Kidney Week

Abstract: PUB380

C3 Glomerulonephritis, Rare Association with Multiple Myeloma: A Case Report

Session Information

• Publication Only

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics

Authors

• Román López, Leonel Pedro, Hospital Juarez de Mexico, Mexico City, Mexico City, Mexico

Leonel Pedro Román López, DrMed, PA

• Soto, Virgilia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico

Virgilia Soto, MD

• Garcia-Flores, Octavio Rene, Hospital Juarez de Mexico, Mexico City, Mexico City, Mexico

Octavio Rene Garcia-Flores, MD

Introduction

In C3 glomerulonephritis, a monoclonal protein can cause kidney damage indirectly. Acting as an autoantibody, the protein cannot be detected in kidney biopsy, which promotes deregulation of the alternative pathway of the complement system.

Case Description

43-year-old male with a history of abused substances. Beginning current condition of bromuria for 8 years, with remission and exacerbation. The presence of bromuria increases, during realitation of laboratory evidence of deteriorating function kidney and proteinuria in subnephrotic rank, electrophoresis urine presence of predominant kapa chains and igg, as well as a bone marrow aspiration is carried out with a predominance of >20% plasma cells, diagnostic multiple myeloma, renal biopsy diagnosis of C3 nephropathy.

Discussion

There are few cases of C3 nephropathy associated with multiple myeloma. The pathophysiology remains unknown, however, in the presence of C3 nephropathy it is required to search intentionally for multiple myeloma. More studies are required to denote whether treatment directed at the neoplasia reduces kidney injury. In this case it was not a satisfactory answer.

Labs

Immunofluorescense, with presense deposit inmunocomplex with intersticion.

Immunofluorescence, not present a reaction for chain kappa.