Abstract: TH-PO311
A Comparative Study of Health-Related Quality of Life between Patients on Maintenance Hemodialysis and Kidney Transplant Recipients
Session Information
- Hemodialysis and Frequent Dialysis - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Waziri, Bala, Ibrahim Badamasi Babangida University, Lapai, Nigeria
- Nalado, Aishatu Muhammad, Aminu Kano Teaching Hospital, Kano, Kano, Nigeria
Background
It is generally recommended that patients with end stage kidney disease (ESKD) should be offered kidney transplantation, as this modality of renal replacement therapy (RRT) has been shown to improve health related quality of life (HRQOL) and a better life expectancy.
Methods
This cross-sectional multicenter study included KTRs with functioning grafts and patients on MHD from three major transplant centers and five dialysis units in Nigeria. Quality of life was assessed with the Kidney Disease QOL-SF-36 (version 1.3) questionnaire. Multivariable linear regression was used to assess differences in mean HRQOL scores between KTRs and HD patients.
Results
Four hundred and ninety-nine (293 HD patients, 98 KTRs, and 108 healthy controls) participants were enrolled into the study. Both HD patients (47.2±14.0 years) and KTRs (46.5±11.4 years) were significantly older than the healthy controls (32.2±9.7 years, p<.0001). Higher proportion of KTRs (81.6%) obtained tertiary education as compared with HD patients (66.9%). The distribution of gender was similar between HD patients and KTRs.
With the exception of bodily pain, KTRs had significantly higher HRQOL mean scores in the eight subscales of the SF-36 than HD patients: physical functioning (73.8 ±25.3 versus 52.7±27.5;p<.0001), log role-physical (4.4±0.4 versus 3.8±0.6; p<.0001), bodily pain (79.1±25.8 versus72.7±25.5; p=0.10) , general health (73.8±23.2;p<.0001), vitality( 65.1±15.0 versus 57.2 ;p=0.002), social functioning (62.5±24.6 versus 50.6±25.0; p<.0001), log role emotional (4.3±0.4 versus 4.1±0.5; p=0.01) and mental health (84.7±16.7 versus 72.3±17.9; p<.001). Except for mental health and social functioning, the subscale scores and the two Mental Component Summary (MCS) and Physical Component Summary (PCS) measures for KTRs and healthy controls did not differ. KTRs have higher PCS (46.8±9.1 versus 38.2±8.8; p< .0001) and MCS (50.1±8.1 versus 43.9±9.1; p<.0001) scores than HD patients.
Having kidney transplant is significantly associated with higher PCS score (β coefficient: 8.33; 95% confidence interval: 5.08- 11.58; P<.0001) and higher MCS score (β coefficient: 6. 29; 95% confidence interval: 3.11-9.47; P<.0001).
Conclusion
Kidney transplant recipients have a better health related quality of life than hemodialysis patients and comparable HRQOL scores to healthy individuals
Funding
- Private Foundation Support