Abstract: PUB004
Trend Analysis of Kidney Disease and COVID-19-Related Mortality, 1999-2020
Session Information
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Gul Yousaf Khan, Mohammad, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan
- Munir, Luqman, King Edward Medical University, Lahore, Pakistan
- Khalid, Amna, King Edward Medical University, Lahore, Pakistan
- Zil-E-Ali, Ahsan, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Farooq, Umar, Penn State College of Medicine, Hershey, Pennsylvania, United States
Group or Team Name
- NEURALKEy.
Background
The interaction of kidney diseases and COVID-19 may present in various forms and may pose various challenges. Individuals with pre-existing kidney pathologies may face increased complications and risks if infected. On the other hand, some of the infected individuals with previously normal renal function have also been seen to develop AKI.
The mortality due to COVID related kidney diseases is on the rise in the United States. In this study we explored these trends from 1999-2020, using age adjusted mortality rates (AAMR) to pinpoint incongruities between epidemiological groups.
Methods
Our study conducted an in-depth search of the CDC Wonder database, based on the incidence of sequalae of stroke-related Age-Adjusted Mortality Rate (AAMR) per 100,000 individuals. Employing Join point Regression Analysis, we assessed Parallelism and computed Annual Percent Changes (APC) with a 95% Confidence Interval. For a p<0.05, the test of parallelism was considered significant for unparallel.
Results
From 1999-2020, a total of 4778965 deaths were reported due to COVID related kidney diseases. The overall AAMR showed a rise from 1999-2011, with an APC of 0.38. Following this, the AAMR started to decline from 2011-2014, with an APC of -11.94. The AAMR then showed a rise again from 2014-2020, with an APC of 1.50. The highest mortality populations were males and African Americans. The geographical hotspots for mortality were rural and Midwest. Tests for parallelism revealed disparate trends across gender (p=0.0002), Black and White races (p=0.0089), urban versus rural demographics (p=0.001). However, the parallelism test in Midwest versus South (p=0.25) was not significant.
Conclusion
The recent rise in the mortality due to COVID related kidney diseases is concerning. Furthermore, the disparity among the demographic variables warrants more investigation, and the planning of targeted interventions.