Abstract: FR-PO905
Profiles of IgA Deposition and Patterns in Kidney Diseases
Session Information
- IgA Nephropathy: Clinical, Outcomes, and Therapeutics
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Song, Jiarong, The Second Xiangya Hospital of Central South University Department of Nephrology, Changsha, Hunan, China
- Zhu, Xuejing, The Second Xiangya Hospital of Central South University Department of Nephrology, Changsha, Hunan, China
- Yuan, Shuguang, The Second Xiangya Hospital of Central South University Department of Nephrology, Changsha, Hunan, China
- Liu, Hong, The Second Xiangya Hospital of Central South University Department of Nephrology, Changsha, Hunan, China
- Li, Yifu, Institute of Nephrology,Central South University, Changsha, China
Background
IgA is the most abundant type of antibodies in human body. It involved in the susceptibility of mucosal pathogens in celiac disease, inflammatory bowel diseases and certain kidney diseases. Kidney biopsy with dominant or co-dominant mesangial IgA staining is required for diagnosis of IgA nephropathy (IgAN). However, there are IgA depositions or not in other kidney diseases or its pattern was not fully understood.
Methods
This retrospective study reviewed the renal biopsy records between August 2011 and November 2022 from a single medical center in Changsha, China. Relevant clinical and histological records were documented for standard diagnosis. Grouping the IgA deposit patterns as “Mesangial area only”, “Glomerular capillary loops only”and “co-staining” were based on immunofluorescence staining records, which summarized the IgA deposition and pattern profiles in kidney diseases.
Results
Totally 12,205 cases of renal biopsy were performed in the period. Finally 12,102 cases were enrolled for analysis after removal of the cases with incompleted data. 7,040 of 12,102 cases (58.17%) had IgA positive staining. Among them, 4,034 cases (57.30%) were diagnosed as IgAN. The most common IgA staining positive diseae is IgAN (100%), IgA vasculitis nephritis (95%), Lupus nephritis (75%), and HBV-associated nephropathy (60%), see detail in Table 1. The IgA deposition pattern differnece had been noted in major IgA associated disease (Table 2).
Conclusion
Mesangial IgA deposition is a histopathologic hallmark of IgAN, however, IgA deposits in kidney is also common in some IgA associated diseases such as IgAVN, LN and HBVAN. Whether deposition intensity and patterns of IgA is associated with hetergenous clinical phenotypes needs further investigation.
Table 2. IgA deposition patterns in major IgA associated kidney diseases
| Pattern | IgAN | IgAVN | LN | HBVAN |
| Mesangial area only | 3389(84.01%) | 346(77.93%) | 81（13.48%） | 182（53.37%） |
| Glomerular capillary loops only | 0 | 7(1.58%） | 220（36.61%） | 75（21.99%） |
| co-staining | 645(15.99%) | 91（20.50%） | 300（49.92%） | 84（24.63%） |