Kidney Week

Abstract: SA-PO202

Trend Analysis of Kidney Neoplasms-Related Mortality, 1999-2020

Session Information

• Onconephrology: Kidney Outcomes during Cancer Treatment and Nephropathies
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Onconephrology

• 1700 Onconephrology

Authors

• Gul Yousaf Khan, Mohammad, Penn State College of Medicine, Hershey, Pennsylvania, United States

Mohammad Gul Yousaf Khan, MD, MBBS

• Ammar ur Rahman, Mohammad, King Edward Medical University, Lahore, Pakistan

Mohammad Ammar ur Rahman, MBBS

• Azeem, Saleha, King Edward Medical University, Lahore, Pakistan

Saleha Azeem, MBBS

• Munir, Luqman, King Edward Medical University, Lahore, Pakistan

Luqman Munir

• Khalid, Amna, King Edward Medical University, Lahore, Pakistan

Amna Khalid

• Shaukat, Muhammad Talha, King Edward Medical University, Lahore, Pakistan

Muhammad Talha Shaukat, MBBS

• Zil-E-Ali, Ahsan, Penn State College of Medicine, Hershey, Pennsylvania, United States

Ahsan Zil-E-Ali, MBBS, MPH

• Farooq, Umar, Penn State College of Medicine, Hershey, Pennsylvania, United States

Umar Farooq, MD, MS, FASN

• Rehman, Wania, King Edward Medical University, Lahore, Pakistan

Wania Rehman, MBBS

Group or Team Name

• NEURALKEy.

Background

Renal neoplasms represent conditions with prognoses of varying severity depending on the tumor subtype. These neoplasms entail the abnormal proliferation of cells within kidney tissues, characterized by hematuria, localized flank or lumbar mass, extended pyretic episodes, weight reduction and edema in lower extremities. Early detection is critical to intervention, as renal neoplasms are amenable to treatment in their initial stages but may pose an imminent risk in advanced phases.
This study aims to evaluate the incidence and mortality rates of kidney neoplasms from 1999 to 2020.

Methods

We examined mortality data for kidney neoplasms from 1999 to 2020 acquired from CDC Wonder Database. The AAMR per 100,000 people and annual percentage change (APC) with 95% confidence intervals were computed. We looked for substantial tests of parallelism that revealed different trends. To determine overall trends and variations in main demographic groupings (gender, race, age, and urban/rural), the Joinpoint Regression Programme was used.

Results

Between the years 1999 and 2020, a total of 275,905 fatalities linked to Kidney neoplasms were documented. An observed pattern of decreasing trend in the AAMR was significant throughout this period. Specifically, there was an APC of 2.34 from 1999 to 2001 followed by a decrease to -1.91 from 2001 to 2020. The analysis additionally demonstrated elevated rates of mortality in subpopulations characterized by male gender, African American and White ethnicities, as well as individuals residing in urban areas.

Conclusion

Between 1999-2020, the United States has witnessed a decline in mortality rates associated with kidney neoplasms, a trend ostensibly due to advancements in medical care and the deployment of comprehensive vaccination programs. Nevertheless, the persistently elevated mortality rates within certain demographic cohorts underscore a critical need for further research to address these disparities. It is imperative that future endeavors focus not only on the general population but also on those subgroups disproportionately affected by kidney neoplasms.