Abstract: FR-PO942
Trend Analysis of Renal Tubulointerstitial Disease-Related Mortality, 1999-2020
Session Information
- Glomerular Diseases: Potpourri
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan
- Chaudhary, Ahmed Jamal, Detroit Medical Center, Detroit, Michigan, United States
- Moazzam, Eisha, King Edward Medical University, Lahore, Pakistan
- Munir, Luqman, King Edward Medical University, Lahore, Pakistan
- Khalid, Amna, King Edward Medical University, Lahore, Pakistan
- Aftab, Haram, King Edward Medical University, Lahore, Pakistan
- Ijaz, Azka, King Edward Medical University, Lahore, Pakistan
Group or Team Name
- NEURALKEy.
Background
Renal tubulointerstitial disease is a term which encompasses primary injury of renal structures resulting in inflammation of kidney and the surrounding tissues (interstitial tissues), hence it is also referred to as tubulointerstitial nephritis. It can a result of a hypersensitivity reaction to certain medications, exposure to heavy metals and infections. For treatment, removing the causative agent is preferred followed by corticosteroid therapy.
The aim of this study was to analyze the trend of deaths as a result of renal tubulo-interstitial disease in the US from 1999 to 2020 using age-adjusted mortality rate (AAMR) and to identify variations among key demographic variables.
Methods
We obtained death certificates from 1999 to 2020 from the website of Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER). AAMR per 1,000,000 people and annual percent change (APC) with 95% confidence interval were determined. Joinpoint Regression Program was used to determine trends among demographics groups (gender, age, race, urban/rural).
Results
In total, 7,341 deaths due to renal tubulointerstitial diseases were recorded. The age-adjusted mortality rate (AAMR) surged from 15.228 in 1999 to 17.962 in 2020. The annual percentage change (APC) in AAMR indicated following trends: from 1999 to 2011, the APC was -2.1150, demonstrating a decline; from 2011 to 2018, the APC rose to 3.8974; and from 2018 to 2020, the APC showed a noticeable peak at 9.5021.
On analysis, higher mortality rates were recorded among Black individuals, those living in rural areas, the residents of western region, males, and individuals aged 85 years and older.
Conclusion
The mortality rate due to renal tubulointerstitial diseases has experienced a concerning rise in the last two decades. Persistent disparities among the demographic variables highlight the need for further investigation and intervention.