Kidney Week

Abstract: PUB100

Hungry Bone Syndrome (HBS) as an Outcome of Parathyroidectomy for Treatment of Hyperparathyroidism in a Third-Level Hospital in a Medium-Income Country

Session Information

• Publication Only

Category: Bone and Mineral Metabolism

• 502 Bone and Mineral Metabolism: Clinical

Authors

• García, Nicte Alaide Ramos, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Nicte Alaide Ramos García, MSc

• Gonzalez-Fuentes, Carolina, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Carolina Gonzalez-Fuentes, MD, MSc

• Hopf, Karen, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Karen Hopf, MD

• Salazar Hurtado, Jorge David, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Jorge David Salazar Hurtado, MD

• Camacho Luna, Manuel, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Manuel Camacho Luna, MD

• Sánchez, Michelle, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Michelle Sánchez, MSc

• Alamilla-Sanchez, Mario, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Mario Alamilla-Sanchez, MD, MSc

• Carbajal, Martin Omar, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico City, Mexico

Martin Omar Carbajal, MEd, ScD

Background

Hyperparathyroidism is a common disorder of mineral metabolism that is due to excessive secretion of PTH from one or more of the four parathyroid glands. It can be classified as primary, secondary and tertiary. In ESRD the definitive treatment in severe disease is parathyroidectomy. HBS is one complication after the surgery.

Methods

Retrospective cohort study with information (Jan 2023 and Jan 2024) in a third level hospital “Centro Médico Nacional 20 de Noviembre”. The goal was to describe and analyze the incidence of HBS on patients with hyperpharatidoidism primary, secondary and tertiary treated with parathyroidectomy. We made a Principal Component Analysis (PCA) to observe the factors that have more impact.

Results

51 cases were included. There were 16 patients with primary, 29 patients with secondary and 5 with tertiary hyperparathyroidism. Patients with ERSRD with secondary and tertiary hyperparathyroidism were mainly in Hemodialysis (71%) as Kidney Replacement Therapy (n=25). The mean value of PTH before surgery was 728 pg/ml among all patients. 80% patients (n=41) have AP >100 mg/dl as a parameter of high bone replacement. 30% patients (n=15) develop hungry bone syndrome. 86% of patients (n=13) that developed HBS have 3 ½ surgery. We made a PCA we observed that the principal components that predict to developed HBS in our population were AP, PTH and the surgery 3 ½ and patients have more risk if they have the three of them together.

Conclusion

The principal components observed that predict the developed HBS in our population were AP, PTH and the surgery 3 ½ and patients have more risk to develop HBS if they have them together.