Kidney Week

Abstract: FR-PO1146

Intramuscular Adipose Tissue (IMAT) Accumulation and Muscle Function in Patients with Moderate to Advanced Kidney Disease

Session Information

• CKD: Kidney Function and Extrarenal Complications
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Dilaver, Ragibe Gulsah, Vanderbilt University Medical Center, Department of Medicine, Nashville, Tennessee, United States

Ragibe Gulsah Dilaver, MD

• Demirci, Mert, Vanderbilt University Medical Center Department of Radiology, Nashville, Tennessee, United States

Mert Demirci, MD

• Crescenzi, Rachelle, Vanderbilt University Medical Center Department of Radiology, Nashville, Tennessee, United States

Rachelle Crescenzi, PhD

• Pridmore, Michael, Vanderbilt University Medical Center Department of Radiology, Nashville, Tennessee, United States

Michael Pridmore, MA, PhD

• Ikizler, Talat Alp, Vanderbilt University Medical Center, Department of Medicine, Nashville, Tennessee, United States

Talat Alp Ikizler, MD, FASN

• Gamboa, Jorge, Vanderbilt University Medical Center, Department of Medicine, Nashville, Tennessee, United States

Jorge Gamboa, MD, PhD

Background

Sarcopenia is common in patients undergoing maintenance hemodialysis (MHD) and is associated with poor physical function. Excessive accumulation of intramuscular adipose tissue (IMAT) is associated with poor physical function in patients with obesity, heart failure, and type 2 diabetes. We examined the extent of IMAT accumulation in MHD patients compared to individuals without kidney disease. We further investigated the factors that are associated with IMAT accumulation.

Methods

We cross-sectionally studied 49 participants (23 controls and 26 patients on MHD). IMAT accumulation in the leg muscle groups was measured using magnetic resonance imaging (MRI) by finding the widest part of the calf. Additional analyses were done for body composition, muscle function (hand grip strength), inflammatory biomarkers, and markers of mitochondrial function (mtDNA).

Results

The controls and patients were matched by age (52±13 versus 56±15 years), gender (%83 male versus %86), and BMI (31.9±4.9 vs 29.7±7.7 kg/m²). IMAT accumulation was significantly higher in the MHD group compared to the controls (IMAT 0.113 (0.065 – 0.143) for MHD vs 0.063 (0.047 – 0.073) for control; p = 0.0008; Figure 1A). IMAT accumulation was positively associated with BMI (p < 0.05, Rho = 0.284) (Figure 1B), IL-6 (p = 0.001, Rho = 0.437) (Figure 1C), and negatively associated with the hand grip test (p < 0.05, Rho = -0.361) (Figure 1D).

Conclusion

Patients on MHD display a greater accumulation of IMAT compared to matched controls. IMAT accumulation could be mediated by systemic inflammatory response and might be responsible for decreased muscle function and sarcopenia in patients on MHD.

Funding

• NIDDK Support