Abstract: FR-PO375
Global and Regional Disease Burden of Hypertensive CKD, 1980-2021: An Analysis of GBD Study 2021
Session Information
- Hypertension, CVD, and the Kidneys: Epidemiology
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Shah, Badar U Din, Geisinger Health, Danville, Pennsylvania, United States
- Shaukat, Muhammad Talha, King Edward Medical University, Lahore, Pakistan
- Rehman, Wania, King Edward Medical University, Lahore, Pakistan
- Rehman, Aqeeb Ur, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
- Mohsin, Aleenah, Brown University, Providence, Rhode Island, United States
- Ahmad, Shahzaib, Baptist Health South Florida Inc, Coral Gables, Florida, United States
- O'Bell, John W., Brown University, Providence, Rhode Island, United States
Background
The incidence of hypertensive Chronic Kidney Disease(CKD) has steadily risen over time. The trends of standardized mortality and morbidity of hypertensive CKD are, however, understudied. By analysing trends from 1980-2021, this study provides insight into the longitudinally evolving pattern of hypertensive CKD associated mortality and morbidity.
Methods
Data were extracted from the Global Burden of Diseases (GBD) study, encompassing age-standardized mortality rates (ASMR), Years of Lost Life (YLL), and Disability-Adjusted Life Years (DALYs). The dataset was stratified by continent, with Africa divided into Northern, Southern, Eastern, Western, and Central. Data was further stratified by World Bank income levels and Joinpoint regression determined average annual percentage change (AAPC).
Results
Globally, the Age Standardized Death Rates (ASDR) for hypertensive CKD had an overall incline from 1980-2021. In 1980, ASDR was 4.57 (95% UI:3.8–5.5), which increased to 5.53 (AAPC:0.486; 95% CI:0.415, 0.557) in 2021. Globally, the DALYs were 107.7 (95% UI:91.26-126.9) per 100,000 people in 1990, and climbed to 128.4 (AAPC: 0.566; 95% CI:0.485-0.684) in 2021. From 1990 to 2021, the YLL showed a uniform spike with an AAPC of 0.287 (95% CI:0.19–0.37). In geographical analysis, all continents except Asia had an overall increase in ASDRs, with the highest ASDRs in Africa, and the most prominent spike in America. From 1980-2021, America had AAPC of 1.32 (95% CI:1.15-1.50), Africa had 0.403 (95% CI:0.34-0.46), Europe had 0.54 (95% CI:0.20-0.89) while Asia had -0.19 (95% CI:-0.29- -0.08). Central and Western Africa had the highest ASDRs as compared to other regions of the continent. Upon subanalysis of America, Mississippi and Louisiana had the most prominent incline in ASDRs. According to the World Bank income levels, low and middle income countries(LMICs) also conformed to the global trend and had an increasing death rates trends.
Conclusion
This study reveals a global rise in ASDR for hypertension-related CKD. Moreover, DALYs and age-standardized YLL have also increased, underscoring the need for targeted interventions as well as preventive measures. LMICs also show escalating death rates, emphasizing the need for proactive measures to address this growing health crisis there.