Kidney Week

Abstract: FR-PO1099

Age-Specific Estimated Glomerular Filtration Rate for Mortality Prediction in the Korean Population: A Retrospective Kangbuk Samsung Health Cohort Study

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 2
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Lee, Kyu-Beck, Kangbuk Samsung Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Kyu-Beck Lee, MD

• Yang, Jihyun, Kangbuk Samsung Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Jihyun Yang, MD, PhD

• Hyun, Young Youl, Kangbuk Samsung Hospital, Jongno-gu, Seoul, Korea (the Republic of)

Young Youl Hyun, MD, PhD

Background

With the advance of the glomerular filtration rate (GFR) formula and the recognition of age-related variations, there is a concern regarding the need to reconsider/adapt a distinct GFR equation for the elderly. We conducted a comparative analysis of the predictive accuracy of CKD-EPI 2009, 2021 (race-free) and the European Kidney Function Consortium (EKFC) equation for mortality prediction across different age groups.

Methods

We analyzed 670,320 participants who underwent a comprehensive health examination, enrolled in Kangbuk Samsung Health Cohort from January 1, 2002 to December 31, 2019 and followed them up for mortality until December 2019. The age group was divided from 18 to 39, 40-64, and over 65 years old (group 1,2,3).

Results

The participants’ median follow-up period was 8.8 years, mean age was 39.8 years old (minimum 18, maximum 97), and 53.6% were male. Mean eGFR using 2009 CKD-EPI was 95.1 ml/min/1.73m², 100.6 ml/min/1.73m² using 2021 CKD-EPI, 94.0 ml/min/1.73m² using EKFC. There was no difference between the equations in group 1. Discriminatory power for all-cause mortality prediction was the best when using EKFC in group 2 and group 3. Moreover, the EKFC showed better discriminatory power for CVD mortality in all age groups.

Conclusion

The EKFC equation showed better prediction and explanation in middle age to the elderly.