Abstract: FR-PO940
Demographics and Trends of Tubulointerstitial Nephritis-Related Mortality in the United States, 1999-2020
Session Information
- Glomerular Diseases: Potpourri
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Shah, Badar U Din, Geisinger Health, Danville, Pennsylvania, United States
- Rehman, Wania, King Edward Medical University, Lahore, Pakistan
- Shaukat, Muhammad Talha, King Edward Medical University, Lahore, Pakistan
- Hayat, Malik Saad, King Edward Medical University, Lahore, Pakistan
- Shoaib, Muhammad Mukarram, King Edward Medical University, Lahore, Pakistan
- Rehman, Aqeeb Ur, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
- Mohsin, Aleenah, Brown University, Providence, Rhode Island, United States
- O'Bell, John W., Brown University, Providence, Rhode Island, United States
Background
The incidence of tubulointerstitial nephritis as a cause for mortality is on the rise in the US. In this study, we aim to investigate the patterns of mortality associated with it spanning from 1999 to 2020 in the United States.
Methods
Data was extracted from the CDC WONDER database from 1999 to 2020. Age-adjusted mortality rate (AAMR) per 100,000 individuals and annual percent changes (APC) with 95% Confidence Intervals (CI) were calculated using Joinpoint regression for different epidemiological cohorts stratified by gender, race, and locale (metropolitan vs. non-metropolitan).
Results
From 1999 to 2020, a total of 37,611 deaths were reported due to tubulointerstitial nephritis. The overall AAMR showed a gradual decline from 1999 to 2012 followed by a progressively increasing trend from 2012-2020, with an APC of -2.1853 and 5.0345 respectively. The analysis revealed significant disparities in mortality rates among different demographic groups and geographical regions. The mortality rates were found to be higher in female patients (AAPC: 0.3% (95% CI -0.74 to 1.35)), Latino/Hispanic patients (AAPC: 1.5% (95 % CI 0.87 to 3.97)) and residents of metropolitan areas (AAPC: 1.22% (95% CI -1.75 to 4.28)).
Conclusion
Our study revealed an increasing trend of tubulointerstitial nephritis-related mortality from 2012 onwards with demographic and geographical disparities, which underscores the necessity for further research to address these disparities and mitigate the rising mortality associated with tubulointerstitial nephritis.
Trends of mortality due to tubulointerstitial nephritis across different races in the United States;1999-2020