Abstract: TH-PO291
Cannabis Use in Patients on Maintenance Hemodialysis (HD) with Chronic Pain: A Secondary Analysis of the HOPE Trial
Session Information
- Hemodialysis and Frequent Dialysis - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Scherer, Jennifer S., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Wu, Wenbo, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Wetmore, James B., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Liebschutz, Jane, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Bhatraju, Elenore P., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Cavanaugh, Kerri L., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Morasco, Benjamin J., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Hsu, Jesse Yenchih, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Dember, Laura M., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Kimmel, Paul L., National Institutes of Health, Bethesda, Maryland, United States
- Kalim, Sahir, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Cheatle, Martin, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Holden, Christopher C., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Walsh, Joanna, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Wilkie, Caroline M., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Becker, William, HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
- Charytan, David M., HOPE Trial Consortium, Philadelphia, Pennsylvania, United States
Background
Legalization may increase cannabis use by maintenance hemodialysis (HD) patients. Data on frequency or factors associated with use by HD patients are limited.
Methods
The HOPE Consortium Trial to Reduce Pain and Opioid Use in HD is a multicenter randomized trial that enrolled patients with at least moderate chronic pain receiving HD at 103 US dialysis facilities from 01/2024 to 04/2023. Demographics, social and medical history, cannabis use, pain intensity and interference, depression, and anxiety, were collected at baseline. Multi-variable logistic regression was used to examine associations of cannabis use with baseline data.
Results
Among 643 participants, 102 (16%) reported current cannabis use, 133 (21%) former use, and 408 (63%) never used. Of current users, 39% resided in states with full cannabis legality, 40% in states that legalized use during the study, 15% in states with medical use legality, and 5% in states where medical use was legalized during enrollment. Compared to non-users/past users, current cannabis users were younger (54 vs. 63 years), more likely to be disabled (79% vs. 66%), to have received dialysis for >5 years (40% vs. 30%), to have a diagnosis of depression (41% vs. 31%), anxiety (28% vs. 20%), or any psychological disorder (51% vs. 38%), and less likely to be married (16% vs. 34%). In adjusted models, there was a lower likelihood of cannabis use in older individuals (OR=0.23 [95%CI 0.12-0.44], 0.25 [0.14-0.50], in age groups 55-65, and 65-75 respectively, compared to ages 18-55, p<0.01) and in married individuals (OR=0.49 [0.26-0.93], p =0.03).Use was more likely in current (OR=2.95 [1.51-5.76]) or former (OR=2.16 [1.20-3.91]) smokers, and alcohol users (OR=2.67 [1.32-5.41]). We did not find significant associations of cannibas use with pain or psychological measurements.
Conclusion
Cannabis use is common in HD patients with chronic pain. Younger, unmarried individuals, who use other substances may be the most likely to use cannabis.
Funding
- NIDDK Support