Kidney Week

Abstract: SA-PO663

Impact of Proteinuric Glomerular Disease on Educational Outcomes in the Cure Glomerulonephropathy (CureGN) Study

Session Information

• Pediatric Nephrology - 2
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• 1900 Pediatric Nephrology

Authors

• Abdullah, Mahie M., Northwell Health, New Hyde Park, New York, United States

Mahie M. Abdullah

• Schuchman, Matthew, Northwell Health, New Hyde Park, New York, United States

Matthew Schuchman

• Castellanos, Laura J., Northwell Health, New Hyde Park, New York, United States

Laura J. Castellanos, MD

• Singer, Pamela, Northwell Health, New Hyde Park, New York, United States

Pamela Singer, MD, MS

• Basalely, Abby Miriam, Northwell Health, New Hyde Park, New York, United States

Abby Miriam Basalely, MD, MS

• Shen, Carol Liu, Northwell Health, New Hyde Park, New York, United States

Carol Liu Shen, MD

• Frank, Rachel, Northwell Health, New Hyde Park, New York, United States

Rachel Frank, CNN, RN

• Vento, Suzanne, Northwell Health, New Hyde Park, New York, United States

Suzanne Vento, RN

• Sethna, Christine B., Northwell Health, New Hyde Park, New York, United States

Christine B. Sethna, MD, MEd

Group or Team Name

• On behalf of CureGN.

Background

Children with chronic health disorders frequently experience difficulties within the educational system, which can result in poorer educational outcomes (EO). However, EO in proteinuric glomerular diseases remain understudied. The objective was to assess how glomerular disease diagnosis (GDD) and kidney function affect school enrollment, special education and educational attainment.

Methods

Longitudinal analysis included all visits from children aged 5-18 years enrolled in CureGN. Main exposures were GDD (minimal change disease [MCD], focal segmental glomerulosclerosis [FSGS], membranous nephropathy [MN], IgA nephropathy [IgA]) and glomerular filtration rate (eGFR, CKID U25). EOs were absenteeism (>15 days of missed school/year), school enrollment (part-time/home schooled/not enrolled), special education and grade repetition. Generalized estimating equations (GEE) examined the association of GDD and eGFR individually with EOs in models adjusted for age, sex, maternal education and duration of diagnosis.

Results

Of 901 children (12.65±3.56 years, 58.8% male, 28.23 months follow-up), the prevalence of absenteeism was 11.1%, part-time enrollment was 1.4%, not enrolled was 2.8%, special education was 12.5%, and grade repetition was 1.9%. In adjusted models, the diagnosis of IgA was associated with lower odds of absenteeism compared to MCD. eGFR was not associated with any EO. (Table)

Conclusion

In CureGN, GDD was associated with absenteeism, highlighting the importance of developing individualized approaches to decrease the risk of adverse EOs and promote academic success. Further research is needed to understand the underlying mechanisms of GDD that promote such disparities in this vulnerable population.

Funding

• NIDDK Support