Kidney Week

Abstract: TH-PO479

Association of Tumor Necrosis Factor Receptor 1 (TNFR1) and TNFR2 with Kidney Volume and Function in Patients with ADPKD

Session Information

• Cystic Kidney Diseases: Clinical Assessment and Therapeutic Directions
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1201 Genetic Diseases of the Kidneys: Cystic

Authors

• Ozcan, Seyda Gul, Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi, Fatih, Istanbul, Turkey

Seyda Gul Ozcan, MD, DrMed

• Ergul, Metin, Kocaeli Universitesi, Kocaeli, Turkey

Metin Ergul, MD

• Ersoy, Durdane Yagmur, Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi, Fatih, Istanbul, Turkey

Durdane Yagmur Ersoy, MD

• Dincer, Mevlut Tamer, Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi, Fatih, Istanbul, Turkey

Mevlut Tamer Dincer, MD

• Bolayirli, Ibrahim Murat, Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi, Fatih, Istanbul, Turkey

Ibrahim Murat Bolayirli, DrMed

• Eren, Necmi, Kocaeli Universitesi, Kocaeli, Turkey

Necmi Eren, MD

• Seyahi, Nurhan, Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi, Fatih, Istanbul, Turkey

Nurhan Seyahi, MD, DrMed

Background

ADPKD is a genetic disorder with numerous kidney cysts,leading to increased kidney volume and compromised kidney function.TNF receptors (TNFR1,TNFR2) mediate the intracellular effects of TNF-α,an inflammatory cytokine that may influence cyst growth in ADPKD.We aimed to investigate the association between TNFR1/TNFR2 levels and kidney function and volume in ADPKD patients.

Methods

We recruited adult ADPKD patients(Mayo Class IC-E).Serum TNFR1/TNFR2 levels were measured using ELISA.Kidney volumes were assessed using MRI.Kidney function was evaluated using serum creatinine and cystatin C-based eGFR.Statistical analysis was performed to determine correlations between TNFR levels,kidney volumes,and function.

Results

We examined a total of 50 patients.Demographic,clinical,and laboratory data are shown in Table 1.No significant correlations were found between kidney volume and TNFR1/TNFR2 levels.There was a weak negative correlation between eGFR and TNFR1(r=-0.332,p=0.019).TNFR1 and TNFR2 levels were not significantly different between Mayo stages D-E and C.

Conclusion

TNFR1 may be associated with decreased kidney function in ADPKD.Longitudinal studies are needed to determine if a causal relationship exists between TNFR levels and kidney function.Further research is warranted to explore other potential biomarkers influencing kidney enlargement and functional decline in ADPKD patients.