Abstract: SA-PO938
Epidemiology of Biopsy-Confirmed Kidney Disease: A Single-Practice Study in South Texas
Session Information
- Pathology and Lab Medicine - 2
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pathology and Lab Medicine
- 1800 Pathology and Lab Medicine
Authors
- Saldivar, Klarissa A., University of the Incarnate Word, San Antonio, Texas, United States
- Khan, Umar, University of the Incarnate Word, San Antonio, Texas, United States
- Zavala Georffino, Julio Paolo, University of the Incarnate Word, San Antonio, Texas, United States
Background
Prevalence of biopsy-proven kidney disease in the United States (US) is fairly limited, especially in Hispanic populations who experience a large burden of kidney disease. This study is aimed to determine the patterns and epidemiological features of kidney disease in a predominantly hispanic population of South Texas.
Methods
Using data from a single nephrology practice in Laredo, TX, we identified patients who underwent kidney biopsies from April 2014 to April 2024. Retrospective analysis was done to obtain demographics, histopathologic diagnosis, and clinical/laboratory data. Results were stratified by age, gender, race/ethnicity, and comorbidities to identify epidemiologic patterns.
Results
Of 260 patients, transplant biopsies and those with insufficient data were excluded, leaving 240 patients for analysis. The median age was 50 years, with 57% female patients. Racial/ethnic demographics included 97% Hispanic patients. Secondary Glomerular Diseases (SGD) were most common with prevalence of 50%, followed by Primary Glomerular Diseases (PGD) (38%) and Tubulointerstitial Diseases (TID) (12%). Diabetic kidney disease (DKD) (n=94, 39%) and lupus nephritis (LN) (n=17, 7%) were the most common SGD, whereas IgA nephropathy (IgAN) (n=17, 7%), AA amyloidosis (n=13, 5), membranous nephropathy (MN) (n=11, 5%), and focal segmental glomerulosclerosis (FSGS) (n=11, 5%) were the most common PGD. The most common TID was acute tubular necrosis (ATN) (n=20, 8%). Of patients with FSGS, MCD, and LN ≥ 70% were female. Of patients with amyloidosis, FSGS, Thrombotic microangiopathy (TMA), and LN > 85% were ≤ 50 years of age.
Conclusion
Our study describes the prevalence of biopsy-proven kidney diseases in a Hispanic population. This provides a foundation to better understand patterns for kidney disease in a population underrepresented in literature, and contributes to the current lack of kidney biopsy data in the US.