKI.
Table. Adjusted odds ratios of MAKE-28 in critically ill patients stratified by AKI status on ICU admission.
Funding
- Government Support – Non-U.S.