Abstract: SA-PO674
Association of Sleep-Disordered Breathing with Isolated Diastolic Hypertension in Youth Referred for Hypertension Disorders
Session Information
- Pediatric Nephrology - 2
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1900 Pediatric Nephrology
Authors
- Pudupakkam, Ashna, Baylor College of Medicine, Houston, Texas, United States
- Siddiqui, Sahar, Baylor College of Medicine, Houston, Texas, United States
- Campbell, Fallon, Baylor College of Medicine, Houston, Texas, United States
- South, Andrew M., Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
- Onugha, Elizabeth Anyaegbu, Baylor College of Medicine, Houston, Texas, United States
Background
Sleep-disordered breathing is associated with an increased risk of hypertension. Studies have shown that adults with sleep-disordered breathing have a higher prevalence of isolated diastolic hypertension. While youth with sleep-disordered breathing have higher daytime diastolic blood pressures, the association of sleep-disordered breathing with isolated diastolic hypertension in youth is unclear. We aimed to determine the association of sleep-disordered breathing with isolated diastolic hypertension in youth referred for hypertension disorders.
Methods
Cross-sectional analysis of baseline data from the Study of the Epidemiology of Pediatric Hypertension (SUPERHERO), a multisite Registry that retrospectively collects electronic health record data validated by manual record review. We included patients with ICD-10 codes for hypertension disorders at the index visit at subspecialty hypertension clinics who were aged <19 years. We excluded patients with ICD-10 code-identified pregnancy, kidney failure on dialysis, or kidney transplantation. Our exposures were an ICD-10 code visit diagnosis for sleep-disordered breathing at the index visit. Our outcomes included blood pressure severity at the index visit. We used unadjusted generalized linear models.
Results
In our cohort, 5% of participants (560 of 10,968) had an ICD-10 code for sleep disordered breathing. Participants with an ICD-10 code for sleep-disordered breathing had higher odds of having blood pressure at the isolated diastolic hypertension level at baseline.
Conclusion
In our large cohort of youth referred for hypertension disorders, we found that sleep disordered breathing was associated with isolated diastolic hypertension at baseline. This study may have been impacted by lack of longitudinal blood pressure data and variation in pharmacologic management of hypertension. In future studies, we plan to investigate the association of sleep-disordered breathing with target organ injury to determine the long-term impact of isolated diastolic hypertension in youth.