Kidney Week

Abstract: FR-PO373

Trend Analysis of Hypertensive Kidney Disease-Related Mortality, 1999-2020

Session Information

• Hypertension, CVD, and the Kidneys: Epidemiology
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Gul Yousaf Khan, Mohammad, Penn State College of Medicine, Hershey, Pennsylvania, United States

Mohammad Gul Yousaf Khan, MD, MBBS

• Khan, Hammad H., King Edward Medical University, Lahore, Pakistan

Hammad H. Khan

• Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan

Mohammad Ammar ur Rahman, MBBS

• Munir, Luqman, King Edward Medical University, Lahore, Pakistan

Luqman Munir

• Khalid, Amna, King Edward Medical University, Lahore, Pakistan

Amna Khalid

• Qureshi, Ali Akram, King Edward Medical University, Lahore, Pakistan

Ali Akram Qureshi, MBBS

• Shahid, Iqra, King Edward Medical University, Lahore, Pakistan

Iqra Shahid, APN, APRN, CAE

• Zil-E-Ali, Ahsan, Penn State College of Medicine, Hershey, Pennsylvania, United States

Ahsan Zil-E-Ali, MBBS, MPH

• Farooq, Umar, Penn State College of Medicine, Hershey, Pennsylvania, United States

Umar Farooq, MD, MS, FASN

• Abid, Fatima H., King Edward Medical University, Lahore, Pakistan

Fatima H. Abid

Group or Team Name

• NEURALKEy.

Background

Hypertensive kidney disease is associated with significant mortality because of the associated end-organ damage. This study seeks to evaluate the trend disparities in mortality related to hypertensive kidney disease among various demographic and geographical variables.

Methods

Our research involved a comprehensive analysis of the CDC Wonder database, specifically focusing on hypertensive kidney disease-related age-adjusted mortality rate (AMR) per 1,000,000 people. We conducted a test of Parallelism and calculated Annual Percent Changes (APC) with 95% Confidence Intervals using Joinpoint Regression Analysis. The test of parallelism was deemed significant for unparallel results with a p-value < 0.05.

Results

Overall AMR for hypertensive kidney disease did not significantly change from 1999 to 2020. However, AMR declined from 1999 to 2012 (APC -3.83), followed by a significant increase till 2020 (APC 5.70). All age groups from 25-85+ experienced a significant increase in AMR, with the 85+ having the greatest APC (14.4). There was a significant increase in AMR across all four census regions, with greatest increase in C2: Midwest (APC 11.2). The regions did not differ significantly from one another. Both urban and rural populations saw a significant increase in AMR, with rural population having a significantly greater APC (11.4). The female population experienced a significant decline in AMR, with a significantly negative AAPC of -1.30. The AAPC did not differ significantly between the two genders. The parallelism test was significant for comparison of genders, census regions and urban/rural populations. The Asian or Pacific Islander population experienced a decline in AMR (APC -2.80), with Black population experiencing a significant decrease from 1999-2018 (APC -3.61), followed by a substantial and significant increase till 2020 (APC 24.4).

Conclusion

Hypertensive kidney disease-related mortality has experienced little change in the United States. Certain demographic groups such as the rural population, females, and recently, the Black population experience disparities which require further investigations and directed solutions for these groups.