Kidney Week

Abstract: PUB526

Influence of Anemia Prior to Kidney Transplant in Early Graft Function

Session Information

• Publication Only

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Torres Cuevas, Jose Luis, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Jose Luis Torres Cuevas, MD

• Camacho Luna, Manuel, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Manuel Camacho Luna, MD

• Ulloa Galvan, Victor Manuel, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Victor Manuel Ulloa Galvan, MD

• Yama Estrella, Martin Benjamin, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Martin Benjamin Yama Estrella, MD

• Rosillo-Salgado, Ydris Zelim, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Ydris Zelim Rosillo-Salgado, MD

• Velasco Garcia Lascurain, Francisco, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Francisco Velasco Garcia Lascurain, MD

• Flores, Christian Perez, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Christian Perez Flores, MD

• Fernandez Vivar, Citlali, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Citlali Fernandez Vivar, MD

• Matias Carmona, Mayra May, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Mayra May Matias Carmona, DrMed

• Cano Cervantes, Jose H., Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico City, Mexico

Jose H. Cano Cervantes, PhD

Background

Modifiable factors associated to better allograft function are relevant to de success of the kidney transplant. Anemia, complication associated to chronic kidney disease could influence in allograft function.

Methods

Retrospective, cross-sectional study, included transplant kidney receptors of a single Mexican third level healthcare center performed in 2017-2019. Univariate logistic regression (odds ratios [OR], 95% CI) were used to evaluate allograft function associations, spearman correlation coefficient (SCC) was also performed to continuous variables.

Results

A total of 97 participants were included (52% from living kidney donors), the median age was 33 (25-48), 61 (62.9%) were women and 51 (52.6%) were living kidney donors, mean hemoglobin (Hb) pre-transplant was 11.53 ± 2.18, median transferrin saturation (TS) was 28.2 (17-35). Anemia (Hb < 11 g/dl) prevalence was 77.3% and iron deficiency (TS <20 %) in 34%. Inmediate graft function (IGF) defined as serum creatinine decrease of at least 70% of preoperative value in the first week was recorded in 75 participants (77.3%), delayed graft function (DGF), defined by requirement of dialytic therapy in the first week after kidney transplantation, was identified in 11 participants (11.3%). The OR for IGF by anemia and iron deficiency were OR= 0.74, 95% CI, (0.28- 1.93) and OR=0.87, 95% IC, (0.32- 2.36) respectively. SCC between hemoglobin previous transplant and the glomerular filtration rate after 3 months was 0.13, p: 0.19.

Conclusion

Anemia previous a kidney transplant doesn’t influence in the early kidney function. Kidney transplantation in living kidney donors shouldn’t be delayed by a specific hemoglobin target. Therapeutic interventions to increase hemoglobin previous kidney transplant in receptors of a cadaveric donor could be avoided.