Abstract: PUB379
A Decade of Biopsy-Proven Kidney Diseases: Temporal Trends and Clinical Correlates from a Single Tertiary Center in Saudi Arabia, 2013-2022
Session Information
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Al Dalbhi, Sultan, Prince Sultan Military Medical City, Riyadh, Riyadh, Saudi Arabia
- Alotaibi, Manal Eidhah Q., Umm Al-Qura University, Makkah, Saudi Arabia
Background
Kidney biopsy is the gold standard for diagnosing glomerular diseases. Large-scale epidemiologic studies describing the prevalence of kidney diseases are limited. This study aims to determine the spectrum of biopsy-proven kidney disease at a tertiary center; Prince Sultan Military Center in Saudi Arabia over ten years
Methods
This cross-sectional observational study analyzed data from 1027 patients who underwent kidney biopsies from 2013 to 2022. We included all patients with native kidney biopsies, excluding transplant and donor biopsies. The data included demographic and clinical characteristics stratified by year, age, sex, and diagnosis to determine epidemiologic trends. Temporal trends in biopsy diagnoses were analyzed using time-series methods to determine changes in diagnosis frequencies over the past decade. Associations between biopsy diagnoses and clinical characteristics (age, gender, BMI, co-morbidities, transplant status) were evaluated using multivariate logistic regression models. Outcomes and treatment responses for the most common biopsy diagnoses were assessed, focusing on diseases with significant prevalence changes over time.
Results
The study included 1027 patients. The median age was 55 years with a nearly equal distribution of male and female patients. The most common biopsy diagnoses were focal segmental glomerulonephritis (FSGS) 14.6% and diabetic nephropathy 13.6%, followed by IgA nephropathy 9.7% and lupus nephritis 8.8%. The COVID-19 pandemic led to a reduction in the number of biopsies performed, but the distribution of diagnoses remained relatively stable.
Conclusion
This study catalogs the spectrum of biopsy-proven kidney diseases over ten years. These findings highlight the need for a standardized national kidney biopsy registry to enhance glomerular disease research.