Kidney Week

Abstract: TH-PO247

Evaluation of the Performance of the HA130 Hemoperfusion Cartridge in Patients Treated with Postdilution Hemodiafiltration (HDF): A Comparative Study with HDF Online Alone

Session Information

• Hemodialysis, Hemodiafiltration, and Frequent Dialysis
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Floris, Matteo, Azienda Ospedaliera Brotzu, Cagliari, Italy

Matteo Floris, MD

• Atzeni, Alice, Azienda Ospedaliera Brotzu, Cagliari, Italy

Alice Atzeni, MD

• Puddu, Claudia, Azienda Ospedaliera Brotzu, Cagliari, Italy

Claudia Puddu

• Spanu, Giulia, Azienda Ospedaliera Brotzu, Cagliari, Italy

Giulia Spanu

• Pani, Cristina, Azienda Ospedaliera Brotzu, Cagliari, Italy

Cristina Pani

• Trevisani, Francesco, IRCCS Ospedale San Raffaele, Milano, Italy

Francesco Trevisani, MD, PhD

• Angioi, Andrea, Azienda Ospedaliera Brotzu, Cagliari, Italy

Andrea Angioi, MD, FASN

• Lepori, Nicola, Azienda Ospedaliera Brotzu, Cagliari, Italy

Nicola Lepori, MD

• Cabiddu, Gianfranca, Azienda Ospedaliera Brotzu, Cagliari, Italy

Gianfranca Cabiddu, MD

• Pani, Antonello, Azienda Ospedaliera Brotzu, Cagliari, Italy

Antonello Pani, MD

Background

Adsorption is a new frontier in extracorporeal purification for continuous and intermittent RRT. Evidence mainly comes from its use with bicarbonate dialysis. As OL-HDF is the new standard, we explored its benefits in HDF. This pilot study assesses the efficacy, safety, and tolerability of the HA130 cartridge with HDF-POST, compared to HDF alone.

Methods

Ten ESRD patients with AVF were treated with hemoperfusion using the HA-130 cartridge in series with POST-HDF with a TCA membrane (Solacea™ 1.7 and 1.9), reaching a 23 L x 1.73 m² exchange volume. A control group of ten similar patients received POST-HDF with the Solacea filter alone. Removal rates (RR) for various markers were evaluated and corrected for hemoconcentration. Session tolerability was assessed by monitoring intradialytic symptoms and circuit coagulation.

Results

For the HA130 + Solacea group, the exchanged infusion volumes were 22.9 ± 1L. The treatment was generally well tolerated without significant intradialytic symptoms or circuit coagulation. For the Solacea alone group, the exchanged infusion volumes were 23 ± 1L. The treatment was also well tolerated without significant intradialytic symptoms or circuit coagulation. The RR data for both groups are reported in Table 2 and Figure 1.

Conclusion

The combined HDF-POST + hemoperfusion treatment demonstrated superior depurative efficacy with high RRs for medium and high molecular weight molecules compared to the Solacea filter alone. The high tolerability and absence of significant complications during HDF-POST sessions highlight the potential of this technological combination in high-efficiency RRT settings.