Abstract: TH-PO051
Trend Analysis of Acute Kidney Failure-Related Mortality, 1999-2020
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Gul Yousaf Khan, Mohammad, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Ahmad, Hadia, King Edward Medical University, Lahore, Pakistan
- Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan
- Munir, Luqman, King Edward Medical University, Lahore, Pakistan
- Khalid, Amna, King Edward Medical University, Lahore, Pakistan
- Zil-E-Ali, Ahsan, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Farooq, Umar, Penn State College of Medicine, Hershey, Pennsylvania, United States
Group or Team Name
- NEURALKEy.
Background
Acute renal failure (ARF), is a sudden decline in kidney function, leading to the accumulation of waste products and electrolyte imbalances. It has various causes and poses risks to patients, including increased morbidity and mortality.
There is a growing incidence of fatalities attributed to ARF across the US. By employing age-adjusted mortality rates (AAMR), we examined variations across significant demographic variables and scrutinized shifts in mortality rates from 1999 to 2020.
Methods
We examined mortality data related to ARF acquired from the CDC WONDER (Wide-Ranging Online Data for Epidemiological Research) Database, from 1999-2020. Utilizing 95% confidence intervals, the Joinpoint Regression Program calculated annual percent changes (APC) and age-adjusted mortality rates (AAMR) per 1,000,000 individuals. For p<0.05, the parallelism test was deemed significant for non-parallel results.
Results
A total of 1,180,886 deaths have been reported in the US from 1999-2020 due to ARF. From 1999 to 2010, AAMR showed an upward trend, it declined from 2010 to 2018 and peaked again from 2018 to 2020, with an APC of 4.40 from 1999-2010, -2.28 from 2010 to 2018 and 11.28 from 2018 to 2020. Males, Blacks or African Americans, and people aged 85 years or above were the highest mortality populations. Heightened mortality rates were primarily concentrated in the southern, mid-western and non-metropolitan populations. Disparate trends were found in the tests for parallelism among male and female (0.0002), American Indian and Black (0.003), Asian and Indian American (0.002), Asian and Black (0.0013), Asian and Hispanic (0.042), Black and White (0.0004), Black and Hispanic (0.0002), White and Hispanic (0.0004) demographics. Test for parallelism shows disparity between large and small metropolitan (0.0002), large metropolitan and non-metropolitan(0.0002) areas, Northeast and Midwest (0.0002), Northeast and South (0.0002), Northeast and West (0.0002), Midwest and South (0.001).
Conclusion
Following a surge, the mortality rate attributed to ARF, having initially decreased to a certain extent, is now seeing a resurgence in the US, prompting concern. Certain demographics persistently exhibit higher mortality rates emphasizing the need for further research.