Kidney Week

Abstract: PUB574

Effects of Coronary Artery Bypass Grafting on Kidney Function and Associated Risk Factors in Patients with CKD: A 12-Month Prospective Study

Session Information

• Publication Only

Category: CKD (Non-Dialysis)

• 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Rahmanian, Mohammad, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)

Mohammad Rahmanian, MD, MPH

• Samavat, Shiva, Chronic Kidney Disease Research Center (CKDRC), Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran (the Islamic Republic of)

Shiva Samavat

• Ghotbein, Reza, Shahid Beheshti University of Medical Sciences School of Medicine, Tehran, Iran (the Islamic Republic of)

Reza Ghotbein, MD

• Borumandnia, Nasrin, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)

Nasrin Borumandnia

• Nooralishahi, Behrang, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)

Behrang Nooralishahi

Background

This study aims to investigate the impact of coronary artery bypass grafting (CABG) on the 12-month glomerular filtration rate (GFR) in Iranian patients with chronic kidney disease (CKD) and to identify the factors associated with changes in GFR.

Methods

One hundred patients undergoing CABG were enrolled in the study. GFRs were assessed at 3-, 6-, and 12-months post-surgery. Analyses were conducted to obtain the trend of GFR. Additionally, a linear regression analysis using the Generalized Estimating Equations (GEE) approach was conducted to explore the effect of various predictors on the trend of GFR. The B coefficient was reported for each parameter to measure the estimated change in GFR for each unit increase in the parameter, holding all other parameters constant.

Results

Prior to surgery, the mean GFR was 62.5. At 3-, 6-, and 12-months post-surgery, the mean GFRs were 58.1, 58.4, and 56.8, respectively, showing a decreasing trend (P value<0.05). Among various possible predictors, gender, age, pre-op hemoglobin, AKI during admission, intra-aortic balloon pump (IABP), and renal replacement therapy (RRT) showed a statistically significant effect on the trend of GFR (P < 0.05). However, no significant correlations were found between the GFR trend and factors such as body surface area (BSA), smoking, ejection fraction (EF), type of surgery, hypertension, diabetes, cerebrovascular accident (CVA), and anemia (P > 0.05).

Conclusion

The declining trend of GFR and its predictive factors, including gender, age, pre-operation hemoglobin, AKI during admission, IABP, and RRT, should be considered when CKD patients undergo CABG.
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The results of the linear regression analysis.