Abstract: TH-PO115
Baclofen Toxicity in Patients with Impaired Kidney Function: A Review of Cases in the Literature
Session Information
- Pharmacology
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pharmacology (PharmacoKinetics, -Dynamics, -Genomics)
- 2000 Pharmacology (PharmacoKinetics, -Dynamics, -Genomics)
Authors
- Rehman, Amna, Berkshire Medical Center, Pittsfield, Massachusetts, United States
- Parada, Xavier F., Berkshire Medical Center, Pittsfield, Massachusetts, United States
Background
Baclofen is a gamma-aminobutyric acid derivative that inhibits presynaptic motor neurons, resulting in central anti spasticity. It is commonly used to treat muscle spasticity caused by central nervous system disorders. Baclofen neurotoxicity cases are usually iatrogenic but are poorly recognized resulting in significant health problems, mortality, and hospital resource utilization. Therefore, we present here a review of cases published in literature in regard to baclofen induced toxicity in patients with impaired renal function.
Methods
We searched pubmed database for key words: baclofen (adverse effects, poisoning, toxicity), chronic kidney failure, chronic renal insufficiency, end stage renal disease (Figure 1).
Results
We reviewed 12 published articles, with 16 patients of avg. CKD stage IV or V who received variable baclofen dose and developed neurotoxicity (Figure 2).
Conclusion
Our review emphasizes the association of baclofen use with adverse side effects in patients with chronic kidney disease including encephalopathy, dyskinesia, lethargy and tremors. The review highlights that as providers we need to recognize contraindications of baclofen use in patients with impaired renal function and consider other treatment options. Another important aspect is that there are currently no clear guidelines for dosing of baclofen in patients with decreased kidney function. Finally, the management of baclofen toxicity remains variable with no standard recommendations especially for patients with chronic kidney disease.