Kidney Week

Abstract: FR-OR95

Assessing Kidney Function in Pregnancy

Session Information

• Women's Health and Kidney Diseases: From Bench to Bedside
  October 25, 2024 | Location: Room 24, Convention Center
  Abstract Time: 05:10 PM - 05:20 PM

Category: Women's Health and Kidney Diseases

• 2200 Women's Health and Kidney Diseases

Authors

• Clark, Katherine Rose, King's College London, London, United Kingdom

Katherine Rose Clark, MS, MSc

• Dalrymple, Kathryn, King's College London, London, United Kingdom

Kathryn Dalrymple, PhD

• Snowball, Olivia, King's College Hospital, London, London, United Kingdom

Olivia Snowball, MSc

• Judah, Hannah Rose, King's College Hospital, London, London, United Kingdom

Hannah Rose Judah, MBBS

• Syngelaki, Argyro, King's College London, London, United Kingdom

Argyro Syngelaki, PhD

• Nicolaides, Kypros, King's College Hospital, London, London, United Kingdom

Kypros Nicolaides, MBBS

• Bramham, Kate, King's College London, London, United Kingdom

Kate Bramham, MBBS, PhD

Background

Deterioration in maternal kidney function is associated with morbidity and mortality for mother and baby.This study aims to define normal centile ranges in pregnancy for serum creatinine, urea, cystatin c and beta-2-microglobulin.

Methods

Prospective cohort study of women at two UK hospitals(2018-2021).
Inclusion criteria:6+ weeks gestation, singleton pregnancy.
Exclusion criteria:renal disease; previous AKI; chronic hypertension; diabetes; connective tissues disease; thrombophilia; cardiovascular disease.
Venous serum samples taken at routine ultrasound scans.
Participants who developed a risk factor for AKI were excluded from the centiles.
Xrigls command was used in Stata 18.0 to allow reference interval estimation using generalized least squares.

Results

739 participants. 644(87.1) had an uncomplicated pregnancy and delivery, 95(12.9%) developed a risk for AKI(T.1).
Cystatin C had greater variability with increasing gestation even in those with no risk factors(F.1). Figure 2 shows centile charts for all biomarkers for those with no AKI risk factors with detail provided for serum creatinine(F.3).

Conclusion

In this ethnically diverse study creatinine values were lower than reported with >63umol/l at any gestation above the 97^thcentile. Cystatin C and beta-2-microglobulin vary increasingly towards term, even in women with no AKI risk factors thus are unlikely to be useful biomarkers.