Kidney Week

Abstract: TH-PO871

Demographics and Trends of Uropathy-Associated Mortality in the United States, 1999-2020

Session Information

• Race, Ethnicity, and Gender in Kidney Health and Care
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Diversity and Equity in Kidney Health

• 900 Diversity and Equity in Kidney Health

Authors

• Shah, Badar U Din, Geisinger Medical Center, Danville, Pennsylvania, United States

Badar U Din Shah, MD

• Shaukat, Muhammad Talha, King Edward Medical University, Lahore, Punjab, Pakistan

Muhammad Talha Shaukat, MBBS

• Rehman, Wania, King Edward Medical University, Lahore, Punjab, Pakistan

Wania Rehman, MBBS

• Hayat, Malik Saad, King Edward Medical University, Lahore, Punjab, Pakistan

Malik Saad Hayat, APN

• Bhatti, Muhammad Imaz, King Edward Medical University, Lahore, Punjab, Pakistan

Muhammad Imaz Bhatti

• Mohsin, Aleenah, Brown University, Providence, Rhode Island, United States

Aleenah Mohsin, MD, MBBS

• Rehman, Aqeeb Ur, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States

Aqeeb Ur Rehman, MBBS, MD

Background

Uropathy/ obstructive uropathy is a progressively growing cause of mortality and morbidity in the United States. In this study, we aimed to analyze trends of uropathy-related mortality in the US from 1999-2020. Understanding the epidemiology and trends would help guide in better management and consequently improve outcomes.

Methods

Data was extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research (CDC WONDER) database from 1999-2020. Age-adjusted mortality rate (AAMR) per 100,000 individuals and annual percent changes (APC) with 95% Confidence Intervals (CI) were calculated using Joinpoint regression analysis. Data were also stratified to account for gender, race, locale and patient population.

Results

A total of 56,521 uropathy-related deaths were identified from 1999-2020. There was an overall decline in the AAMR from 1990 to 2011 followed by a gradual rise from 2011 to 2020 with an APC of -1.7457 and 5.6503 respectively. The analysis revealed significant disparities in mortality rates among different demographic groups. The mortality rates were found to be higher in male patients (AAPC:0.08% (95% CI -0.63 to 0.79)) and white/non-Hispanic patients (AAPC:1.5% (95 % CI 0.84 to 2.26)). There was no statistically significant difference between the mortality rates of metropolitan (AAPC:1.24% (95% CI 0.5845 to 1.8938) and non-metropolitan areas (AAPC: 1.29% (95% CI 0.33 to 2.45)). A higher proportion of uropathy-related mortality occurred in the Southern regions of the country and most deaths occurred among the in-patient population.

Conclusion

Though there has been an overall decline in mortality associated with uropathy from 1999-2011, a progressively rising trend from 2011 highlights the need for targeted research and interventions to address demographic disparities and regional healthcare inequities.

Uropathy associated mortality trends across different races