Abstract: TH-PO966
Effect of a Low-Protein Diet Supplemented with Ketoanalogues on Body Composition and Hand Grip Strength of Elderly Mexican Patients with CKD Attending a Nutritional Care Center
Session Information
- Physical Activity and Lifestyle in Kidney Diseases
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Aldana Solis, Nadia Iracema, Fresenius Kabi Mexico SA de CV, CDMX, CDMX, Mexico
- Espinoza, Abril Gutiérrez, Fresenius Kabi Mexico SA de CV, Tijuana, Baja California, Mexico
- Nava, Julia, Fresenius Kabi Mexico SA de CV, CDMX, CDMX, Mexico
- Salinas Rico, Adriana, Fresenius Kabi Mexico SA de CV, CDMX, CDMX, Mexico
- Aguilar Gamiño, Araceli, Fresenius Kabi Mexico SA de CV, CDMX, CDMX, Mexico
- De La Rosa Diez, Sara, Fresenius Kabi Mexico SA de CV, CDMX, CDMX, Mexico
- Kopple, Joel D., The Lundquist Institute, Torrance, California, United States
Background
Chronic kidney disease has become one of the significant causes of mortality in the world. Nutritional therapy is one of the cornerstones of conservative management. Elderly subjects with CKD are considered a frail population. An LPD supplemented with keto analogs and adequate energy supply could be an option for treatment to avoid or differ dialysis and maintain a good nutritional status and muscle strength.
Methods
This was a retrospective analysis of 60 patients with CKD stages 3b-5. The data were collected from the database of one Fresenius Kabi CEAN center in Mexico City. The study included nondiabetic and diabetic patients who were ≥65 years old. Each patient was prescribed a sk-LPD individualized according to the patients GFR level, nutritional status, and specific tastes. Biochemical, body composition, HGS, and nutritional screening parameters were compared between baseline and at a six-month interval.
Results
The patient population was 41.7% female and 43.3% diabetic. At the onset of dietary treatment, according to the BMI criteria, 41.7% were normal weight; 43.3% were overweight, and 15% obese. After six month’s treatment, 45% were normal weight, 38.3% were overweight, and 16.7% obese (change in weight status: p=NS). Fat mass tended to decrease from 37.2±10.0 to 35.5±8.9% p=0.32; lean body mass did not change, 47.5±16.1% to 48.4±17.0% p=0.76; and phase angle tended to decrease although not significantly, 4.49±2.37 to 4.02±0.73, p=0.080. HGS was maintained 21.6 ±7.6 to 21.7 ±8.0 kg p=0.109. Serum urea nitrogen (SUN) decreased at six months from 47.9±21.8 to 33.7±17.2 mg/dL, p<0.001. Serum albumin was maintained, 4.14±0.40 to 4.14±0.40 g/dL, p=0.722, eGFR increased from 25.0±10.3 to 29.4±13.0 ml/min/1.73 m2 p=0.042.
Conclusion
The major decrease in SUN during the study suggests at least fair to good adherence to the prescribed diets. No significant changes were noticed in anthropometric, biochemical, HGS and other nutritional characteristics during this six-month interval, suggesting that the sk-LPD treatment maintained nutritional status in these older stage 3b-5 CKD patients.